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MW 383.5 Da, Purity >98%. Highly potent, selective receptor interacting protein 3 (RIP3) inhibitor (IC50 = 1.3nM). Selectivty for RIP3 is over 100-fold more compared to other kinases. At high concentrations (3-10μM) can induce Caspase 8-mediated apoptosis. Increases HIF-1a expression after ischaemic injury *in vivo*. Blocks necroptosis in primary human neutrophils, TNF-induced necroptosis in HT-29 cells and inhibits TLR3- and DAI-induced death *in vitro.*.

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Key facts

CAS number
1346546-69-7
Purity
> 98%
Form
Solid
Molecular weight
383.5 Da
Molecular formula
C19H17N3O2S2
PubChem identifier
54674134
Nature
Synthetic

Target data

Recommended products

MW 383.5 Da, Purity >98%. Highly potent, selective receptor interacting protein 3 (RIP3) inhibitor (IC50 = 1.3nM). Selectivty for RIP3 is over 100-fold more compared to other kinases. At high concentrations (3-10μM) can induce Caspase 8-mediated apoptosis. Increases HIF-1a expression after ischaemic injury *in vivo*. Blocks necroptosis in primary human neutrophils, TNF-induced necroptosis in HT-29 cells and inhibits TLR3- and DAI-induced death *in vitro.*.

Key facts

Purity
> 98%
PubChem identifier
54674134
Solubility

Soluble in DMSO up to 50mM.

Biochemical name
N-(6-propan-2-ylsulfonylquinolin-4-yl)-1,3-benzothiazol-5-amine
Biological description

Highly potent, selective receptor interacting protein 3 (RIP3) inhibitor (IC50 = 1.3nM). Selectivty for RIP3 is over 100-fold more compared to other kinases. At high concentrations (3-10μM) can induce Caspase 8-mediated apoptosis. Increases HIF-1a expression after ischaemic injury *in vivo*. Blocks necroptosis in primary human neutrophils, TNF-induced necroptosis in HT-29 cells and inhibits TLR3- and DAI-induced death *in vitro.*

Canonical SMILES
CC(C)S(=O)(=O)C1=CC2=C(C=CN=C2C=C1)NC3=CC4=C(C=C3)SC=N4
InChI
InChI=1S/C19H17N3O2S2/c1-12(2)26(23,24)14-4-5-16-15(10-14)17(7-8-20-16)22-13-3-6-19-18(9-13)21-11-25-19/h3-12H,1-2H3,(H,20,22)
InChIKey
ZCDBTQNFAPKACC-UHFFFAOYSA-N
IUPAC name
N-(6-propan-2-ylsulfonylquinolin-4-yl)-1,3-benzothiazol-5-amine

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
The product can be stored for up to 12 months

Notes

Solutions in DMSO can be stored for up to 1 month.

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