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AB254316

GSK2578215A, LRRK2 inhibitor

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MW 399.4 Da, Purity >98%. Potent and highly selective LRRK2 inhibitor (IC50 = 8.9 and 10.1 nM for LRRK2[G2019S] mutant and wild-type LRRK2, respectively). Selective for LRRK2 in a panel of 460 kinases. Blood-brain barrier (BBB) permeable.
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Chemical Structure - GSK2578215A, LRRK2 inhibitor (AB254316)
  • Chemical Structure

Supplier Data

Chemical Structure - GSK2578215A, LRRK2 inhibitor (AB254316)

2D chemical structure image of ab254316, GSK2578215A, LRRK2 inhibitor.

Key facts

CAS number

1285515-21-0

Purity

>98%

Form

Solid

form

Molecular weight

399.4 Da

Molecular formula

C<sub>2</sub><sub>4</sub>H<sub>1</sub><sub>8</sub>FN<sub>3</sub>O<sub>2</sub>

PubChem

68107965

Nature

Synthetic

Solubility

Soluble in DMSO to >75 mM

Biochemical name

Benzamide, 5-(2-fluoro-4-pyridinyl)-2-(phenylmethoxy)-N-3-pyridinyl-

Biological description

Potent and highly selective LRRK2 inhibitor (IC50 = 8.9 and 10.1 nM for LRRK2[G2019S] mutant and wild-type LRRK2, respectively). Selective for LRRK2 in a panel of 460 kinases. Blood-brain barrier (BBB) permeable.

Canonical smiles

C1=CC=C(C=C1)COC2=C(C=C(C=C2)C3=CC(=NC=C3)F)C(=O)NC4=CN=CC=C4

InChi

InChI=1S/C24H18FN3O2/c25-23-14-19(10-12-27-23)18-8-9-22(30-16-17-5-2-1-3-6-17)21(13-18)24(29)28-20-7-4-11-26-15-20/h1-15H,16H2,(H,28,29)

InChiKey

WCIGMFCFPXZRMQ-UHFFFAOYSA-N

IUPAC Name

5-(2-fluoropyridin-4-yl)-2-phenylmethoxy-N-pyridin-3-ylbenzamide

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Product details

This product is manufactured by BioVision, an Abcam company and was previously called 2845 GSK2578215A. 2845-25 is the same size as the 25 mg size of ab254316.

Protect from air and light.

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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate long-term storage conditions
-20°C
Storage information
Store in the dark
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Product protocols

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Complementary Products

Biochemicals

AB254528

MLi-2, LRRK2 inhibitor

Chemical Structure - MLi-2, LRRK2 inhibitor (AB254528)

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Primary Antibodies

AB133474

Anti-LRRK2 antibody [MJFF2 (c41-2)]

KO Validated|RabMAb|Recombinant

Western blot - Anti-LRRK2 antibody [MJFF2 (c41-2)] (AB133474)

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Primary Antibodies

AB230261

Anti-RAB10 (phospho T73) antibody [MJF-R21]

20ul selling size|RabMAb|Recombinant|KO Validated

Western blot - Anti-RAB10 (phospho T73) antibody [MJF-R21] (AB230261)

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Biochemicals

AB144865

cGAMP disodium salt, STING agonist

Chemical Structure - cGAMP disodium salt, STING agonist (AB144865)

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