MW 563.1 Da, Purity >90%. G-protein-activating GTP analog. More hydrolysis resistant than GTP. Stimulates insulin release from pancreatic β-cells. Inhibits organelle transport along axonal microtubules. Induces exocytosis in vivo. .
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- iScience 26:1066032023Gαs slow conformational transition upon GTP binding and a novel Gαs regulator.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDonghoon Ahn,Davide Provasi,Nguyen Minh Duc,Jun Xu,Leslie Salas-Estrada,Aleksandar Spasic,Min Woo Yun,Juyeong Kang,Dongmin Gim,Jaecheol Lee,Yang Du,Marta Filizola,Ka Young ChungPubMed 37128611
- Nature immunology 21:880-8912020Guanylate-binding proteins convert cytosolic bacteria into caspase-4 signaling platforms.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMichal P Wandel et. al.PubMed 32541830
- The EMBO journal 39:e1049262020Direct binding of polymeric GBP1 to LPS disrupts bacterial cell envelope functions.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMiriam Kutsch et. al.PubMed 32510692
- Molecular cell 73:830-844.e122019The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJoanna R Kovalski et. al.PubMed 30639242
Key facts
- CAS number
- 94825-44-2
- Purity
- > 90%
- Form
- Solid
- Molecular weight
- 563.1 Da
- Molecular formula
- C10H12Li4N5O13P3S
- PubChem identifier
- 135445735
- Nature
- Synthetic
Target data
Recommended products
MW 563.1 Da, Purity >90%. G-protein-activating GTP analog. More hydrolysis resistant than GTP. Stimulates insulin release from pancreatic β-cells. Inhibits organelle transport along axonal microtubules. Induces exocytosis in vivo. .
Key facts
- CAS number
- 94825-44-2
- Purity
- > 90%
- Form
- Solid
- Molecular weight
- 563.1 Da
- Molecular formula
- C10H12Li4N5O13P3S
- PubChem identifier
- 135445735
- Nature
- Synthetic
- Solubility
Soluble in water to 100 mM.
- Biochemical name
- Guanosine 5'-(trihydrogen diphosphate), monoanhydride with phosphorothioic acid, tetralithium salt
- Biological description
G-protein-activating GTP analog. More hydrolysis resistant than GTP. Stimulates insulin release from pancreatic β-cells. Inhibits organelle transport along axonal microtubules. Induces exocytosis in vivo.
- Canonical SMILES
- [Li+].[Li+].[Li+].[Li+].C1=NC2=C(N1C3C(C(C(O3)COP(=O)([O-])OP(=O)([O-])OP(=S)([O-])[O-])O)O)N=C(NC2=O)N
- Isomeric SMILES
- [Li+].[Li+].[Li+].[Li+].C1=NC2=C(N1[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)([O-])OP(=O)([O-])OP(=S)([O-])[O-])O)O)N=C(NC2=O)N
- InChI
- InChI=1S/C10H16N5O13P3S.4Li/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(26-9)1-25-29(19,20)27-30(21,22)28-31(23,24)32;;;;/h2-3,5-6,9,16-17H,1H2,(H,19,20)(H,21,22)(H2,23,24,32)(H3,11,13,14,18);;;;/q;4*+1/p-4/t3-,5-,6-,9-;;;;/m1..../s1
- InChIKey
- AMQXJFWJOAWCPV-ZVQJTLEUSA-J
- IUPAC name
- tetralithium;[[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] dioxidophosphinothioyl phosphate
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
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1 product image
Chemical Structure - GTP-gamma-S, G-protein-activating GTP analog (ab146662)
2D chemical structure image of ab146662, GTP-gamma-S, G-protein-activating GTP analog
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