MW 502.8 Da, Purity >99%. Highly potent, selective PPARα agonist (EC50 values are 6, 1100 and 6200 nM for PPARα, PPARγ and PPARδ respectively). Pharmacologically active in vivo.
View Alternative Names
(R)-limonene 6-monooxygenase, (S)-limonene 6-monooxygenase, (S)-limonene 7-monooxygenase, 1,8-cineole 2-exo-monooxygenase, Albendazole monooxygenase, Albendazole sulfoxidase, Atherosclerosis, susceptibility to, included, BAZ2B_HUMAN, Bromodomain adjacent to zinc finger domain 2B, Bromodomain adjacent to zinc finger domain protein 2B, CBX, CBX1_HUMAN, CP2C9_HUMAN, CP33, CP34, CP3A4_HUMAN, CPC9, CYP2C, CYP2C10, CYP3, CYP3A, CYP3A3, CYP3A4, CYPIIC9, CYPIIIA3, CYPIIIA4, Chromobox 1, Chromobox homolog 1 (HP1 beta homolog Drosophila ), Chromobox protein homolog 1, Cytochrome P-450MP, Cytochrome P450 2C9, Cytochrome P450 3A3, Cytochrome P450 3A4, Cytochrome P450 HLp, Cytochrome P450 MP-4, Cytochrome P450 MP-8, Cytochrome P450 NF-25, Cytochrome P450 PB-1, Cytochrome P450 family 3 subfamily A polypeptide 4, Cytochrome P450 subfamily IIIA polypeptide 4, Cytochrome P450, family 2, subfamily C, polypeptide 9, Cytochrome P450-PCN1, D(1A) dopamine receptor, D1A dopamine receptor, DADR, DINB protein, DINB1, DINP, DKFZp434H071, DKFZp686N23123, DKFZp762I0516, DNA damage inducible protein b, DNA polymerase eta, DNA polymerase iota, DNA polymerase kappa, DNA replication inhibitor, DRD 1A, DRD1_HUMAN, DinB homolog 1 (E. coli), Dopamine D1 receptor, Drosophila HP1 beta, ER, ER-alpha, ER-beta, ER[a], ER[b], ESR, ESR B, ESR BETA, ESR1_HUMAN, ESRA, ESTR B, Era, Erb, Erb2, Estr, Estra, Estradiol Receptor alpha, Estradiol Receptor beta, Estradiol receptor, Estrogen Receptor 1, Estrogen Receptor 2, Estrogen receptor, Estrogen receptor 1 (alpha), Estrogen receptor 2 (ER beta), Estrogen receptor 2 ER beta, Estrogen receptor alpha, Estrogen receptor beta 4, Estrogen resistance, included, Eta 2, FLJ00280, FLJ00318, FLJ16020, FLJ16395, FLJ16733, FLJ21978, FLJ45644, GCCR, GCN5 general control of amino acid synthesis 5 like 2, GCRST, GCR_HUMAN, GEMI_HUMAN, GMNN, GR, Geminin, Geminin DNA replication inhibitor, Glucocorticoid inducible P450, Glucocorticoid receptor, Grl1, HDL cholesterol, augmented response of, to hormone replacement, included, HLP, HP1 beta, HP1 beta homolog, HP1 beta homolog Drosophila, HP1, Drosophila. homolog of, beta, HP1Hs beta, HSMPP8, Heterochromatin protein 1 beta, Heterochromatin protein 1 homolog beta, Heterochromatin protein p25, Human heterochromatin protein p25 mRNA complete cds, M-phase phosphoprotein 8, M-phase phosphoprotein, mpp, M-phase phosphoprotein, mpp8, M31, MGC102720, MGC126680, MGC149605, MGC2237, MGC2452, MGC88320, MOD 1, MPHOSPH8, MPP8_HUMAN, Microsomal monooxygenase, Modifier 1 protein, Myocardial infarction, susceptibility to, included, NF 25, NR1C1, NR1C3, NR2B1, NR3A1, NR3A2, Nifedipine oxidase, Nuclear receptor subfamily 1 group C member 1, Nuclear receptor subfamily 1 group C member 3, Nuclear receptor subfamily 2 group B member 1, Nuclear receptor subfamily 3 group A member 1, Nuclear receptor subfamily 3 group A member 2, Nuclear receptor subfamily 3 group C member 1, OTTHUMP00000017718, OTTHUMP00000017719, OTTHUMP00000020135, OTTHUMP00000022510, OTTHUMP00000039393, OTTHUMP00000162897, OTTHUMP00000162898, OTTHUMP00000197740, OTTHUMP00000197741, P450 III steroid inducible, P450 MP, P450 PB 1, P450 PCN1, P450, family III, P450C3, P450IIC9, POLH_HUMAN, POLI_HUMAN, POLK_HUMAN, POLQ, PPAR, PPAR-alpha, PPAR-gamma, PPARA_HUMAN, PPARG2, PPARG_HUMAN, Peroxisome proliferative activated receptor alpha, Peroxisome proliferator activated receptor gamma 2, Peroxisome proliferator-activated receptor alpha, Peroxisome proliferator-activated receptor gamma, Polymerase (DNA directed) iota, Polymerase (DNA directed) kappa, Quinine 3-monooxygenase, RAD 30B, RAD30, RAD30 homolog A, RAD30 homolog B, RAD30, S. cerevisiae, homolog of, RAD30A, RAD3OB, RNESTROR, RP11-523H24.1, RP3 369A17.3, RXR alpha1, RXRA_HUMAN, Retinoic acid receptor RXR-alpha, Retinoid X nuclear receptor alpha, Retinoid X receptor alpha, S-mephenytoin 4-hydroxylase, Taurochenodeoxycholate 6-alpha-hydroxylase, Twa3, Two hybrid-associated protein 3 with RanBPM, WALp4, XP V, Xenobiotic monooxygenase, Xeroderma pigmentosum variant type protein, chromobox homolog 1, cytochrome P-450 S-mephenytoin 4-hydroxylase, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4, dopamine receptor D1, flavoprotein-linked monooxygenase, glucocorticoid nuclear receptor variant 1, hPPAR, hWALp4, heterochromatin protein p25 beta, nr3c1, nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor), p25beta, polymerase DNA directed eta, polymerase, DNA, kappa
- Chemical Structure
Lab
Chemical Structure - GW7647, PPARalpha agonist (AB141124)
2D chemical structure image of ab141124, GW7647, PPARalpha agonist
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
These proteins undertake several functional roles in specific cell types and contexts. The Glucocorticoid Receptor and Estrogen Receptor as nuclear hormone receptors form complexes with co-activators or co-repressors to regulate transcription. DNA Polymerases iota Kappa and eta are important for bypassing DNA lesions during replication contributing to DNA damage tolerance. PPAR alpha and PPAR gamma 2 through their action as transcription factors regulate genes associated with fatty acid oxidation and adipogenesis. Cytochrome P450 3A4 through its enzymatic capacity metabolizes xenobiotics and endogenous substrates. Proteins such as CBX1 and BAZ2B are involved in chromatin remodeling influencing gene expression profiles while the Retinoid X Receptor alpha serves as a partner for many nuclear receptors broadening their regulatory capacity.
Pathways
The involvement of these proteins in different biological processes is vast. The Glucocorticoid Receptor and Estrogen Receptor play essential roles in the steroid hormone signaling pathways affecting development metabolism and immune responses. DNA Polymerases including iota Kappa and eta play a part in the DNA repair pathways like translesion synthesis closely associated with maintaining genomic stability. PPAR alpha and gamma 2 activate pathways governing lipid metabolism impacting insulin signaling and energy homeostasis. CYP3A4 is an important player in the drug metabolism pathway impacting the efficacy and clearance of therapeutics. Additionally the Dopamine Receptor D1 is active in dopaminergic pathways that influence many neurological processes.
Publications (1)
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Scientific reports 6:32529 PubMed27581068
2016
Applications
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Species
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