AB141871

GsMTx-4, mechanosensitive and stretch-activated ion channel inhibitor

Name: GsMTx-4, mechanosensitive and stretch-activated ion channel inhibitor (CAS 1209500-46-8) | Abcam
Brand: Abcam Limited
SKU: AB141871
Price: 345 USD
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(42 Publications)

GsMTx-4 (ab141871) inhibits mechanosensitive channels (MSCs) such as TRPC1, TRPC6 and Piezo channels. GsMTx4 also inhibits stretch-activated cation channels. MW 4096.

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Functional Studies - GsMTx-4, mechanosensitive and stretch-activated ion channel inhibitor (AB141871)

FuncS

Supplier Data

Functional Studies - GsMTx-4, mechanosensitive and stretch-activated ion channel inhibitor (AB141871)

GsMTx-4 (ab141870) inhibits Na_V1.7 channel currents expressed in Xenopus oocytes. Na_V1.7 currents were elicited by 100 ms voltage ramp from a holding potential of -100 mV to +30 mV, applied every 10 seconds using whole-cell voltage clamp technique. Left : Superimposed traces of Na_V1.7 currents before (black) and during (green) application of 500 nM GsMTx-4 (ab141870). Right : GsMTx-4 dose response inhibition of Na_V1.7 currents.

Chemical Structure - GsMTx-4, mechanosensitive and stretch-activated ion channel inhibitor (AB141871)

Chemical Structure

Lab

Chemical Structure - GsMTx-4, mechanosensitive and stretch-activated ion channel inhibitor (AB141871)

2D chemical structure image of ab141871, GsMTx-4, mechanosensitive and stretch-activated ion channel inhibitor

Key facts

CAS number

1209500-46-8

Form

Solid

form

Source

Grammostola rosea

Molecular weight

4096 Da

Molecular formula

C185H273N49O45S6

PubChem

90488987

Nature

Native

Solubility

Soluble in water to 1mg/ml

Biochemical name

H-Gly-DL-Cys(1)-DL-Leu-DL-Glu-DL-Phe-DL-Trp-DL-Trp-DL-Lys-DL-Cys(2)-DL-Asn-DL-Pro-DL-Asn-DL-Asp-DL-Asp-DL-Lys-DL-Cys(3)-DL-Cys(1)-DL-Arg-DL-Pro-DL-Lys-DL-Leu-DL-Lys-DL-Cys(2)-DL-Ser-DL-Lys-DL-Leu-DL-Phe-DL-Lys-DL-Leu-DL-Cys(3)-DL-Asn-DL-Phe-DL-Ser-DL-Phe-NH2

Canonical smiles

CC(C)CC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC2CSSCC3C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(CSSCC(C(=O)N1)NC(=O)CN)C(=O)NC(C(=O)N4CCCC4C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N3)CCCCN)CC(C)C)CCCCN)CCCNC(=N)N)NC(=O)C(NC(=O)C(NC

InChi

InChI=1S/C185H273N49O45S6/c1-98(2)72-121-160(255)203-114(54-27-33-65-188)156(251)229-141-96-284-283-95-140-178(273)225-134(84-147(195)239)184(279)234-71-39-60-144(234)182(277)224-131(83-146(194)238)170(265)222-133(86-151(245)246)172(267)223-132(85-150(243)244)171(266)206-116(56-29-35-67-190)158(253)230-142(97-285-282-94-139(177(272)221-130(82-145(193)237)169(264)218-127(79-105-46-19-12-20-47-105)166(261)226-136(91-236)174(269)211-120(152(196)247)76-102-40-13-9-14-41-102)231-163(258)124(75-101(7)8)214-153(248)112(52-25-31-63-186)204-164(259)125(77-103-42-15-10-16-43-103)217-162(257)123(74-100(5)6)213-154(249)113(53-26-32-64-187)207-173(268)135(90-235)227-179(141)274)180(275)232-138(176(271)210-119(58-37-69-199-185(197)198)183(278)233-70-38-59-143(233)181(276)209-117(155(250)212-121)57-30-36-68-191)93-281-280-92-137(202-148(240)87-192)175(270)215-122(73-99(3)4)161(256)208-118(61-62-149(241)242)159(254)216-126(78-104-44-17-11-18-45-104)165(260)219-129(81-107-89-201-111-51-24-22-49-109(107)111)168(263)220-128(80-106-88-200-110-50-23-21-48-108(106)110)167(262)205-115(157(252)228-140)55-28-34-66-189/h9-24,40-51,88-89,98-101,112-144,200-201,235-236H,25-39,52-87,90-97,186-192H2,1-8H3,(H2,193,237)(H2,194,238)(H2,195,239)(H2,196,247)(H,202,240)(H,203,255)(H,204,259)(H,205,262)(H,206,266)(H,207,268)(H,208,256)(H,209,276)(H,210,271)(H,211,269)(H,212,250)(H,213,249)(H,214,248)(H,215,270)(H,216,254)(H,217,257)(H,218,264)(H,219,260)(H,220,263)(H,221,272)(H,222,265)(H,223,267)(H,224,277)(H,225,273)(H,226,261)(H,227,274)(H,228,252)(H,229,251)(H,230,253)(H,231,258)(H,232,275)(H,241,242)(H,243,244)(H,245,246)(H4,197,198,199)

InChiKey

WVDNTWXIIKNMHY-UHFFFAOYSA-N

IUPAC Name

3-[77-[(2-aminoacetyl)amino]-30-[[4-amino-1-[[1-[[1-[(1-amino-1-oxo-3-phenylpropan-2-yl)amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1,4-dioxobutan-2-yl]carbamoyl]-22,36,45,54,60,95-hexakis(4-aminobutyl)-4,13-bis(2-amino-2-oxoethyl)-39,86-dibenzyl-69-(3-carbamimidamidopropyl)-16,19-bis(carboxymethyl)-48-(hydroxymethyl)-89,92-bis(1H-indol-3-ylmethyl)-33,42,57,80-tetrakis(2-methylpropyl)-2,3a,5,11,14,17,20,23,32,35,38,41,44,47,50,53,56,59,62,68,71,78,81,84,87,90,93,96-octacosaoxo-a,27,28,74,75,99-hexathia-2a,3,6,12,15,18,21,24,31,34,37,40,43,46,49,52,55,58,61,67,70,79,82,85,88,91,94,97-octacosazapentacyclo[49.46.4.225,72.06,10.063,67]trihectan-83-yl]propanoic acid

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Product details

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Properties and storage information

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate short-term storage conditions

-20°C

Appropriate long-term storage conditions

-20°C

Storage information

Store under desiccating conditions|The product can be stored for up to 12 months

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Product protocols

Visit the General protocols
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Publications (42)

Recent publications for all applications. Explore the full list and refine your search

Cell communication and signaling : CCS 23:193 PubMed40264231

2025

Mechanical cues rewire lipid metabolism and support chemoresistance in epithelial ovarian cancer cell lines OVCAR3 and SKOV3.

Applications

Unspecified application

Species

Unspecified reactive species

Martina Karasová,Maximilian Jobst,Denise Framke,Janice Bergen,Samuel Meier-Menches,Bernhard Keppler,Gunda Koellensperger,Jürgen Zanghellini,Christopher Gerner,Giorgia Del Favero

PloS one 20:e0317683 PubMed39841686

2025

GsMTx-4 combined with exercise improves skeletal muscle structure and motor function in rats with spinal cord injury.

Applications

Unspecified application

Species

Unspecified reactive species

Xin Zhang,Xinyu Liu,Qianxi Li,Chenyu Li,Xinyan Li,Jinghua Qian,Jianjun Li,Xuemei Li

Communications biology 8:96 PubMed39833492

2025

Piezo1 promotes vibration-induced vascular smooth muscle injury by regulating the NF-κB/p65 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Yingshan Zeng,Zhiquan Wu,Mengtian Xiong,Zhishan Liang,Ziyu Chen,Huimin Huang,Hongyu Yang,Qingsong Chen

Nature communications 15:10476 PubMed39668169

2024

An actin bracket-induced elastoplastic transition determines epithelial folding irreversibility.

Applications

Unspecified application

Species

Unspecified reactive species

Aki Teranishi,Misato Mori,Rihoko Ichiki,Satoshi Toda,Go Shioi,Satoru Okuda

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 11:e2405705 PubMed39514408

2024

Piezo1 Regulates Stiffness-Dependent DRG Axon Regeneration via Modifying Cytoskeletal Dynamics.

Applications

Unspecified application

Species

Unspecified reactive species

Mengshi Lei,Weiyou Wang,Hong Zhang,Jihong Gong,Hanmian Cai,Zhili Wang,Le Zhu,Xiaofei Yang,Shen Wang,Cong Ma

Theranostics 14:5965-5981 PubMed39346532

2024

Noninvasive closed-loop acoustic brain-computer interface for seizure control.

Applications

Unspecified application

Species

Unspecified reactive species

Junjie Zou,Houminji Chen,Xiaoyan Chen,Zhengrong Lin,Qihang Yang,Changjun Tie,Hong Wang,Lili Niu,Yanwu Guo,Hairong Zheng

Cellular and molecular life sciences : CMLS 81:331 PubMed39107572

2024

PIEZO1 targeting in macrophages boosts phagocytic activity and foam cell apoptosis in atherosclerosis.

Applications

Unspecified application

Species

Unspecified reactive species

Shirin Pourteymour,Jingxue Fan,Rakesh Kumar Majhi,Shuyuan Guo,Xin Sun,Zhen Huang,Ying Liu,Hanna Winter,Alexandra Bäcklund,Nikolaos-Taxiarchis Skenteris,Ekaterina Chernogubova,Olivera Werngren,Zhaolong Li,Josefin Skogsberg,Yuhuang Li,Ljubica Matic,Ulf Hedin,Lars Maegdefessel,Ewa Ehrenborg,Ye Tian,Hong Jin

Materials today. Bio 27:101147 PubMed39045313

2024

Synergistic effect of ultrasound and reinforced electrical environment by bioinspired periosteum for enhanced osteogenesis via immunomodulation of macrophage polarization through Piezo1.

Applications

Unspecified application

Species

Unspecified reactive species

Ting Jiang,Fei Yu,Yuqi Zhou,Ruomei Li,Mengting Zheng,Yangyang Jiang,Zhenxia Li,Jun Pan,Ningjuan Ouyang

iScience 27:109999 PubMed38883838

2024

Enhanced and sustained T cell activation in response to fluid shear stress.

Applications

Unspecified application

Species

Unspecified reactive species

Nicole S Sarna,Shanay H Desai,Benjamin G Kaufman,Natalie M Curry,Anne M Hanna,Michael R King

Matrix biology plus 22:100148 PubMed38803329

2024

Extracellular matrix stiffness mediates insulin secretion in pancreatic islets via mechanosensitive Piezo1 channel regulated Ca dynamics.

Applications

Unspecified application

Species

Unspecified reactive species

Chelsea G Johansen,Keifer Holcomb,Amit Sela,Stephanie Morrall,Daewon Park,Nikki L Farnsworth

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GsMTx-4, mechanosensitive and stretch-activated ion channel inhibitor

Functional Studies - GsMTx-4, mechanosensitive and stretch-activated ion channel inhibitor (AB141871)

Chemical Structure - GsMTx-4, mechanosensitive and stretch-activated ion channel inhibitor (AB141871)

Key facts

CAS number

Form

Source

Molecular weight

Molecular formula

PubChem

Nature

Solubility

Biochemical name

Canonical smiles

InChi

InChiKey

IUPAC Name

Product details

Properties and storage information

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Product protocols

Publications (42)

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Biochemicals

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