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AB273432

GSK1904529A

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MW 852 Da, Purity >98%. Selective IGF-1R (IC50 = 27 nM in cell) and Insulin Receptor (IC50 = 25 nM) tyrosine kinase inhibitor in cell-free assays. Reversible, ATP-competitive (Ki = 1.6 nM). Blocks ligand induced autophosphorylation of IGF-1R and IR and activation of downstream Akt, IRS-1 and ERK signaling pathways. Inhibits proliferation of various cell lines. Induces G1 cell cycle arrest.
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Chemical Structure - GSK1904529A (AB273432)
  • Chemical Structure

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Chemical Structure - GSK1904529A (AB273432)

Chemical structure of GSK1904529A, 1089283-49-7

Key facts

CAS number

1089283-49-7

Purity

>98%

Form

Solid

form

Molecular weight

852 Da

Molecular formula

C<sub>4</sub><sub>4</sub>H<sub>4</sub><sub>7</sub>F<sub>2</sub>N<sub>9</sub>O<sub>5</sub>S

PubChem

25124816

Nature

Synthetic

Solubility

Soluble in DMSO to 50 mM

Biochemical name

N-(2,6-difluorophenyl)-5-[3-[2-[5-ethyl-2-methoxy-4-[4-(4-methylsulfonyl-1-piperazinyl)-1-piperidinyl]anilino]-4-pyrimidinyl]-2-imidazo[1,2-a]pyridinyl]-2-methoxybenzamide

Biological description

Selective IGF-1R (IC50 = 27 nM in cell) and Insulin Receptor (IC50 = 25 nM) tyrosine kinase inhibitor in cell-free assays. Reversible, ATP-competitive (Ki = 1.6 nM). Blocks ligand induced autophosphorylation of IGF-1R and IR and activation of downstream Akt, IRS-1 and ERK signaling pathways. Inhibits proliferation of various cell lines. Induces G1 cell cycle arrest.

Canonical smiles

CCC1=CC(=C(C=C1N2CCC(CC2)N3CCN(CC3)S(=O)(=O)C)OC)NC4=NC=CC(=N4)C5=C(N=C6N5C=CC=C6)C7=CC(=C(C=C7)OC)C(=O)NC8=C(C=CC=C8F)F

InChi

InChI=1S/C44H47F2N9O5S/c1-5-28-26-35(38(60-3)27-36(28)53-19-15-30(16-20-53)52-21-23-54(24-22-52)61(4,57)58)49-44-47-17-14-34(48-44)42-40(50-39-11-6-7-18-55(39)42)29-12-13-37(59-2)31(25-29)43(56)51-41-32(45)9-8-10-33(41)46/h6-14,17-18,25-27,30H,5,15-16,19-24H2,1-4H3,(H,51,56)(H,47,48,49)

InChiKey

MOSKATHMXWSZTQ-UHFFFAOYSA-N

IUPAC Name

N-(2,6-difluorophenyl)-5-[3-[2-[5-ethyl-2-methoxy-4-[4-(4-methylsulfonylpiperazin-1-yl)piperidin-1-yl]anilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]-2-methoxybenzamide

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Product details

For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
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Product protocols

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