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AB270803

GNE7915, LRRK2 inhibitor

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MW 443.4 Da, Purity >99%. Potent and selective, brain penetrant LRRK2 inhibitor (IC50 = 9 nM; Ki = 1nM). Tested against a panel of 187 kinases only one was inhibited >50% at 100 nM. Displays moderate 5-HT2B anatagonist activity in vitro.
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Chemical Structure - GNE7915, LRRK2 inhibitor (AB270803)
  • Chemical Structure

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Chemical Structure - GNE7915, LRRK2 inhibitor (AB270803)

Chemical structure of GNE7915, LRRK2 inhibitor, 1351761-44-8

Key facts

CAS number

1351761-44-8

Purity

>99%

Form

Solid

form

Molecular weight

443.4 Da

Molecular formula

C<sub>1</sub><sub>9</sub>H<sub>2</sub><sub>1</sub>F<sub>4</sub>N<sub>5</sub>O<sub>3</sub>

PubChem

58539171

Nature

Synthetic

Solubility

Soluble in DMSO to 50 mM warming

Biochemical name

[4-[[4-(Ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-2-fluoro-5-methoxyphenyl]-morpholin-4-ylmethanone

Biological description

Potent and selective, brain penetrant LRRK2 inhibitor (IC50 = 9 nM; Ki = 1nM). Tested against a panel of 187 kinases only one was inhibited >50% at 100 nM. Displays moderate 5-HT2B anatagonist activity in vitro.

Canonical smiles

CCNC1=NC(=NC=C1C(F)(F)F)NC2=C(C=C(C(=C2)F)C(=O)N3CCOCC3)OC

InChi

InChI=1S/C19H21F4N5O3/c1-3-24-16-12(19(21,22)23)10-25-18(27-16)26-14-9-13(20)11(8-15(14)30-2)17(29)28-4-6-31-7-5-28/h8-10H,3-7H2,1-2H3,(H2,24,25,26,27)

InChiKey

XCFLWTZSJYBCPF-UHFFFAOYSA-N

IUPAC Name

[4-[[4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-2-fluoro-5-methoxyphenyl]-morpholin-4-ylmethanone

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Product promise

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For full details, please see our Terms & Conditions
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