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AB141299

GW 3965 hydrochloride, LXR agonist

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(1 Publication)

MW 618.5 Da, Purity >98%. Potent and selective LXR agonist (EC50 values are 190 and 30 nM at hLXRα and hLXRβ, respectively). Reduces Ang II-mediated vasopressor responses in rats. Orally active. Anti-inflammatory, Hypolipidemic and antitumor agent. Active in vivo and in vitro.
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Chemical Structure - GW 3965 hydrochloride, LXR agonist (AB141299)
  • Chemical Structure

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Chemical Structure - GW 3965 hydrochloride, LXR agonist (AB141299)

2D chemical structure image of ab141299, GW 3965 hydrochloride, LXR agonist

Key facts

CAS number

405911-17-3

Purity

>98%

Form

Solid

form

Molecular weight

618.5 Da

Molecular formula

C<sub>3</sub><sub>3</sub>H<sub>3</sub><sub>2</sub>Cl<sub>2</sub>F<sub>3</sub>NO<sub>3</sub>

PubChem

16078973

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Soluble in ethanol to 25 mM

Biochemical name

2-(3-(3-((2-Chloro-3-(trifluoromethyl)benzyl)(2,2-diphenylethyl)amino)propoxy)phenyl)acetic acid hydrochloride

Biological description

Potent and selective LXR agonist (EC50 values are 190 and 30 nM at hLXRα and hLXRβ, respectively). Reduces Ang II-mediated vasopressor responses in rats. Orally active. Anti-inflammatory, Hypolipidemic and antitumor agent. Active in vivo and in vitro.

Canonical smiles

C1=CC=C(C=C1)C(CN(CCCOC2=CC=CC(=C2)CC(=O)O)CC3=C(C(=CC=C3)C(F)(F)F)Cl)C4=CC=CC=C4.Cl

InChi

InChI=1S/C33H31ClF3NO3.ClH/c34-32-27(15-8-17-30(32)33(35,36)37)22-38(18-9-19-41-28-16-7-10-24(20-28)21-31(39)40)23-29(25-11-3-1-4-12-25)26-13-5-2-6-14-26;/h1-8,10-17,20,29H,9,18-19,21-23H2,(H,39,40);1H

InChiKey

NMPUWJFHNOUNQU-UHFFFAOYSA-N

IUPAC Name

2-[3-[3-[[2-chloro-3-(trifluoromethyl)phenyl]methyl-(2,2-diphenylethyl)amino]propoxy]phenyl]acetic acid;hydrochloride

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Toxicology letters 296:31-38 PubMed30036686

2018

Placental mechanism of prenatal nicotine exposure-reduced blood cholesterol levels in female fetal rats.

Applications

Unspecified application

Species

Unspecified reactive species

Guohui Zhang,Jin Zhou,Wen Huang,Luting Yu,Yuanzhen Zhang,Hui Wang
View all publications
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