MW 182.22 g/mol, Purity >99%. Nanomolar affinity for the I1-imidazoline receptor (IC50 = 30 nM). Endogenous to the brain. Able to cross the blood-brain barrier. Active at I1, I2 and I3 binding sites, 1000-fold selectivity for I1 over α2 adrenoceptors. Known MAO-A inhibitor.
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- Pharmacology, biochemistry, and behavior 98:215-92011Effects of harmane and other β-carbolines on apomorphine-induced licking behavior in rat.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDavood Farzin et. al.PubMed 21237191
- Neuropharmacology 50:269-762005In vitro and ex vivo distribution of [3H]harmane, an endogenous beta-carboline, in rat brain.Applications:Unspecified applicationReactive species:Unspecified reactive speciesNeil J Anderson,Robin J Tyacke,Stephen M Husbands,David J Nutt,Alan L Hudson,Emma S J RobinsonPubMed 16242163
- British journal of pharmacology 129:1057-92000Harmane produces hypotension following microinjection into the RVLM: possible role of I(1)-imidazoline receptors.Applications:Unspecified applicationReactive species:Unspecified reactive speciesI F Musgrave,E BadoerPubMed 10725251
Key facts
- CAS number
486-84-0
- Purity
> 99%
- Form
Solid
- Molecular weight
182.22 g/mol
- Molecular formula
C12H10N2
- Nature
Synthetic
Recommended products
MW 182.22 g/mol, Purity >99%. Nanomolar affinity for the I1-imidazoline receptor (IC50 = 30 nM). Endogenous to the brain. Able to cross the blood-brain barrier. Active at I1, I2 and I3 binding sites, 1000-fold selectivity for I1 over α2 adrenoceptors. Known MAO-A inhibitor.
Key facts
- CAS number
486-84-0
- Purity
> 99%
- Form
Solid
- Molecular weight
182.22 g/mol
- Molecular formula
C12H10N2
- Nature
Synthetic
- Solubility
Soluble in ethanol to 100 mM. Soluble in DMSO to 100 mM.
- Biological description
Nanomolar affinity for the I1-imidazoline receptor (IC50 = 30 nM). Endogenous to the brain. Able to cross the blood-brain barrier. Active at I1, I2 and I3 binding sites, 1000-fold selectivity for I1 over α2 adrenoceptors. Known MAO-A inhibitor.
- IUPAC name
1-Methyl-9H-pyrido[3,4-b]indole
Storage
- Shipped at conditions
Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
Ambient
- Appropriate long-term storage conditions
Ambient
- Storage information
The product can be stored for up to 12 months
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1 product image
Chemical Structure - Harmane, beta-Carboline. Imidazoline ligand. MAO inhibitor. (ab120605)
2D chemical structure image of ab120605, Harmane, beta-Carboline. Imidazoline ligand. MAO inhibitor.
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