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MW 364.4 Da, Purity >99%. Novel activator of KCa2 ('SK') channels. Selective SK1 channel activator (EC50 = 8.2 μM). First true activator of KCa2.x and KCa3.1 channels; displays 100-fold greater selectivity for KCa2.x over KCa3.1.

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Images

Chemical Structure - GW542573X, KCa2 channel activator (AB120502), expandable thumbnail

Key facts

CAS number
660846-41-3
Purity
> 99%
Form
Solid
Molecular weight
364.4 Da
Molecular formula
C19H28N2O5
PubChem identifier
24885053
Nature
Synthetic

Target data

Recommended products

MW 364.4 Da, Purity >99%. Novel activator of KCa2 ('SK') channels. Selective SK1 channel activator (EC50 = 8.2 μM). First true activator of KCa2.x and KCa3.1 channels; displays 100-fold greater selectivity for KCa2.x over KCa3.1.

Key facts

Purity
> 99%
PubChem identifier
24885053
Solubility

Soluble in ethanol to 100 mM.

Biochemical name
Tert-butyl 4-({[(2-methoxyphenyl)carbamoyl]oxy}methyl)piperidine-1-carboxylate
Biological description

Novel activator of KCa2 ('SK') channels. Selective SK1 channel activator (EC50 = 8.2 μM). First true activator of KCa2.x and KCa3.1 channels; displays 100-fold greater selectivity for KCa2.x over KCa3.1.

Canonical SMILES
CC(C)(C)OC(=O)N1CCC(CC1)COC(=O)NC2=CC=CC=C2OC
InChI
InChI=1S/C19H28N2O5/c1-19(2,3)26-18(23)21-11-9-14(10-12-21)13-25-17(22)20-15-7-5-6-8-16(15)24-4/h5-8,14H,9-13H2,1-4H3,(H,20,22)
InChIKey
SAXGSDIZIYFNKD-UHFFFAOYSA-N
IUPAC name
tert-butyl 4-[(2-methoxyphenyl)carbamoyloxymethyl]piperidine-1-carboxylate

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions

Notes

Supplied in ethanol (25 mg/ml). Please note this compound is unstable as the solid form and unstable in DMSO

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1 product image

  • Chemical Structure - GW542573X, KCa2 channel activator (ab120502), expandable thumbnail

    Chemical Structure - GW542573X, KCa2 channel activator (ab120502)

    2D chemical structure image of ab120502, GW542573X, KCa2 channel activator

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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