MW 308.4 Da, Purity >98%. Partial agonist at α7nACh receptors. Binds selectively to α7 subunits, with no significant activity seen at α2, α3 and α4. (EC50 = 10 μM in vitro (striatal slices)). Shown to elicit nootropic, neuroprotective and anti-inflammatory effects.
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- Cell insight 1:1000282022Activation of α7 nicotinic acetylcholine receptor promotes HIV-1 transcription.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJing Wen,Caiqi Zhao,Jie Chen,Shuting Song,Zhekai Lin,Shitao Xie,Huaxin Qi,Jianhua Wang,Xiao SuPubMed 37193048
- Neuroscience 483:40-512021Specificity of Varenicline in Blocking Mesolimbic Circuit Activation to Natural and Drug Rewards.Applications:Unspecified applicationReactive species:Unspecified reactive speciesNitsan Goldstein,Jamie R E Carty,J Nicholas BetleyPubMed 34923039
- Evidence-based complementary and alternative medic 2020:19140312020Effect of Electroacupuncture at Zusanli (ST36) on Sepsis Induced by Cecal Ligation Puncture and Its Relevance to Spleen.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDong-Ping Xie et. al.PubMed 33082818
- Molecular medicine (Cambridge, Mass.) 26:632020The α7 nicotinic acetylcholine receptor agonist, GTS-21, attenuates hyperoxia-induced acute inflammatory lung injury by alleviating the accumulation of HMGB1 in the airways and the circulation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRavikumar A Sitapara et. al.PubMed 32600307
- Stem cell research & therapy 11:2302020Vagal-α7nAChR signaling promotes lung stem cells regeneration via fibroblast growth factor 10 during lung injury repair.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXiaoyan Chen et. al.PubMed 32522255
- Journal of neuroinflammation 14:2342017Pharmacologic activation of cholinergic alpha7 nicotinic receptors mitigates depressive-like behavior in a mouse model of chronic stress.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDan Zhao et. al.PubMed 29197398
- Molecular medicine (Cambridge, Mass.) 23:34-392017Deficiency of α7 nicotinic acetylcholine receptor attenuates bleomycin-induced lung fibrosis in mice.
Key facts
- CAS number
- 148372-04-7
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 308.4 Da
- Molecular formula
- C19H20N2O2
- PubChem identifier
- 5310985
- Nature
- Synthetic
Recommended products
MW 308.4 Da, Purity >98%. Partial agonist at α7nACh receptors. Binds selectively to α7 subunits, with no significant activity seen at α2, α3 and α4. (EC50 = 10 μM in vitro (striatal slices)). Shown to elicit nootropic, neuroprotective and anti-inflammatory effects.
Key facts
- CAS number
- 148372-04-7
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 308.4 Da
- Molecular formula
- C19H20N2O2
- PubChem identifier
- 5310985
- Nature
- Synthetic
- Solubility
Soluble in water to 100 mM.
Soluble in DMSO to 100 mM.
- Biochemical name
- 3-(2,4-Dimethoxybenzylidene)anabaseine
- Biological description
Partial agonist at α7nACh receptors. Binds selectively to α7 subunits, with no significant activity seen at α2, α3 and α4. (EC50 = 10 μM in vitro (striatal slices)). Shown to elicit nootropic, neuroprotective and anti-inflammatory effects.
- Canonical SMILES
- COC1=CC(=C(C=C1)C=C2CCCN=C2C3=CN=CC=C3)OC
- Isomeric SMILES
- COC1=CC(=C(C=C1)/C=C/2\CCCN=C2C3=CN=CC=C3)OC
- InChI
- InChI=1S/C19H20N2O2/c1-22-17-8-7-14(18(12-17)23-2)11-15-5-4-10-21-19(15)16-6-3-9-20-13-16/h3,6-9,11-13H,4-5,10H2,1-2H3/b15-11+
- InChIKey
- RPYWXZCFYPVCNQ-RVDMUPIBSA-N
- IUPAC name
- 3-[(5E)-5-[(2,4-dimethoxyphenyl)methylidene]-3,4-dihydro-2H-pyridin-6-yl]pyridine
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- +4°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
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1 product image
Chemical Structure - GTS-21 dihydrochloride (DMBX-A), alpha7 Nicotinic acetylcholine receptor agonist (ab120560)
2D chemical structure image of ab120560, GTS-21 dihydrochloride (DMBX-A), alpha7 Nicotinic acetylcholine receptor agonist
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