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AB120523

GR 127935 hydrochloride, 5-HT1B/1D receptor antagonist

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(2 Publications)

MW 534.06 g/mol, Purity >97%. Potent and selective 5-HT1B/1D receptor antagonist (pKi = 8.5 for both 5-HT1D in rat and 5-HT1D in guinea pig). 100-fold selectivity over 5-HT1A, 5-HT1E, and 5-HT2C. Displays centrally mediated effects upon systemic administration.
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Chemical Structure - GR 127935 hydrochloride, 5-HT1B/1D receptor antagonist (AB120523)
  • Chemical Structure

Lab

Chemical Structure - GR 127935 hydrochloride, 5-HT1B/1D receptor antagonist (AB120523)

2D chemical structure image of ab120523, GR 127935 hydrochloride, 5-HT1B/1D receptor antagonist

Key facts

CAS number

148642-42-6

Purity

>97%

Form

Solid

form

Molecular weight

534.06 g/mol

Nature

Synthetic

Solubility

Soluble in water to 25 mM

Biological description

Potent and selective 5-HT1B/1D receptor antagonist (pKi = 8.5 for both 5-HT1D in rat and 5-HT1D in guinea pig). 100-fold selectivity over 5-HT1A, 5-HT1E, and 5-HT2C. Displays centrally mediated effects upon systemic administration.

IUPAC Name

N-[4-Methoxy-3-(4-methyl-1-piperazinyl)phenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-1,1'-biphenyl-4-carboxamide hydrochloride

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Complementary Products

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Biochemicals

AB120073

(+)-Tubocurarine chloride hydrochloride pentahydrate, ACh receptor antagonist

Chemical Structure - (+)-Tubocurarine chloride hydrochloride pentahydrate, ACh receptor antagonist (AB120073)

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Primary Antibodies

AB52945

Anti-Apolipoprotein A I antibody [EP1368Y]

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-Apolipoprotein A I antibody [EP1368Y] (AB52945)

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Primary Antibodies

AB272718

Anti-PPAR gamma antibody [EPR23297-111]

RabMAb|Recombinant

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Cell reports 39:110795 PubMed35545050

2022

Serotonin receptors contribute to dopamine depression of lateral inhibition in the nucleus accumbens.

Applications

Unspecified application

Species

Unspecified reactive species

Dennis A Burke,Veronica A Alvarez

Scientific reports 7:13609 PubMed29051549

2017

Chronic antidepressant potentiates spontaneous activity of dorsal raphe serotonergic neurons by decreasing GABA receptor-mediated inhibition of L-type calcium channels.

Applications

Unspecified application

Species

Unspecified reactive species

Nozomi Asaoka,Naoya Nishitani,Haruko Kinoshita,Hiroyuki Kawai,Norihiro Shibui,Kazuki Nagayasu,Hisashi Shirakawa,Takayuki Nakagawa,Shuji Kaneko
View all publications
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