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AB144575

GSK-3787, PPARdelta antagonist

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(1 Publication)

MW 392.8 Da, Purity >98%. Potent, selective, irreversible peroxisome proliferator-activated receptor delta (PPARδ) antagonist (IC50 = 130 nM). No affinity for PPARα or PPARγ. Orally active. Active in vivo and in vitro.

View Alternative Names

FAAR, MGC3931, NR1C2, NUC1, NUCI, NUCII, Nuclear hormone receptor 1, Nuclear receptor subfamily 1 group C member 2, PPAR-beta, PPAR-delta, PPAR-鑴, PPARB, PPARD_HUMAN, Peroxisome proliferative activated receptor delta, Peroxisome proliferator-activated receptor beta, Peroxisome proliferator-activated receptor beta (PPAR-beta), Peroxisome proliferator-activated receptor delta

1 Images
Chemical Structure - GSK-3787, PPARdelta antagonist (AB144575)
  • Chemical Structure

Lab

Chemical Structure - GSK-3787, PPARdelta antagonist (AB144575)

2D chemical structure image of ab144575, GSK-3787, PPARdelta antagonist

Key facts

CAS number

188591-46-0

Purity

>98%

Form

Solid

form

Molecular weight

392.8 Da

Molecular formula

C<sub>1</sub><sub>5</sub>H<sub>1</sub><sub>2</sub>ClF<sub>3</sub>N<sub>2</sub>O<sub>3</sub>S

PubChem

2800647

Nature

Synthetic

Solubility

Soluble in DMSO to 75 mM

Biochemical name

4-chloro-N-[2-[5-(trifluoromethyl)pyridin-2-yl]sulfonylethyl]benzamide

Biological description

Potent, selective, irreversible peroxisome proliferator-activated receptor delta (PPARδ) antagonist (IC50 = 130 nM). No affinity for PPARα or PPARγ. Orally active. Active in vivo and in vitro.

Canonical smiles

C1=CC(=CC=C1C(=O)NCCS(=O)(=O)C2=NC=C(C=C2)C(F)(F)F)Cl

InChi

InChI=1S/C15H12ClF3N2O3S/c16-12-4-1-10(2-5-12)14(22)20-7-8-25(23,24)13-6-3-11(9-21-13)15(17,18)19/h1-6,9H,7-8H2,(H,20,22)

InChiKey

JFUIMTGOQCQTPF-UHFFFAOYSA-N

IUPAC Name

4-chloro-N-[2-[5-(trifluoromethyl)pyridin-2-yl]sulfonylethyl]benzamide

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Complementary Products

Biochemicals

AB120876

T0070907, PPAR gamma antagonist

Chemical Structure - T0070907, PPAR gamma antagonist (AB120876)

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Biochemicals

AB141126

L-165,041, PPARdelta agonist

Chemical Structure - L-165,041, PPARdelta agonist (AB141126)

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Assay Kits

AB215402

Human IL-8 Matched Antibody Pair Kit

Recombinant

ELISA - Human IL-8 Matched Antibody Pair Kit (AB215402)

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Assay Kits

AB263885

Mouse Calprotectin ELISA Kit (S100A8/S100A9)

Recombinant|SimpleStep

ELISA - Mouse Calprotectin ELISA Kit (S100A8/S100A9) (AB263885)

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
Handling instructions

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Refer to SDS for further information.

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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Science signaling 17:eadh2783 PubMed38502732

2024

Exercise-induced BDNF promotes PPARδ-dependent reprogramming of lipid metabolism in skeletal muscle during exercise recovery.

Applications

Unspecified application

Species

Unspecified reactive species

Wing Suen Chan,Chun Fai Ng,Brian Pak Shing Pang,Miaojia Hang,Margaret Chui Ling Tse,Elsie Chit Yu Iu,Xin Ci Ooi,Xiuying Yang,Jason K Kim,Chi Wai Lee,Chi Bun Chan
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Product promise

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