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MW 355.4 Da, Purity >99%. Selective TRPA1 blocker, orally active. Blocks TRPA1-mediated currents (IC50 = 0.7 μM) and selective over TRPV1, TRPV3, TRPV4, hERG, and NaV1.2 channels (IC50 >10 μM). Does not display any significant binding to 41 other receptors, ion channels, and transporters nor functional modulation of 7 enzymes that are known to modulate pain signaling.
Alternative names=ANKTM 1, Ankyrin-like with transmembrane domains protein 1, TRPA1_HUMAN, Transformation-sensitive protein p120, Transient receptor potential cation channel subfamily A member 1
- CAS number
349085-38-7
- Purity
> 99%
- Form
Solid
- Molecular weight
355.4 Da
- Molecular formula
C18H21N5O3
- PubChem identifier
1150897
- Nature
Synthetic
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MW 355.4 Da, Purity >99%. Selective TRPA1 blocker, orally active. Blocks TRPA1-mediated currents (IC50 = 0.7 μM) and selective over TRPV1, TRPV3, TRPV4, hERG, and NaV1.2 channels (IC50 >10 μM). Does not display any significant binding to 41 other receptors, ion channels, and transporters nor functional modulation of 7 enzymes that are known to modulate pain signaling.
Alternative names=ANKTM 1, Ankyrin-like with transmembrane domains protein 1, TRPA1_HUMAN, Transformation-sensitive protein p120, Transient receptor potential cation channel subfamily A member 1
Key facts
- CAS number
349085-38-7
- Purity
> 99%
- Form
Solid
- Molecular weight
355.4 Da
- Molecular formula
C18H21N5O3
- PubChem identifier
1150897
- Nature
Synthetic
- Biochemical name
2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide
- Biological description
Selective TRPA1 blocker, orally active. Blocks TRPA1-mediated currents (IC50 = 0.7 μM) and selective over TRPV1, TRPV3, TRPV4, hERG, and NaV1.2 channels (IC50 >10 μM). Does not display any significant binding to 41 other receptors, ion channels, and transporters nor functional modulation of 7 enzymes that are known to modulate pain signaling.
- Canonical SMILES
CC(C)C1=CC=C(C=C1)NC(=O)CN2C=NC3=C2C(=O)N(C(=O)N3C)C
- InChI
InChI=1S/C18H21N5O3/c1-11(2)12-5-7-13(8-6-12)20-14(24)9-23-10-19-16-15(23)17(25)22(4)18(26)21(16)3/h5-8,10-11H,9H2,1-4H3,(H,20,24)
- InChIKey
HEQDZPHDVAOBLN-UHFFFAOYSA-N
- IUPAC name
2-(1,3-dimethyl-2,6-dioxopurin-7-yl)-N-(4-propan-2-ylphenyl)acetamide
Storage
- Shipped at conditions
Ambient - Can Ship with Ice
- Appropriate long-term storage conditions
Ambient
- Storage information
The product can be stored for up to 12 months
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