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AB120080

Haloperidol, D2 antagonist

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(1 Publication)

MW 375.9 Da, Purity >99%. Dopamine antagonist with selectivity for D2-like receptors (Ki values are 1.2 (D2), 7 (D3), 2.3 (D4), 80 (D1) and 100 nM (D5)). Also NMDA antagonist.
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Chemical Structure - Haloperidol, D2 antagonist (AB120080)
  • Chemical Structure

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Chemical Structure - Haloperidol, D2 antagonist (AB120080)

2D chemical structure image of ab120080, Haloperidol, D2 antagonist

Key facts

CAS number

52-86-8

Purity

>99%

Form

Solid

form

Molecular weight

375.9 Da

Molecular formula

C<sub>2</sub><sub>1</sub>H<sub>2</sub><sub>3</sub>ClFNO<sub>2</sub>

PubChem

3559

Nature

Synthetic

Solubility

Soluble in DMSO to 25 mM

Soluble in ethanol to 5 mM

Biochemical name

Haloperidol

Biological description

Dopamine antagonist with selectivity for D2-like receptors (Ki values are 1.2 (D2), 7 (D3), 2.3 (D4), 80 (D1) and 100 nM (D5)). Also NMDA antagonist.

Canonical smiles

C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCC(=O)C3=CC=C(C=C3)F

InChi

InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2

InChiKey

LNEPOXFFQSENCJ-UHFFFAOYSA-N

IUPAC Name

4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one

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Complementary Products

Biochemicals

AB120021

Thioperamide maleate, H3 antagonist

Chemical Structure - Thioperamide maleate, H3 antagonist (AB120021)

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Biochemicals

AB120563

(S)-(-)-Raclopride, D2 receptor antagonist

Chemical Structure - (S)-(-)-Raclopride, D2 receptor antagonist (AB120563)

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Biochemicals

AB120764

Aripiprazole, Partial dopamine D2 agonist

Chemical Structure - Aripiprazole, Partial dopamine D2 agonist (AB120764)

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Biochemicals

AB120613

Flupenthixol dihydrochloride, Non-selective dopamine receptor antagonist

Chemical Structure - Flupenthixol dihydrochloride, Non-selective dopamine receptor antagonist (AB120613)

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

The Journal of neuroscience : the official journal of the Society for Neuroscience 33:4424-33 PubMed23467359

2013

Plasticity of hypothalamic dopamine neurons during lactation results in dissociation of electrical activity and release.

Applications

Unspecified application

Species

Unspecified reactive species

Nicola Romanò,Siew H Yip,David J Hodson,Anne Guillou,Sébastien Parnaudeau,Siobhan Kirk,François Tronche,Xavier Bonnefont,Paul Le Tissier,Stephen J Bunn,Dave R Grattan,Patrice Mollard,Agnès O Martin
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