GSK-J1, H3K27 histone demethylase inhibitor

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MW 389.4 Da, Purity >99%. Potent and selective H3K27 histone demethylase inhibitor (IC₅₀ = 60 nM, JMJD3). Inhibits UTX. Some activity for the H3K4me3/2/1 demethylases Jarid1b and Jarid1c (IC₅₀ values are 950 nM and 1.76 μM, respectively). No significant inhibitory activity against 100 protein kinases at a concentration of 30 μM. Anti-inflammatory effects.

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CT31, Cancer/testis antigen 31, DKFZp686A03225, DKFZp686A24246, DKFZp686P07111, DXS1272E, Histone demethylase JARID1A, Histone demethylase JARID1B, Histone demethylase JARID1C, Histone demethylase JMJD3, Histone demethylase UTX, JARID1A, JARID1B, JARID1C, JHDM2A, JHMD2A, JMJD1, JMJD1A, JMJD2E, JmjC domain containing protein SMCX, JmjC domain-containing histone demethylation protein 2A, JmjC domain-containing protein 3, Jumonji AT rich interactive domain 1B, Jumonji AT rich interactive domain 1C, Jumonji C domain containing histone demethylase 2A, Jumonji D3, Jumonji domain containing 1, Jumonji domain containing 1A, Jumonji domain containing 3, Jumonji domain containing 3 histone lysine demethylase, Jumonji domain-containing protein 1A, Jumonji domain-containing protein 3, Jumonji, AT rich interactive domain 1C (RBP2 like), Jumonji/ARID domain-containing protein 1A, Jumonji/ARID domain-containing protein 1B, Jumonji/ARID domain-containing protein 1C, KABUK2, KDM3A_HUMAN, KDM4D-like protein, KDM4DL, KDM5A_HUMAN, KDM5B_HUMAN, KDM5C_HUMAN, KDM6A_HUMAN, KDM6B_HUMAN, KIAA0346, KIAA0742, Lysine (K) specific demethylase 3A, Lysine (K) specific demethylase 5B, Lysine (K) specific demethylase 5C, Lysine (K) specific demethylase 6A, Lysine K specific demethylase 6A, Lysine K specific demethylase 6B, Lysine demethylase 5B, Lysine demethylase 6B, Lysine specific demethylase 4E, Lysine specific demethylase 6A ubiquitously transcribed tetratricopeptide repeat gene X chromosome, Lysine-specific demethylase 3A, Lysine-specific demethylase 5A, Lysine-specific demethylase 5B, Lysine-specific demethylase 5C, Lysine-specific demethylase 6A, Lysine-specific demethylase 6B, MGC141941, MRX13, MRXJ, MRXSCJ, MRXSJ, PLU-1, PPP1R98, PUT1, Protein SmcX, Protein Xe169, Protein phosphatase 1 regulatory subunit 98, RBBP-2, RBBP2H1A, RBP2 like, RBP2-H1, Retinoblastoma-binding protein 2, Retinoblastoma-binding protein 2 homolog 1, Retinoblastoma-binding protein 2 homolog 1A, SMCX, Selected cDNA on X, SmcX protein, Smcx homolog X chromosome, Smcy homolog X linked, TSGA, Testis specific protein A, UTX, Ubiquitously transcribed TPR gene on the X chromosome, Ubiquitously transcribed tetratricopeptide repeat X chromosome, Ubiquitously transcribed tetratricopeptide repeat protein X linked, Ubiquitously-transcribed TPR protein on the X chromosome, Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein, XE169, Xe169 protein, bA386N14.2, bA386N14.2 (ubiquitously transcribed X chromosome tetratricopeptide repeat protein (UTX), bA386N14.2 ubiquitously transcribed X chromosome tetratricopeptide repeat protein UTX, lysine (K)-specific demethylase 4E, putative DNA/chromatin binding motif, rbp2 like protein