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AB146624

GW2580 (DMSO solution), cFMS RTK inhibitor

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MW 366.4 Da, Purity >99%. Selective cFMS (colony stimulating factor 1) RTK inhibitor. Inhibits monocyte growth in vitro (IC50 = 0.2 μM) and LPS-induced TNF-α production in vivo. Inhibits macrophage infiltration of the CNS. Orally active. Cell-permeable.
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Chemical Structure - GW2580 (DMSO solution), cFMS RTK inhibitor (AB146624)
  • Chemical Structure

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Chemical Structure - GW2580 (DMSO solution), cFMS RTK inhibitor (AB146624)

2D chemical structure image of ab146624, GW2580 (DMSO solution), cFMS RTK inhibitor

Key facts

CAS number

870483-87-7

Purity

>99%

Form

Liquid

form

Molecular weight

366.4 Da

Molecular formula

C<sub>2</sub><sub>0</sub>H<sub>2</sub><sub>2</sub>N<sub>4</sub>O<sub>3</sub>

PubChem

11617559

Nature

Synthetic

Biochemical name

5-(3-Methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine

Biological description

Selective cFMS (colony stimulating factor 1) RTK inhibitor. Inhibits monocyte growth in vitro (IC50 = 0.2 μM) and LPS-induced TNF-α production in vivo. Inhibits macrophage infiltration of the CNS. Orally active. Cell-permeable.

Canonical smiles

COC1=CC=C(C=C1)COC2=C(C=C(C=C2)CC3=CN=C(N=C3N)N)OC

InChi

InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24)

InChiKey

MYQAUKPBNJWPIE-UHFFFAOYSA-N

IUPAC Name

5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine

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Complementary Products

Biochemicals

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Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

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Biochemicals

AB142096

GW 2580, cFMS RTK inhibitor

Chemical Structure - GW 2580, cFMS RTK inhibitor (AB142096)

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Primary Antibodies

AB15828

Anti-V5 tag antibody

Lab Essentials

Western blot - Anti-V5 tag antibody (AB15828)

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store in the dark|Store under desiccating conditions|This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes
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Product protocols

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