MW 376.5 Da, Purity >95%. Water-soluble, slow-releasing hydrogen sulfide donor. Inhibits LPS-induced release of proinflammatory intermediates and increases synthesis of IL-10. Exhibits novel anti-cancer effects. Vasodilator and antihypertensive activity. Active *in vitro* and *in vivo*.
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- Journal of cellular and molecular medicine 25:3460-34682021H S catalysed by CBS regulates testosterone synthesis through affecting the sulfhydrylation of PDE.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJing Wang,Jing Wang,Tao Shen,Renyun Hong,Shanshan Tang,Xia ZhaoPubMed 33713531
- Molecular medicine reports 21:1633-16392020Protective effect of GYY4137, a water‑soluble hydrogen sulfide‑releasing molecule, on intestinal ischemia‑reperfusion.Applications:Unspecified applicationReactive species:Unspecified reactive speciesNing Cui,Hesheng Luo,Yu ZhaoPubMed 32016475
- Biochimica et biophysica acta. Molecular basis of 1864:3281-32912018Cystathionine beta synthase-hydrogen sulfide system in paraventricular nucleus reduced high fatty diet induced obesity and insulin resistance by brain-adipose axis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesFengjiao Zheng et. al.PubMed 30010047
Key facts
- CAS number
- 106740-09-4
- Purity
- > 95%
- Form
- Solid
- Molecular weight
- 376.5 Da
- Molecular formula
- C15H25N2O3PS2
- PubChem identifier
- 53393943
- Nature
- Synthetic
Target data
Recommended products
MW 376.5 Da, Purity >95%. Water-soluble, slow-releasing hydrogen sulfide donor. Inhibits LPS-induced release of proinflammatory intermediates and increases synthesis of IL-10. Exhibits novel anti-cancer effects. Vasodilator and antihypertensive activity. Active *in vitro* and *in vivo*.
Key facts
- CAS number
- 106740-09-4
- Purity
- > 95%
- Form
- Solid
- Molecular weight
- 376.5 Da
- Molecular formula
- C15H25N2O3PS2
- PubChem identifier
- 53393943
- Nature
- Synthetic
- Solubility
Soluble in water to 75 mM.
Soluble in DMSO to 25 mM.
- Biochemical name
- Morpholin-4-ium (4-methoxyphenyl)morpholin-4-ylphosphinodithioate
- Biological description
Water-soluble, slow-releasing hydrogen sulfide donor. Inhibits LPS-induced release of proinflammatory intermediates and increases synthesis of IL-10. Exhibits novel anti-cancer effects. Vasodilator and antihypertensive activity. Active *in vitro* and *in vivo*
- Canonical SMILES
- COC1=CC=C(C=C1)P(=S)(N2CCOCC2)[S-].C1COCC[NH2+]1
- InChI
- InChI=1S/C11H16NO2PS2.C4H9NO/c1-13-10-2-4-11(5-3-10)15(16,17)12-6-8-14-9-7-12;1-3-6-4-2-5-1/h2-5H,6-9H2,1H3,(H,16,17);5H,1-4H2
- InChIKey
- YZMHNNLDUWRZFW-UHFFFAOYSA-N
- IUPAC name
- (4-methoxyphenyl)-morpholin-4-yl-sulfanylidene-sulfido-λ5-phosphane;morpholin-4-ium
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
Notes
This product is manufactured by BioVision, an Abcam company and was previously called 1908 GYY 4137. 1908-25 is the same size as the 25 mg size of ab142145.
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1 product image
Chemical Structure - GYY 4137, H2S donor (ab142145)
2D chemical structure image of ab142145, GYY 4137, H2S donor
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