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MW 443.4 Da, Purity >99%. Potent and selective, brain penetrant LRRK2 inhibitor (IC50 = 9 nM; Ki = 1nM). Tested against a panel of 187 kinases only one was inhibited >50% at 100 nM. Displays moderate 5-HT2B anatagonist activity in vitro.

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Images

Chemical Structure - GNE7915, LRRK2 inhibitor (AB270803), expandable thumbnail

Key facts

CAS number
1351761-44-8
Purity
> 99%
Form
Solid
Molecular weight
443.4 Da
Molecular formula
C19H21F4N5O3
PubChem identifier
58539171
Nature
Synthetic

Target data

Recommended products

MW 443.4 Da, Purity >99%. Potent and selective, brain penetrant LRRK2 inhibitor (IC50 = 9 nM; Ki = 1nM). Tested against a panel of 187 kinases only one was inhibited >50% at 100 nM. Displays moderate 5-HT2B anatagonist activity in vitro.

Key facts

Purity
> 99%
PubChem identifier
58539171
Solubility

Soluble in DMSO to 50 mM warming.

Biochemical name
[4-[[4-(Ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-2-fluoro-5-methoxyphenyl]-morpholin-4-ylmethanone
Biological description

Potent and selective, brain penetrant LRRK2 inhibitor (IC50 = 9 nM; Ki = 1nM). Tested against a panel of 187 kinases only one was inhibited >50% at 100 nM. Displays moderate 5-HT2B anatagonist activity in vitro.

Canonical SMILES
CCNC1=NC(=NC=C1C(F)(F)F)NC2=C(C=C(C(=C2)F)C(=O)N3CCOCC3)OC
InChI
InChI=1S/C19H21F4N5O3/c1-3-24-16-12(19(21,22)23)10-25-18(27-16)26-14-9-13(20)11(8-15(14)30-2)17(29)28-4-6-31-7-5-28/h8-10H,3-7H2,1-2H3,(H2,24,25,26,27)
InChIKey
XCFLWTZSJYBCPF-UHFFFAOYSA-N
IUPAC name
[4-[[4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-2-fluoro-5-methoxyphenyl]-morpholin-4-ylmethanone

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C

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1 product image

  • Chemical Structure - GNE7915, LRRK2 inhibitor (ab270803), expandable thumbnail

    Chemical Structure - GNE7915, LRRK2 inhibitor (ab270803)

    Chemical structure of GNE7915, LRRK2 inhibitor, 1351761-44-8

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Product protocols

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