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MW 329.8 Da, Purity >99%. Selective non-competitive AMPA receptor antagonist (IC50 values are 10-20, approx. 450 and >50 μM for AMPA- , kainate- and NMDA-induced responses, respectively). Skeletal muscle relaxant, orally active anticonvulsant, neuroprotective and anxiolytic in vivo.
Also available in simple stock solutions (ab146716) - add 1 ml of water to get an exact, ready-to-use concentration.
Alternative names=AMPA 1, AMPA-selective glutamate receptor 1, D(2) dopamine receptor, D2 dopamine receptor, D2DR, D2R, DRD2_HUMAN, Dopamine D2 receptor, Dopamine receptor D2, GLUH1, GRIA1_HUMAN, GluA1, GluR-1, GluR-A, GluR-K1, Glutamate receptor 1, Glutamate receptor ionotropic, Glutamate receptor ionotropic AMPA 1, HBGR1, MGC133252, OTTHUMP00000160643, OTTHUMP00000165781, OTTHUMP00000224241, OTTHUMP00000224242, OTTHUMP00000224243
- CAS number
192065-56-8
- Purity
> 99%
- Form
Solid
- Molecular weight
329.8 Da
- Molecular formula
C17H16ClN3O2
- PubChem identifier
10042240
- Nature
Synthetic
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MW 329.8 Da, Purity >99%. Selective non-competitive AMPA receptor antagonist (IC50 values are 10-20, approx. 450 and >50 μM for AMPA- , kainate- and NMDA-induced responses, respectively). Skeletal muscle relaxant, orally active anticonvulsant, neuroprotective and anxiolytic in vivo.
Also available in simple stock solutions (ab146716) - add 1 ml of water to get an exact, ready-to-use concentration.
Alternative names=AMPA 1, AMPA-selective glutamate receptor 1, D(2) dopamine receptor, D2 dopamine receptor, D2DR, D2R, DRD2_HUMAN, Dopamine D2 receptor, Dopamine receptor D2, GLUH1, GRIA1_HUMAN, GluA1, GluR-1, GluR-A, GluR-K1, Glutamate receptor 1, Glutamate receptor ionotropic, Glutamate receptor ionotropic AMPA 1, HBGR1, MGC133252, OTTHUMP00000160643, OTTHUMP00000165781, OTTHUMP00000224241, OTTHUMP00000224242, OTTHUMP00000224243
Key facts
- CAS number
192065-56-8
- Purity
> 99%
- Form
Solid
- Molecular weight
329.8 Da
- Molecular formula
C17H16ClN3O2
- PubChem identifier
10042240
- Nature
Synthetic
- Biochemical name
GYKI 52466 hydrochloride
- Biological description
Selective non-competitive AMPA receptor antagonist (IC50 values are 10-20, approx. 450 and >50 μM for AMPA- , kainate- and NMDA-induced responses, respectively). Skeletal muscle relaxant, orally active anticonvulsant, neuroprotective and anxiolytic in vivo.
Also available in simple stock solutions (ab146716) - add 1 ml of water to get an exact, ready-to-use concentration.- Canonical SMILES
CC1=NN=C(C2=CC3=C(C=C2C1)OCO3)C4=CC=C(C=C4)N.Cl
- InChI
InChI=1S/C17H15N3O2.ClH/c1-10-6-12-7-15-16(22-9-21-15)8-14(12)17(20-19-10)11-2-4-13(18)5-3-11;/h2-5,7-8H,6,9,18H2,1H3;1H
- InChIKey
RUBSCPARMVJNKX-UHFFFAOYSA-N
- IUPAC name
4-(8-methyl-9H-[1,3]dioxolo[4,5-h][2,3]benzodiazepin-5-yl)aniline;hydrochloride
Storage
- Shipped at conditions
Ambient - Can Ship with Ice
- Appropriate long-term storage conditions
Ambient
- Storage information
Store under desiccating conditions, The product can be stored for up to 12 months
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