GW542573X, KCa2 channel activator

Key facts

CAS number

660846-41-3

Purity

>99%

Form

Solid

form

Molecular weight

364.4 Da

Molecular formula

C₁₉H₂₈N₂O₅

PubChem

24885053

Nature

Synthetic

Solubility

Soluble in ethanol to 100 mM

Biochemical name

Tert-butyl 4-({[(2-methoxyphenyl)carbamoyl]oxy}methyl)piperidine-1-carboxylate

Biological description

Novel activator of KCa2 ('SK') channels. Selective SK1 channel activator (EC50 = 8.2 μM). First true activator of KCa2.x and KCa3.1 channels; displays 100-fold greater selectivity for KCa2.x over KCa3.1.

Canonical smiles

CC(C)(C)OC(=O)N1CCC(CC1)COC(=O)NC2=CC=CC=C2OC

InChi

InChI=1S/C19H28N2O5/c1-19(2,3)26-18(23)21-11-9-14(10-12-21)13-25-17(22)20-15-7-5-6-8-16(15)24-4/h5-8,14H,9-13H2,1-4H3,(H,20,22)

InChiKey

SAXGSDIZIYFNKD-UHFFFAOYSA-N

IUPAC Name

tert-butyl 4-[(2-methoxyphenyl)carbamoyloxymethyl]piperidine-1-carboxylate