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MW 366.4 Da, Purity >99%. Selective cFMS (colony stimulating factor 1) RTK inhibitor. Inhibits monocyte growth in vitro (IC50 = 0.2 μM) and LPS-induced TNF-α production in vivo. Inhibits macrophage infiltration of the CNS. Orally active. Cell-permeable.

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Images

Chemical Structure - GW2580 (DMSO solution), cFMS RTK inhibitor (AB146624), expandable thumbnail

Key facts

CAS number
870483-87-7
Purity
> 99%
Form
Liquid
Molecular weight
366.4 Da
Molecular formula
C20H22N4O3
PubChem identifier
11617559
Nature
Synthetic

Target data

Alternative names

C-FMS, CD 115, CD115 antigen, CSF-1 receptor, CSF1R_HUMAN, CSFR, Colony stimulating factor 1 receptor, Colony stimulating factor I receptor, EC 2.7.10.1, FIM 2, FMS, FMS proto oncogene, HDLS, M-CSF Receptor, M-CSF-R, Macrophage colony stimulating factor I receptor, Macrophage colony-stimulating factor 1 receptor, McDonough feline sarcoma viral (v fms) oncogene homolog, Oncogen FMS, Proto-oncogene c-Fms, V-FMS McDonough feline sarcoma viral oncogen homolog, formerly

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MW 366.4 Da, Purity >99%. Selective cFMS (colony stimulating factor 1) RTK inhibitor. Inhibits monocyte growth in vitro (IC50 = 0.2 μM) and LPS-induced TNF-α production in vivo. Inhibits macrophage infiltration of the CNS. Orally active. Cell-permeable.

Key facts

Purity
> 99%
PubChem identifier
11617559
Biochemical name
5-(3-Methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine
Biological description

Selective cFMS (colony stimulating factor 1) RTK inhibitor. Inhibits monocyte growth in vitro (IC50 = 0.2 μM) and LPS-induced TNF-α production in vivo. Inhibits macrophage infiltration of the CNS. Orally active. Cell-permeable.

Canonical SMILES
COC1=CC=C(C=C1)COC2=C(C=C(C=C2)CC3=CN=C(N=C3N)N)OC
InChI
InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24)
InChIKey
MYQAUKPBNJWPIE-UHFFFAOYSA-N
IUPAC name
5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store in the dark, Store under desiccating conditions, This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes

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1 product image

  • Chemical Structure - GW2580 (DMSO solution), cFMS RTK inhibitor (ab146624), expandable thumbnail

    Chemical Structure - GW2580 (DMSO solution), cFMS RTK inhibitor (ab146624)

    2D chemical structure image of ab146624, GW2580 (DMSO solution), cFMS RTK inhibitor

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Product protocols

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