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AB143497

Guggulsterone (pregna-4,17-diene-3,16-dione), steroid receptor antagonist

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MW 312.4 Da, Purity >98%. Broad spectrum steroid receptor antagonist (Ki values are 39, 224 and 240 nM for mineralocorticoid, glucocorticoid and androgen receptors respectively). Partial progesterone receptor agonist (Ki = 201 nM). Shows hypoglycemic and hypolipidemic effects in vivo. Orally active.
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Chemical Structure - Guggulsterone (pregna-4,17-diene-3,16-dione), steroid receptor antagonist (AB143497)
  • Chemical Structure

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Chemical Structure - Guggulsterone (pregna-4,17-diene-3,16-dione), steroid receptor antagonist (AB143497)

2D chemical structure image of ab143497, Guggulsterone (pregna-4,17-diene-3,16-dione), steroid receptor antagonist

Key facts

CAS number

95975-55-6

Purity

>98%

Molecular weight

312.4 Da

Molecular formula

C<sub>2</sub><sub>1</sub>H<sub>2</sub><sub>8</sub>O<sub>2</sub>

PubChem

146898

Nature

Synthetic

Solubility

Soluble in ethanol to 10 mM (with warming)

Biochemical name

Pregna-4,17(20)-diene-3,16-dione

Biological description

Broad spectrum steroid receptor antagonist (Ki values are 39, 224 and 240 nM for mineralocorticoid, glucocorticoid and androgen receptors respectively). Partial progesterone receptor agonist (Ki = 201 nM). Shows hypoglycemic and hypolipidemic effects in vivo. Orally active.

Canonical smiles

CC=C1C(=O)CC2C1(CCC3C2CCC4=CC(=O)CCC34C)C

Isomeric smiles

CC=C1C(=O)C[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)C

InChi

InChI=1S/C21H28O2/c1-4-16-19(23)12-18-15-6-5-13-11-14(22)7-9-20(13,2)17(15)8-10-21(16,18)3/h4,11,15,17-18H,5-10,12H2,1-3H3/t15-,17+,18+,20+,21-/m1/s1

InChiKey

WDXRGPWQVHZTQJ-NRJJLHBYSA-N

IUPAC Name

(8R,9S,10R,13S,14S)-17-ethylidene-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15-decahydrocyclopenta[a]phenanthrene-3,16-dione

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate long-term storage conditions
Ambient
Storage information
The product can be stored for up to 12 months
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Product protocols

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