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MW 182.22 g/mol, Purity >99%. Nanomolar affinity for the I1-imidazoline receptor (IC50 = 30 nM). Endogenous to the brain. Able to cross the blood-brain barrier. Active at I1, I2 and I3 binding sites, 1000-fold selectivity for I1 over α2 adrenoceptors. Known MAO-A inhibitor.

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Images

Chemical Structure - Harmane, beta-Carboline. Imidazoline ligand. MAO inhibitor. (AB120605), expandable thumbnail

Key facts

CAS number
486-84-0
Purity
> 99%
Form
Solid
Molecular weight
182.22 g/mol
Molecular formula
C12H10N2
Nature
Synthetic

Target data

Recommended products

MW 182.22 g/mol, Purity >99%. Nanomolar affinity for the I1-imidazoline receptor (IC50 = 30 nM). Endogenous to the brain. Able to cross the blood-brain barrier. Active at I1, I2 and I3 binding sites, 1000-fold selectivity for I1 over α2 adrenoceptors. Known MAO-A inhibitor.

Key facts

Purity
> 99%
Solubility

Soluble in ethanol to 100 mM.

Soluble in DMSO to 100 mM.

Biological description

Nanomolar affinity for the I1-imidazoline receptor (IC50 = 30 nM). Endogenous to the brain. Able to cross the blood-brain barrier. Active at I1, I2 and I3 binding sites, 1000-fold selectivity for I1 over α2 adrenoceptors. Known MAO-A inhibitor.

IUPAC name
1-Methyl-9H-pyrido[3,4-b]indole

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
The product can be stored for up to 12 months

Product promise

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1 product image

  • Chemical Structure - Harmane, beta-Carboline. Imidazoline ligand. MAO inhibitor. (ab120605), expandable thumbnail

    Chemical Structure - Harmane, beta-Carboline. Imidazoline ligand. MAO inhibitor. (ab120605)

    2D chemical structure image of ab120605, Harmane, beta-Carboline. Imidazoline ligand. MAO inhibitor.

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Product protocols

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