JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB141306

HA14-1, Bcl-2 inhibitor. BH-3 mimetic.

Be the first to review this product! Submit a review

|

(0 Publication)

MW 409.2 Da. Cell permeable Bcl-2 inhibitor. BH-3 mimetic. Disrupts Bax and Bcl-2 interactions. Apoptotic anticancer agent.

View Alternative Names

1 25 dihydroxyvitamin D3 receptor, 25-dihydroxyvitamin D3 receptor, AHDC, ALDC, ALDH 1, ALDH 11, ALDH class 1, ALDH class 2, ALDH-E1, ALDH-E2, ALDHI, ALDM, ALHDII, Acetaldehyde dehydrogenase 1, Acetaldehyde dehydrogenase 2, Aldehyde dehydrogenase 1, Aldehyde dehydrogenase 1 family member A1, Aldehyde dehydrogenase 1 soluble, Aldehyde dehydrogenase 1A1, Aldehyde dehydrogenase 2 family, Aldehyde dehydrogenase 2 family (mitochondrial), Aldehyde dehydrogenase cytosolic, Aldehyde dehydrogenase liver cytosolic, Aldehyde dehydrogenase mitochondrial, Aldh, Liver mitochondrial ALDH, MGC1806, MGC2318, Member 1, Mitochondrial aldehyde dehydrogenase 2, NR1I1, Nuclear receptor subfamily 1 group I member 1, Nucleus encoded mitochondrial aldehyde dehydrogenase 2, PPP1R163, PUMB 1, Protein phosphatase 1, regulatory subunit 163, RALDH 1, Retinal dehydrogenase 1, Retinaldehyde dehydrogenase 1, VDR_HUMAN, Vitamin D (1,25- dihydroxyvitamin D3) receptor, Vitamin D hormone receptor, Vitamin D nuclear receptor variant 1, Vitamin D receptor, Vitamin D3 receptor

1 Images
Chemical Structure - HA14-1, Bcl-2 inhibitor. BH-3 mimetic. (AB141306)
  • Chemical Structure

Lab

Chemical Structure - HA14-1, Bcl-2 inhibitor. BH-3 mimetic. (AB141306)

2D chemical structure image of ab141306, HA14-1, Bcl-2 inhibitor. BH-3 mimetic.

Key facts

CAS number

65673-63-4

Form

Solid

form

Molecular weight

409.2 Da

Molecular formula

C<sub>1</sub><sub>7</sub>H<sub>1</sub><sub>7</sub>BrN<sub>2</sub>O<sub>5</sub>

PubChem

3549

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Soluble in ethanol to 100 mM

Biochemical name

Ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate

Biological description

Cell permeable Bcl-2 inhibitor. BH-3 mimetic. Disrupts Bax and Bcl-2 interactions. Apoptotic anticancer agent.

Canonical smiles

CCOC(=O)C1=C(OC2=C(C1C(C#N)C(=O)OCC)C=C(C=C2)Br)N

InChi

InChI=1S/C17H17BrN2O5/c1-3-23-16(21)11(8-19)13-10-7-9(18)5-6-12(10)25-15(20)14(13)17(22)24-4-2/h5-7,11,13H,3-4,20H2,1-2H3

InChiKey

SXJDCULZDFWMJC-UHFFFAOYSA-N

IUPAC Name

ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months

Product protocols

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com