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AB142145

GYY 4137, H2S donor

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(4 Publications)

MW 376.5 Da, Purity >95%. Water-soluble, slow-releasing hydrogen sulfide donor. Inhibits LPS-induced release of proinflammatory intermediates and increases synthesis of IL-10. Exhibits novel anti-cancer effects. Vasodilator and antihypertensive activity. Active *in vitro* and *in vivo*.
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Chemical Structure - GYY 4137, H2S donor (AB142145)
  • Chemical Structure

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Chemical Structure - GYY 4137, H2S donor (AB142145)

2D chemical structure image of ab142145, GYY 4137, H2S donor

Key facts

CAS number

106740-09-4

Purity

>95%

Form

Solid

form

Molecular weight

376.5 Da

Molecular formula

C<sub>1</sub><sub>5</sub>H<sub>2</sub><sub>5</sub>N<sub>2</sub>O<sub>3</sub>PS<sub>2</sub>

PubChem

53393943

Nature

Synthetic

Solubility

Soluble in water to 75 mM

Soluble in DMSO to 25 mM

Biochemical name

Morpholin-4-ium (4-methoxyphenyl)morpholin-4-ylphosphinodithioate

Biological description

Water-soluble, slow-releasing hydrogen sulfide donor. Inhibits LPS-induced release of proinflammatory intermediates and increases synthesis of IL-10. Exhibits novel anti-cancer effects. Vasodilator and antihypertensive activity. Active *in vitro* and *in vivo*

Canonical smiles

COC1=CC=C(C=C1)P(=S)(N2CCOCC2)[S-].C1COCC[NH2+]1

InChi

InChI=1S/C11H16NO2PS2.C4H9NO/c1-13-10-2-4-11(5-3-10)15(16,17)12-6-8-14-9-7-12;1-3-6-4-2-5-1/h2-5H,6-9H2,1H3,(H,16,17);5H,1-4H2

InChiKey

YZMHNNLDUWRZFW-UHFFFAOYSA-N

IUPAC Name

(4-methoxyphenyl)-morpholin-4-yl-sulfanylidene-sulfido-λ5-phosphane;morpholin-4-ium

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Product details

This product is manufactured by BioVision, an Abcam company and was previously called 1908 GYY 4137. 1908-25 is the same size as the 25 mg size of ab142145.
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Cell reports 42:113560 PubMed38100351

2023

Reprogramming of tumor-associated macrophages via NEDD4-mediated CSF1R degradation by targeting USP18.

Applications

Unspecified application

Species

Unspecified reactive species

Sayuri Miyauchi,Kei-Ichiro Arimoto,Mengdan Liu,Yue Zhang,Dong-Er Zhang

Journal of cellular and molecular medicine 25:3460-3468 PubMed33713531

2021

H S catalysed by CBS regulates testosterone synthesis through affecting the sulfhydrylation of PDE.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Wang,Jing Wang,Tao Shen,Renyun Hong,Shanshan Tang,Xia Zhao

Molecular medicine reports 21:1633-1639 PubMed32016475

2020

Protective effect of GYY4137, a water‑soluble hydrogen sulfide‑releasing molecule, on intestinal ischemia‑reperfusion.

Applications

Unspecified application

Species

Unspecified reactive species

Ning Cui,Hesheng Luo,Yu Zhao

Biochimica et biophysica acta. Molecular basis of 1864:3281-3291 PubMed30010047

2018

Cystathionine beta synthase-hydrogen sulfide system in paraventricular nucleus reduced high fatty diet induced obesity and insulin resistance by brain-adipose axis.

Applications

Unspecified application

Species

Unspecified reactive species

Fengjiao Zheng,Jingnan Han,Haocheng Lu,Changting Cui,Jichun Yang,Qinghua Cui,Jun Cai,Yong Zhou,Chaoshu Tang,Guoheng Xu,Bin Geng
View all publications
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