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MW 275.3 Da, Purity >99%. Potent, selective TrKA tyrosine kinase inhibitor (IC50 = 2 nM). Displays >100-fold selectivity over a range of other kinases. Antineoplastic effects.

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Images

Chemical Structure - GW-441756 hydrochloride, TrKA receptor tyrosine kinase inhibitor (AB141051), expandable thumbnail

Publications

Key facts

CAS number

504433-24-3

Purity

> 99%

Form

Solid

Molecular weight

275.3 Da

Molecular formula

C17H13N3O

PubChem identifier

9943465

Nature

Synthetic

Alternative names

Recommended products

MW 275.3 Da, Purity >99%. Potent, selective TrKA tyrosine kinase inhibitor (IC50 = 2 nM). Displays >100-fold selectivity over a range of other kinases. Antineoplastic effects.

Key facts

Purity

> 99%

PubChem identifier

9943465

Solubility

Soluble in DMSO to 50 mM.

Biochemical name

1,3-Dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2H-pyrrolo[3,2-b]pyridin-2-one

Biological description

Potent, selective TrKA tyrosine kinase inhibitor (IC50 = 2 nM). Displays >100-fold selectivity over a range of other kinases. Antineoplastic effects.

Canonical SMILES

CN1C=C(C2=CC=CC=C21)C=C3C4=C(C=CC=N4)NC3=O

Isomeric SMILES

CN1C=C(C2=CC=CC=C21)/C=C\3/C4=C(C=CC=N4)NC3=O

InChI

InChI=1S/C17H13N3O/c1-20-10-11(12-5-2-3-7-15(12)20)9-13-16-14(19-17(13)21)6-4-8-18-16/h2-10H,1H3,(H,19,21)/b13-9-

InChIKey

NXNQLECPAXXYTR-LCYFTJDESA-N

IUPAC name

(3Z)-3-[(1-methylindol-3-yl)methylidene]-1H-pyrrolo[3,2-b]pyridin-2-one

Storage

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate short-term storage conditions

Ambient

Appropriate long-term storage conditions

Ambient

Storage information

The product can be stored for up to 12 months

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Interferon beta (IFN-β) and TrkA are distinct but engaging biological targets. IFN-β is a cytokine approximately 20 kDa mainly expressed in fibroblasts monocytes and dendritic cells. It binds to IFNAR1 and IFNAR2 receptors leading to a signal transduction essential in antiviral defense. TrkA or tropomyosin receptor kinase A is a high-affinity receptor for nerve growth factor (NGF) with a molecular weight of about 140 kDa widely expressed in neurons. It plays an important role in the development and function of the nervous system.

Biological function summary

IFN-β initiates immune responses against viral infections contributing to inflammation regulation. It activates the JAK-STAT pathway and forms complexes with other cytokines to enhance antiviral activity. TrkA mediates survival and differentiation of neurons by signaling through NGF participating in neuronal cell differentiation and apoptosis prevention. This receptor operates in a receptor-ligand complex pivotal for neuronal signaling.

Pathways

Both IFN-β and TrkA involve critical signaling cascades. IFN-β engages predominantly through the JAK-STAT signaling pathway which is vital for immune response. TrkA participates in the MAPK/ERK and PI3K/Akt pathways connecting closely with proteins like RAF and AKT supporting survival and growth. These pathways highlight their roles in maintaining cellular health and functionality.

Associated diseases and disorders

IFN-β shows relevance in multiple sclerosis due to its ability to modulate immune responses offering therapeutic avenues. TrkA's involvement with congenital insensitivity to pain with anhidrosis (CIPA) highlights its importance in neural health and pain perception. Both could link to other proteins; for instance reduced IFN-β can be observed in some viral infections while TrkA's interaction with NGF is an important factor in neuroregenerative disorders.

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1 product image

  • Chemical Structure - GW-441756 hydrochloride, TrKA receptor tyrosine kinase inhibitor (ab141051), expandable thumbnail

    Chemical Structure - GW-441756 hydrochloride, TrKA receptor tyrosine kinase inhibitor (ab141051)

    2D chemical structure image of ab141051, GW-441756 hydrochloride, TrKA receptor tyrosine kinase inhibitor

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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