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AB120560

GTS-21 dihydrochloride (DMBX-A), alpha7 Nicotinic acetylcholine receptor agonist

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(8 Publications)

MW 308.4 Da, Purity >98%. Partial agonist at α7nACh receptors. Binds selectively to α7 subunits, with no significant activity seen at α2, α3 and α4. (EC50 = 10 μM in vitro (striatal slices)). Shown to elicit nootropic, neuroprotective and anti-inflammatory effects.
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Chemical Structure - GTS-21 dihydrochloride (DMBX-A), alpha7 Nicotinic acetylcholine receptor agonist (AB120560)
  • Chemical Structure

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Chemical Structure - GTS-21 dihydrochloride (DMBX-A), alpha7 Nicotinic acetylcholine receptor agonist (AB120560)

2D chemical structure image of ab120560, GTS-21 dihydrochloride (DMBX-A), alpha7 Nicotinic acetylcholine receptor agonist

Key facts

CAS number

148372-04-7

Purity

>98%

Form

Solid

form

Molecular weight

308.4 Da

Molecular formula

C<sub>1</sub><sub>9</sub>H<sub>2</sub><sub>0</sub>N<sub>2</sub>O<sub>2</sub>

PubChem

5310985

Nature

Synthetic

Solubility

Soluble in water to 100 mM

Soluble in DMSO to 100 mM

Biochemical name

3-(2,4-Dimethoxybenzylidene)anabaseine

Biological description

Partial agonist at α7nACh receptors. Binds selectively to α7 subunits, with no significant activity seen at α2, α3 and α4. (EC50 = 10 μM in vitro (striatal slices)). Shown to elicit nootropic, neuroprotective and anti-inflammatory effects.

Canonical smiles

COC1=CC(=C(C=C1)C=C2CCCN=C2C3=CN=CC=C3)OC

Isomeric smiles

COC1=CC(=C(C=C1)/C=C/2\CCCN=C2C3=CN=CC=C3)OC

InChi

InChI=1S/C19H20N2O2/c1-22-17-8-7-14(18(12-17)23-2)11-15-5-4-10-21-19(15)16-6-3-9-20-13-16/h3,6-9,11-13H,4-5,10H2,1-2H3/b15-11+

InChiKey

RPYWXZCFYPVCNQ-RVDMUPIBSA-N

IUPAC Name

3-[(5E)-5-[(2,4-dimethoxyphenyl)methylidene]-3,4-dihydro-2H-pyridin-6-yl]pyridine

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (8)

Recent publications for all applications. Explore the full list and refine your search

Journal of medical virology 96:e29768 PubMed38978388

2024

Vagal-α7 nicotinic acetylcholine receptor signaling exacerbates influenza severity by promoting lung epithelial cell infection.

Applications

Unspecified application

Species

Unspecified reactive species

Caiqi Zhao,Mengyao Pan,Jie Chen,Ling Li,Yan Zhang,Wenjun Liu,Michael A Matthay,Haichao Wang,Xia Jin,Jin-Fu Xu,Xiao Su

Cell insight 1:100028 PubMed37193048

2022

Activation of α7 nicotinic acetylcholine receptor promotes HIV-1 transcription.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Wen,Caiqi Zhao,Jie Chen,Shuting Song,Zhekai Lin,Shitao Xie,Huaxin Qi,Jianhua Wang,Xiao Su

Neuroscience 483:40-51 PubMed34923039

2021

Specificity of Varenicline in Blocking Mesolimbic Circuit Activation to Natural and Drug Rewards.

Applications

Unspecified application

Species

Unspecified reactive species

Nitsan Goldstein,Jamie R E Carty,J Nicholas Betley

Evidence-based complementary and alternative medic 2020:1914031 PubMed33082818

2020

Effect of Electroacupuncture at Zusanli (ST36) on Sepsis Induced by Cecal Ligation Puncture and Its Relevance to Spleen.

Applications

Unspecified application

Species

Unspecified reactive species

Dong-Ping Xie,Geng-Biao Zhou,Rui-Lan Chen,Xiao-Lian Qin,Jiong-Dong Du,Yan Zhang,Yan-Na Weng,Shu-Tao Mai,Fang Lai,Yun Han

Molecular medicine (Cambridge, Mass.) 26:63 PubMed32600307

2020

The α7 nicotinic acetylcholine receptor agonist, GTS-21, attenuates hyperoxia-induced acute inflammatory lung injury by alleviating the accumulation of HMGB1 in the airways and the circulation.

Applications

Unspecified application

Species

Unspecified reactive species

Ravikumar A Sitapara,Alex G Gauthier,Sergio I Valdés-Ferrer,Mosi Lin,Vivek Patel,Mao Wang,Ashley T Martino,Jeanette C Perron,Charles R Ashby,Kevin J Tracey,Valentin A Pavlov,Lin L Mantell

Stem cell research & therapy 11:230 PubMed32522255

2020

Vagal-α7nAChR signaling promotes lung stem cells regeneration via fibroblast growth factor 10 during lung injury repair.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoyan Chen,Caiqi Zhao,Cuiping Zhang,Qingmei Li,Jie Chen,Lianping Cheng,Jian Zhou,Xiao Su,Yuanlin Song

Journal of neuroinflammation 14:234 PubMed29197398

2017

Pharmacologic activation of cholinergic alpha7 nicotinic receptors mitigates depressive-like behavior in a mouse model of chronic stress.

Applications

Unspecified application

Species

Unspecified reactive species

Dan Zhao,Xulin Xu,Linna Pan,Wei Zhu,Xiaopei Fu,Lianjun Guo,Qing Lu,Jian Wang

Molecular medicine (Cambridge, Mass.) 23:34-39 PubMed28283678

2017

Deficiency of α7 nicotinic acetylcholine receptor attenuates bleomycin-induced lung fibrosis in mice.

Applications

Unspecified application

Species

Mouse

Peiyu Sun,Ling Li,Caiqi Zhao,Mengyao Pan,Zhikang Qian,Xiao Su
View all publications
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