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AB254395

GSK872, Necroptosis inhibitor

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(1 Publication)

MW 383.5 Da, Purity >98%. Highly potent, selective receptor interacting protein 3 (RIP3) inhibitor (IC50 = 1.3nM). Selectivty for RIP3 is over 100-fold more compared to other kinases. At high concentrations (3-10μM) can induce Caspase 8-mediated apoptosis. Increases HIF-1a expression after ischaemic injury *in vivo*. Blocks necroptosis in primary human neutrophils, TNF-induced necroptosis in HT-29 cells and inhibits TLR3- and DAI-induced death *in vitro.*.
1 Images
Chemical Structure - GSK872, Necroptosis inhibitor (AB254395)
  • Chemical Structure

Supplier Data

Chemical Structure - GSK872, Necroptosis inhibitor (AB254395)

2D chemical structure image of ab254395, GSK872, Necroptosis inhibitor

Key facts

CAS number

1346546-69-7

Purity

>98%

Form

Solid

form

Molecular weight

383.5 Da

Molecular formula

C<sub>1</sub><sub>9</sub>H<sub>1</sub><sub>7</sub>N<sub>3</sub>O<sub>2</sub>S<sub>2</sub>

PubChem

54674134

Nature

Synthetic

Solubility

Soluble in DMSO up to 50mM

Biochemical name

N-(6-propan-2-ylsulfonylquinolin-4-yl)-1,3-benzothiazol-5-amine

Biological description

Highly potent, selective receptor interacting protein 3 (RIP3) inhibitor (IC50 = 1.3nM). Selectivty for RIP3 is over 100-fold more compared to other kinases. At high concentrations (3-10μM) can induce Caspase 8-mediated apoptosis. Increases HIF-1a expression after ischaemic injury *in vivo*. Blocks necroptosis in primary human neutrophils, TNF-induced necroptosis in HT-29 cells and inhibits TLR3- and DAI-induced death *in vitro.*

Canonical smiles

CC(C)S(=O)(=O)C1=CC2=C(C=CN=C2C=C1)NC3=CC4=C(C=C3)SC=N4

InChi

InChI=1S/C19H17N3O2S2/c1-12(2)26(23,24)14-4-5-16-15(10-14)17(7-8-20-16)22-13-3-6-19-18(9-13)21-11-25-19/h3-12H,1-2H3,(H,20,22)

InChiKey

ZCDBTQNFAPKACC-UHFFFAOYSA-N

IUPAC Name

N-(6-propan-2-ylsulfonylquinolin-4-yl)-1,3-benzothiazol-5-amine

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Biochemicals

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Biochemicals

AB141421

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Secondary Antibodies

AB150113

Goat Anti-Mouse IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (AB150113)

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Product details

Solutions in DMSO can be stored for up to 1 month.
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
The product can be stored for up to 12 months
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell death & disease 13:662 PubMed35906211

2022

Hypoxia aggravates ferroptosis in RPE cells by promoting the Fenton reaction.

Applications

Unspecified application

Species

Unspecified reactive species

Yoshiyuki Henning,Ursula Sarah Blind,Safa Larafa,Johann Matschke,Joachim Fandrey
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