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AB144414

Gouml 6983, PKC inhibitor

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(10 Publications)

MW 442.5 Da, Purity >98%. Potent, broad spectrum PKC inhibitor (IC50 values are 7, 7, 6, 10, 60 and 20000 nM for PKCα, PKCβ, PKCγ, PKCδ, PKCζ and PKCμ respectively). Shows cardioprotective and anti-ischemic effects in vivo. .

View Alternative Names

14-3-3-zetaisoform, AAG6, AI098070, Aging associated gene 6, Beta-interferon, C80388, CVID9, D14Ertd420e, EC 2.7.11.13, Fibroblast interferon, IFB, IFF, IFN, fibroblast, IFN-beta, IFNB 1, Interferon beta, KPCA_HUMAN, KPCB_HUMAN, KPCD_HUMAN, KPCG_HUMAN, KPCZ_HUMAN, Kinase PKC delta, May-01, MGC49908, MGC57564, MGC96956, OTTHUMP00000001368, OTTHUMP00000021131, OTTHUMP00000044160, OTTHUMP00000067291, PCKd, PKC 2, PKC ZETA, PKC d, PKC delta, PKC-A, PKC-B, PKC-alpha, PKC-beta, PKC-gamma, PKCC, PKCG, PKM-zeta, included, PRKACA, PRKC D, PRKC delta, PRKCA, PRKCB, PRKCB I, PRKCB II, PRKCB1, PRKCB2, PRKCG, PRKCZ, Pkcz, Protein Kinase C alpha, Protein Kinase C delta, Protein kinase C alpha type, Protein kinase C beta, Protein kinase C beta type, Protein kinase C delta VIII, Protein kinase C delta type, Protein kinase C gamma, Protein kinase C gamma polypeptide, Protein kinase C gamma type, Protein kinase C zeta, Protein kinase C zeta form, Protein kinase C zeta type, R74924, RP23-19G2.2, SCA 14, Tyrosine protein kinase PRKCD, aPKC, aPKCzeta, interferon beta 1, fibroblast, nPKC-delta, nPKC-zeta, protein kinase C, beta 1 polypeptide, protein kinase C, beta-1, r14-3-3, zetaPKC

Key facts

CAS number

133053-19-7

Purity

>98%

Form

Solid

form

Molecular weight

442.5 Da

Molecular formula

C<sub>2</sub><sub>6</sub>H<sub>2</sub><sub>6</sub>N<sub>4</sub>O<sub>3</sub>

PubChem

3499

Nature

Synthetic

Biochemical name

3-[1-[3-(Dimethylamino)propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione

Biological description

Potent, broad spectrum PKC inhibitor (IC50 values are 7, 7, 6, 10, 60 and 20000 nM for PKCα, PKCβ, PKCγ, PKCδ, PKCζ and PKCμ respectively). Shows cardioprotective and anti-ischemic effects in vivo.

Canonical smiles

CN(C)CCCN1C=C(C2=C1C=CC(=C2)OC)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54

InChi

InChI=1S/C26H26N4O3/c1-29(2)11-6-12-30-15-20(18-13-16(33-3)9-10-22(18)30)24-23(25(31)28-26(24)32)19-14-27-21-8-5-4-7-17(19)21/h4-5,7-10,13-15,27H,6,11-12H2,1-3H3,(H,28,31,32)

InChiKey

LLJJDLHGZUOMQP-UHFFFAOYSA-N

IUPAC Name

3-[1-[3-(dimethylamino)propyl]-5-methoxyindol-3-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dione

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months

Product protocols

Publications (10)

Recent publications for all applications. Explore the full list and refine your search

Nature protocols 19:1149-1182 PubMed38302732

2024

Human primordial germ cell-like cells specified from resetting precursors develop in human hindgut organoids.

Applications

Unspecified application

Species

Unspecified reactive species

João Pedro Alves-Lopes,Frederick C K Wong,M Azim Surani

The Journal of clinical investigation 133: PubMed37651195

2023

Endothelial VEGFR2-PLCγ signaling regulates vascular permeability and antitumor immunity through eNOS/Src.

Applications

Unspecified application

Species

Unspecified reactive species

Elin Sjöberg,Marit Melssen,Mark Richards,Yindi Ding,Catarina Chanoca,Dongying Chen,Emmanuel Nwadozi,Sagnik Pal,Dominic T Love,Takeshi Ninchoji,Masabumi Shibuya,Michael Simons,Anna Dimberg,Lena Claesson-Welsh

eLife 10: PubMed34939930

2021

Addition of a carboxy-terminal tail to the normally tailless gonadotropin-releasing hormone receptor impairs fertility in female mice.

Applications

Unspecified application

Species

Unspecified reactive species

Chirine Toufaily,Jérôme Fortin,Carlos Ai Alonso,Evelyne Lapointe,Xiang Zhou,Yorgui Santiago-Andres,Yeu-Farn Lin,Yiming Cui,Ying Wang,Dominic Devost,Ferdinand Roelfsema,Frederik Steyn,Aylin C Hanyaloglu,Terence E Hébert,Tatiana Fiordelisio,Derek Boerboom,Daniel J Bernard

Nature communications 11:6425 PubMed33349630

2020

Enriched conditioning expands the regenerative ability of sensory neurons after spinal cord injury via neuronal intrinsic redox signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Francesco De Virgiliis,Thomas H Hutson,Ilaria Palmisano,Sarah Amachree,Jian Miao,Luming Zhou,Rositsa Todorova,Richard Thompson,Matt C Danzi,Vance P Lemmon,John L Bixby,Ilka Wittig,Ajay M Shah,Simone Di Giovanni

Autophagy :1-17 PubMed32762399

2020

A chemical genomics-aggrephagy integrated method studying functional analysis of autophagy inducers.

Applications

Unspecified application

Species

Unspecified reactive species

Tetsushi Kataura,Etsu Tashiro,Shota Nishikawa,Kensuke Shibahara,Yoshihito Muraoka,Masahiro Miura,Shun Sakai,Naohiro Katoh,Misato Totsuka,Masafumi Onodera,Kazuo Shin-Ya,Kengo Miyamoto,Yukiko Sasazawa,Nobutaka Hattori,Shinji Saiki,Masaya Imoto

Journal of inflammation (London, England) 17:18 PubMed32377171

2020

Inhibition of carrageenan-induced dental inflammatory responses owing to decreased TRPV1 activity by Dexmedetomidine.

Applications

Unspecified application

Species

Unspecified reactive species

Gang Lv,Guanhua Zhu,Maohua Xu,Xingping Gao,Qingfeng Xiao

eLife 9: PubMed32352382

2020

SKAP2 is required for defense against infection and neutrophil respiratory burst.

Applications

Unspecified application

Species

Unspecified reactive species

Giang T Nguyen,Lamyaa Shaban,Matthias Mack,Kenneth D Swanson,Stephen C Bunnell,David B Sykes,Joan Mecsas

eLife 9: PubMed32234213

2020

Calcium-stimulated disassembly of focal adhesions mediated by an ORP3/IQSec1 complex.

Applications

Unspecified application

Species

Unspecified reactive species

Ryan S D'Souza,Jun Y Lim,Alper Turgut,Kelly Servage,Junmei Zhang,Kim Orth,Nisha G Sosale,Matthew J Lazzara,Jeremy Allegood,James E Casanova

eLife 8: PubMed31210638

2019

A FRET sensor of C-terminal movement reveals VRAC activation by plasma membrane DAG signaling rather than ionic strength.

Applications

Unspecified application

Species

Unspecified reactive species

Benjamin König,Yuchen Hao,Sophia Schwartz,Andrew Jr Plested,Tobias Stauber

Cell stem cell 23:276-288.e8 PubMed30033119

2018

Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Tahsin Stefan Barakat,Florian Halbritter,Man Zhang,André F Rendeiro,Elena Perenthaler,Christoph Bock,Ian Chambers
View all publications

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