MW 378.4 Da, Purity >99%. Potent, selective PKC inhibitor (IC50 values are 2.3 and 6.2 nM at PKCα and β1, respectively). Selectively inhibits Ca2+-dependent PKC isoforms over Ca2+-independent. No inhibitory activity at PKCδ, ε or ζ. Antitumor agent. Active in vitro and in vivo.
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- Journal of neurochemistry 161:478-4912022Signaling pathways involved in NMDA-induced suppression of M-channels in corticotropin-releasing hormone neurons in central amygdala.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHua Zhang,Zhao-Fu Sheng,Jingxiong Wang,PeiRu Zheng,XunLei Kang,Hui-Ming Chang,Edward T H Yeh,De-Pei LiPubMed 35583089
- American journal of physiology. Cell physiology 321:C355-C3682021A rapid degradation of calponin 2 is required for cytokinesis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAirong Qian,Tzu-Bou Hsieh,M Moazzem Hossain,Jim J-C Lin,J-P JinPubMed 34133238
- Journal of neuroinflammation 16:362019Therapeutic hypercapnia reduces blood-brain barrier damage possibly via protein kinase Cε in rats with lateral fluid percussion injury.Applications:Unspecified applicationReactive species:Unspecified reactive speciesWan-Chao Yang et. al.PubMed 30760300
- The Journal of biological chemistry 294:887-9012018Inhibition of ezrin causes PKCα-mediated internalization of erbb2/HER2 tyrosine kinase in breast cancer cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJaekwang Jeong,Jungmin Choi,Wonnam Kim,Pamela Dann,Farzin Takyar,Julia V Gefter,Peter A Friedman,John J WysolmerskiPubMed 30463939
- The Journal of biological chemistry 293:11119-111302018Protein kinase Cα drives fibroblast activation and kidney fibrosis by stimulating autophagic flux.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXian Xue et. al.PubMed 29794026
- The Journal of pathology 242:488-4992017Rictor/mammalian target of rapamycin complex 2 promotes macrophage activation and kidney fibrosis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJiafa Ren et. al.PubMed 28585302
- Journal of leukocyte biology 101:683-6922017CXCL12-induced macropinocytosis modulates two distinct pathways to activate mTORC1 in macrophages.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRegina Pacitto,Isabella Gaeta,Joel A Swanson,Sei YoshidaPubMed 28250113
- Pain 157:1541-15502016Epac-protein kinase C alpha signaling in purinergic P2X3R-mediated hyperalgesia after inflammation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYanping Gu,Guangwen Li,Yong Chen,Li-Yen Mae HuangPubMed 26963850
Key facts
- CAS number
- 136194-77-9
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 378.4 Da
- Molecular formula
- C24H18N4O
- PubChem identifier
- 3501
- Nature
- Synthetic
Target data
Alternative names
AAG6, Aging associated gene 6, Beta-interferon, CVID9, D14Ertd420e, FLJ35621, FLJ37491, Fibroblast interferon, IFB, IFF, IFN-beta, IFNB 1, IFNB_HUMAN, Interferon beta, Interferon beta 1 fibroblast, Interferon beta precursor, KPCA_HUMAN, KPCB_HUMAN, KPCD1_HUMAN, KPCD_HUMAN, KPCE_HUMAN, KPCG_HUMAN, KPCL_HUMAN, Kinase PKC delta, May-01, MGC 5363, MGC125656, MGC125657, MGC26269, MGC49908, MGC57564, MGC96956, NAD-dependent deacetylase sirtuin-2, NAD-dependent protein deacetylase sirtuin-2, OTTHUMP00000067291, PCKd, PKC, PKC 2, PKC MU, PKC ZETA, PKC d, PKC delta, PKC epsilon, PKC h, PKC-A, PKC-B, PKC-L, PKC-alpha, PKC-beta, PKC-gamma, PKCC, PKCE, PKCG, PKCM, PKD, PLK4_HUMAN, PRKACA, PRKC D, PRKC delta, PRKCA, PRKCB, PRKCB I, PRKCB II, PRKCB1, PRKCB2, PRKCE, PRKCG, PRKCL, PRKCM, PRKCZ, PRKD 1, Pkcea, Polo-like kinase 4, Prkch, Protein Kinase C alpha, Protein Kinase C delta, Protein kinase C, Protein kinase C alpha type, Protein kinase C beta, Protein kinase C beta type, Protein kinase C delta VIII, Protein kinase C delta type, Protein kinase C epsilon, Protein kinase C epsilon type, Protein kinase C eta, Protein kinase C eta type, Protein kinase C gamma, Protein kinase C gamma polypeptide, Protein kinase C gamma type, Protein kinase C mu, Protein kinase C mu type, Protein kinase C zeta, Protein kinase D, Protein kinase D1, Protein-serine/threonine kinase, Regulatory protein SIR2 homolog 2, SAK, SCA 14, SIR2, S. cerevisiae, homolog-loke 2, SIR2-like protein 2, SIR2L, SIR2L2, SIRT 2, SIRT2_HUMAN, STK 18, Serine/Threonine Kinase 18, Serine/threonine kinase, Serine/threonine-protein kinase 18, Serine/threonine-protein kinase D1, Serine/threonine-protein kinase PLK4, Serine/threonine-protein kinase SAK, Silencing information regulator 2 like, Silent information regulator 2, Sir2 related protein type 2, Sirtuin (silent mating type information regulation 2 homolog) 2 (S.cerevisiae), Sirtuin 2, Sirtuin type 2, Snk Akin Kinase, Tyrosine protein kinase PRKCD, aPKC, nPKC-D1, nPKC-delta, nPKC-epsilon, nPKC-eta, nPKC-mu, protein kinase C, beta 1 polypeptide, protein kinase C, beta-1
Recommended products
MW 378.4 Da, Purity >99%. Potent, selective PKC inhibitor (IC50 values are 2.3 and 6.2 nM at PKCα and β1, respectively). Selectively inhibits Ca2+-dependent PKC isoforms over Ca2+-independent. No inhibitory activity at PKCδ, ε or ζ. Antitumor agent. Active in vitro and in vivo.
Key facts
- CAS number
- 136194-77-9
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 378.4 Da
- Molecular formula
- C24H18N4O
- PubChem identifier
- 3501
- Nature
- Synthetic
- Biochemical name
- Go-6976
- Biological description
Potent, selective PKC inhibitor (IC50 values are 2.3 and 6.2 nM at PKCα and β1, respectively). Selectively inhibits Ca2+-dependent PKC isoforms over Ca2+-independent. No inhibitory activity at PKCδ, ε or ζ. Antitumor agent. Active in vitro and in vivo.
- Canonical SMILES
- CN1C2=CC=CC=C2C3=C4C(=C5C6=CC=CC=C6N(C5=C31)CCC#N)CNC4=O
- InChI
- InChI=1S/C24H18N4O/c1-27-17-9-4-2-7-14(17)20-21-16(13-26-24(21)29)19-15-8-3-5-10-18(15)28(12-6-11-25)23(19)22(20)27/h2-5,7-10H,6,12-13H2,1H3,(H,26,29)
- InChIKey
- VWVYILCFSYNJHF-UHFFFAOYSA-N
- IUPAC name
- 3-(23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4,6,8,10,15,17,19,21-nonaen-3-yl)propanenitrile
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
Notes
This product is manufactured by BioVision, an Abcam company and was previously called 1711 Gö 6976. 1711-500 is the same size as the 500 µg size of ab141413.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Protein kinase C (PKC) is a family of enzymes playing important roles in cell signal transduction. This family includes PKC alpha PKC delta PKC mu/PKD PKC epsilon PKC beta 1 PKC beta 2 PKC gamma PKC eta and PLK4. PKC enzymes are serine/threonine kinases with a molecular mass ranging from approximately 77 to 94 kDa. They are expressed in various tissues like brain heart and lymphocytes. These kinases respond to increased diacylglycerol (DAG) and calcium levels to become active phosphorylating multiple target proteins to modulate cellular functions.
- Biological function summary
Members of the PKC family mediate many cellular processes including cell growth differentiation and apoptosis. PKC alpha delta and epsilon for example are important in signal transduction pathways involved in immune response. These kinases can function independently or as part of larger protein complexes. PKC inhibitors help study the precise biological roles of these kinases by blocking their activity in cells.
- Pathways
PKC family members participate in signaling pathways like the MAPK/ERK pathway and the PI3K/Akt pathway. These pathways are important for regulating cell proliferation and survival. PKC interacts with proteins such as Ras and Raf within these signaling cascades influencing the downstream signaling that affects cellular outcomes. The balance of PKC activity impacts not only normal cellular processes but also pathological conditions.
- Associated diseases and disorders
PKC family members are linked to conditions such as cancer and cardiovascular diseases. Abnormal PKC activity can lead to uncontrolled cell proliferation in cancers or altered cardiac functions in heart disease. Specifically PKC alpha and beta are associated with tumor progression whereas PKC epsilon has connections to cardiac hypertrophy. Understanding PKC's role in these diseases has led to the development of PKC inhibitors as potential therapeutic agents targeting these kinases to alter disease progression and outcomes.
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Chemical Structure - Go 6976, PKC inhibitor (ab141413)
2D chemical structure image of ab141413, Go 6976, PKC inhibitor
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