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AB141428

GSK 0660, PPARdelta antagonist

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MW 418.5 Da, Purity >99%. Selective PPARδ antagonist (IC50 values are 0.155, > 10 and ≥ 10 μM at PPARδ, PPARα and PPARγ, respectively). Active in vivo. Exhibits inverse agonist effects when administered alone.
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Chemical Structure - GSK 0660, PPARdelta antagonist (AB141428)
  • Chemical Structure

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Chemical Structure - GSK 0660, PPARdelta antagonist (AB141428)

2D chemical structure image of ab141428, GSK 0660, PPARdelta antagonist

Key facts

CAS number

1014691-61-2

Purity

>99%

Form

Solid

form

Molecular weight

418.5 Da

Molecular formula

C<sub>1</sub><sub>9</sub>H<sub>1</sub><sub>8</sub>N<sub>2</sub>O<sub>5</sub>S<sub>2</sub>

PubChem

46233311

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biochemical name

Methyl 3-[(4-anilino-2-methoxyphenyl)sulfamoyl]thiophene-2-carboxylate

Biological description

Selective PPARδ antagonist (IC50 values are 0.155, > 10 and ≥ 10 μM at PPARδ, PPARα and PPARγ, respectively). Active in vivo. Exhibits inverse agonist effects when administered alone.

Canonical smiles

COC1=C(C=CC(=C1)NC2=CC=CC=C2)NS(=O)(=O)C3=C(SC=C3)C(=O)OC

InChi

InChI=1S/C19H18N2O5S2/c1-25-16-12-14(20-13-6-4-3-5-7-13)8-9-15(16)21-28(23,24)17-10-11-27-18(17)19(22)26-2/h3-12,20-21H,1-2H3

InChiKey

NDFKBGWLUHKMFY-UHFFFAOYSA-N

IUPAC Name

methyl 3-[(4-anilino-2-methoxyphenyl)sulfamoyl]thiophene-2-carboxylate

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Complementary Products

Primary Antibodies

AB72230

Anti-PGC1 alpha + beta antibody

Western blot - Anti-PGC1 alpha + beta antibody (AB72230)

  • 4
  • 2
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB37484

Anti-Myosin heavy chain antibody [A4.1025]

BOND RX™ Validated|Recombinant|Lab Essentials

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Myosin heavy chain antibody [A4.1025] (AB37484)

  • 0
  • 0
Primary Antibodies

AB108319

Anti-BDNF antibody [EPR1292]

BOND RX™ Validated|RabMAb|Recombinant

Western blot - Anti-BDNF antibody [EPR1292] (AB108319)

  • 4
  • 8
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
The product can be stored for up to 12 months
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Product protocols

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Product promise

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