Go 6976, PKC inhibitor

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(10 Publications)

MW 378.4 Da, Purity >99%. Potent, selective PKC inhibitor (IC₅₀ values are 2.3 and 6.2 nM at PKCα and β1, respectively). Selectively inhibits Ca²⁺-dependent PKC isoforms over Ca²⁺-independent. No inhibitory activity at PKCδ, ε or ζ. Antitumor agent. Active in vitro and in vivo.

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AAG6, Aging associated gene 6, Beta-interferon, CVID9, D14Ertd420e, FLJ35621, FLJ37491, Fibroblast interferon, IFB, IFF, IFN-beta, IFNB 1, IFNB_HUMAN, Interferon beta, Interferon beta 1 fibroblast, Interferon beta precursor, KPCA_HUMAN, KPCB_HUMAN, KPCD1_HUMAN, KPCD_HUMAN, KPCE_HUMAN, KPCG_HUMAN, KPCL_HUMAN, Kinase PKC delta, May-01, MGC 5363, MGC125656, MGC125657, MGC26269, MGC49908, MGC57564, MGC96956, NAD-dependent deacetylase sirtuin-2, NAD-dependent protein deacetylase sirtuin-2, OTTHUMP00000067291, PCKd, PKC, PKC 2, PKC MU, PKC ZETA, PKC d, PKC delta, PKC epsilon, PKC h, PKC-A, PKC-B, PKC-L, PKC-alpha, PKC-beta, PKC-gamma, PKCC, PKCE, PKCG, PKCM, PKD, PLK4_HUMAN, PRKACA, PRKC D, PRKC delta, PRKCA, PRKCB, PRKCB I, PRKCB II, PRKCB1, PRKCB2, PRKCE, PRKCG, PRKCL, PRKCM, PRKCZ, PRKD 1, Pkcea, Polo-like kinase 4, Prkch, Protein Kinase C alpha, Protein Kinase C delta, Protein kinase C, Protein kinase C alpha type, Protein kinase C beta, Protein kinase C beta type, Protein kinase C delta VIII, Protein kinase C delta type, Protein kinase C epsilon, Protein kinase C epsilon type, Protein kinase C eta, Protein kinase C eta type, Protein kinase C gamma, Protein kinase C gamma polypeptide, Protein kinase C gamma type, Protein kinase C mu, Protein kinase C mu type, Protein kinase C zeta, Protein kinase D, Protein kinase D1, Protein-serine/threonine kinase, Regulatory protein SIR2 homolog 2, SAK, SCA 14, SIR2, S. cerevisiae, homolog-loke 2, SIR2-like protein 2, SIR2L, SIR2L2, SIRT 2, SIRT2_HUMAN, STK 18, Serine/Threonine Kinase 18, Serine/threonine kinase, Serine/threonine-protein kinase 18, Serine/threonine-protein kinase D1, Serine/threonine-protein kinase PLK4, Serine/threonine-protein kinase SAK, Silencing information regulator 2 like, Silent information regulator 2, Sir2 related protein type 2, Sirtuin (silent mating type information regulation 2 homolog) 2 (S.cerevisiae), Sirtuin 2, Sirtuin type 2, Snk Akin Kinase, Tyrosine protein kinase PRKCD, aPKC, nPKC-D1, nPKC-delta, nPKC-epsilon, nPKC-eta, nPKC-mu, protein kinase C, beta 1 polypeptide, protein kinase C, beta-1