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MW 212.25 Da, Purity >98%. Potent and selective inhibitor of DYRK1A (dual specificity tyrosine-phosphorylated and -regulated kinase). (IC50 values are 0.08 (DYRK1A), 0.9 (DYRK2), 0.8 (DYRK3), 4.3 (PIM3) and 1.5 μM (CK1)). 5-HT antagonist and MAO inhibitor. Regulator of PPARγ expression and antidiabetic.

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Chemical Structure - Harmine, DYRK1A inhibitor (AB120225), expandable thumbnail

Publications

Key facts

CAS number
442-51-3
Purity
> 98%
Form
Solid
Molecular weight
212.25 Da
Molecular formula
C13H12N2O
PubChem identifier
5280953
Nature
Synthetic

Alternative names

Recommended products

MW 212.25 Da, Purity >98%. Potent and selective inhibitor of DYRK1A (dual specificity tyrosine-phosphorylated and -regulated kinase). (IC50 values are 0.08 (DYRK1A), 0.9 (DYRK2), 0.8 (DYRK3), 4.3 (PIM3) and 1.5 μM (CK1)). 5-HT antagonist and MAO inhibitor. Regulator of PPARγ expression and antidiabetic.

Key facts

Purity
> 98%
PubChem identifier
5280953
Solubility

Soluble in DMSO to 100 mM.

Biochemical name
Harmine
Biological description

Potent and selective inhibitor of DYRK1A (dual specificity tyrosine-phosphorylated and -regulated kinase). (IC50 values are 0.08 (DYRK1A), 0.9 (DYRK2), 0.8 (DYRK3), 4.3 (PIM3) and 1.5 μM (CK1)). 5-HT antagonist and MAO inhibitor. Regulator of PPARγ expression and antidiabetic.

Canonical SMILES
CC1=NC=CC2=C1NC3=C2C=CC(=C3)OC
InChI
InChI=1S/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H3
InChIKey
BXNJHAXVSOCGBA-UHFFFAOYSA-N
IUPAC name
7-methoxy-1-methyl-9H-pyrido[3,4-b]indole

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
The product can be stored for up to 12 months

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1 product image

  • Chemical Structure - Harmine, DYRK1A inhibitor (ab120225), expandable thumbnail

    Chemical Structure - Harmine, DYRK1A inhibitor (ab120225)

    2D chemical structure image of ab120225, Harmine, DYRK1A inhibitor

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Product protocols

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