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AB146700

HA-1077 (Fasudil) (mM/ml), ROCK2 inhibitor

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MW 327.8 Da, Purity >98%. ROCK2 inhibitor (IC50 = 1.9 μM). Also shown to inhibit PRK2 (IC50 = 4 μM), MSK1 (IC50 = 5 μM), Rsk2 (IC50 = 15 μM), PKA, p70 S6 Kinase, CaM Kinase and MLCK. Calcium antagonist and vasodilator.

Key facts

CAS number

105628-07-7

Purity

>98%

Form

Solid

form

Molecular weight

327.8 Da

Molecular formula

C<sub>1</sub><sub>4</sub>H<sub>1</sub><sub>8</sub>ClN<sub>3</sub>O<sub>2</sub>S

PubChem

163751

Nature

Synthetic

Biochemical name

Fasudil hydrochloride

Biological description

ROCK2 inhibitor (IC50 = 1.9 μM). Also shown to inhibit PRK2 (IC50 = 4 μM), MSK1 (IC50 = 5 μM), Rsk2 (IC50 = 15 μM), PKA, p70 S6 Kinase, CaM Kinase and MLCK. Calcium antagonist and vasodilator.

Canonical smiles

C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3.Cl

InChi

InChI=1S/C14H17N3O2S.ClH/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14;/h1,3-5,7,11,15H,2,6,8-10H2;1H

InChiKey

LFVPBERIVUNMGV-UHFFFAOYSA-N

IUPAC Name

5-(1,4-diazepan-1-ylsulfonyl)isoquinoline;hydrochloride

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
The product can be stored for up to 12 months
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Product protocols

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