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MW 546 Da, Purity >95%. Non-hydrolyzable GTP analog. Has an amine group in place of an oxygen atom. Potent adenylate cyclase stimulator. Binds tightly to G-protein in the presence of Mg2+. Forms stable Ras complexes.

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Images

Chemical Structure - GppNHp, Non-hydrolyzable GTP analog (AB146659), expandable thumbnail

Publications

Key facts

CAS number

64564-03-0

Purity

> 95%

Form

Solid

Molecular weight

546 Da

Molecular formula

C10H13Li4N6O13P3

PubChem identifier

136494784

Nature

Synthetic

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MW 546 Da, Purity >95%. Non-hydrolyzable GTP analog. Has an amine group in place of an oxygen atom. Potent adenylate cyclase stimulator. Binds tightly to G-protein in the presence of Mg2+. Forms stable Ras complexes.

Key facts

Purity

> 95%

PubChem identifier

136494784

Solubility

Soluble in water to 75 mM.

Biochemical name

[[[[(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]amino]phosphonic acid

Biological description

Non-hydrolyzable GTP analog. Has an amine group in place of an oxygen atom. Potent adenylate cyclase stimulator. Binds tightly to G-protein in the presence of Mg2+. Forms stable Ras complexes.

Canonical SMILES

[Li+].[Li+].[Li+].[Li+].C1=NC2=C(N1C3C(C(C(O3)COP(=O)([O-])OP(=O)(NP(=O)([O-])[O-])[O-])O)O)N=C(NC2=O)N

Isomeric SMILES

[Li+].[Li+].[Li+].[Li+].C1=NC2=C(N1[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)([O-])OP(=O)(NP(=O)([O-])[O-])[O-])O)O)N=C(NC2=O)N

InChI

InChI=1S/C10H17N6O13P3.4Li/c11-10-13-7-4(8(19)14-10)12-2-16(7)9-6(18)5(17)3(28-9)1-27-32(25,26)29-31(23,24)15-30(20,21)22;;;;/h2-3,5-6,9,17-18H,1H2,(H,25,26)(H3,11,13,14,19)(H4,15,20,21,22,23,24);;;;/q;4*+1/p-4/t3-,5-,6-,9-;;;;/m1..../s1

InChIKey

NUKFMILQQVRELO-ZVQJTLEUSA-J

IUPAC name

tetralithium;[[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl]oxy-(phosphonatoamino)phosphinate

Storage

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate short-term storage conditions

-20°C

Appropriate long-term storage conditions

-20°C

Storage information

Store under desiccating conditions, The product can be stored for up to 12 months

Product promise

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1 product image

  • Chemical Structure - GppNHp, Non-hydrolyzable GTP analog (ab146659), expandable thumbnail

    Chemical Structure - GppNHp, Non-hydrolyzable GTP analog (ab146659)

    2D chemical structure image of ab146659, GppNHp, Non-hydrolyzable GTP analog

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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