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AB145524

HA 1100 hydrochloride (Hydroxyfasudil), Rho-kinase inhibitor

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(1 Publication)

MW 343.8 Da, Purity >99%. Selective, ATP-competitive, reversible Rho-kinase inhibitor (IC50 values are 0.6 and 0.8 μM for Rock-1 and Rock-2, respectively). Cell-permeable active Fasudil (ab120306) metabolite. Inhibits neutrophil migration and shows potent vasodilatory effects in vivo. .
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Chemical Structure - HA 1100 hydrochloride (Hydroxyfasudil), Rho-kinase inhibitor (AB145524)
  • Chemical Structure

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Chemical Structure - HA 1100 hydrochloride (Hydroxyfasudil), Rho-kinase inhibitor (AB145524)

2D chemical structure image of ab145524, HA 1100 hydrochloride (Hydroxyfasudil), Rho-kinase inhibitor

Key facts

CAS number

155558-32-0

Purity

>99%

Form

Solid

form

Molecular weight

343.8 Da

Molecular formula

C<sub>1</sub><sub>4</sub>H<sub>1</sub><sub>8</sub>ClN<sub>3</sub>O<sub>3</sub>S

PubChem

11371328

Nature

Synthetic

Solubility

Soluble in water to 25 mM

Biochemical name

Hydroxyfasudil Hydrochloride

Biological description

Selective, ATP-competitive, reversible Rho-kinase inhibitor (IC50 values are 0.6 and 0.8 μM for Rock-1 and Rock-2, respectively). Cell-permeable active Fasudil (ab120306) metabolite. Inhibits neutrophil migration and shows potent vasodilatory effects in vivo.

Canonical smiles

C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CNC3=O.Cl

InChi

InChI=1S/C14H17N3O3S.ClH/c18-14-12-3-1-4-13(11(12)5-7-16-14)21(19,20)17-9-2-6-15-8-10-17;/h1,3-5,7,15H,2,6,8-10H2,(H,16,18);1H

InChiKey

XWWFOUVDVJGNNG-UHFFFAOYSA-N

IUPAC Name

5-(1,4-diazepan-1-ylsulfonyl)-2H-isoquinolin-1-one;hydrochloride

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (1)

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Molecular and cellular biochemistry 476:2159-2170 PubMed33548010

2021

Rho-kinase inhibitor hydroxyfasudil protects against HIV-1 Tat-induced dysfunction of tight junction and neprilysin/Aβ transfer receptor expression in mouse brain microvessels.

Applications

Unspecified application

Species

Unspecified reactive species

Qiangtang Chen,Yu Wu,Yachun Yu,Junxiang Wei,Wen Huang
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