Helenalin, NF-kappaB inhibitor
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(5 Publications)
MW 262.3 Da. NF-κB inhibitor. Induces apoptosis. Shows anti-inflammatory and antineoplastic effects. Shows hepatoprotective effects in vivo. Orally active. .
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ABC 35, ABCC 7, ACTFS, ATAD5_HUMAN, ATP Binding Cassette Superfamily C Member 7, ATP binding cassette transporter sub family C member 7, ATP-binding cassette sub-family C member 7, ATPase family AAA domain containing 5, ATPase family AAA domain-containing protein 5, C17orf41, CF, CFTR/MRP, CFTR_HUMAN, Channel conductance-controlling ATPase, Chromosome fragility-associated gene 1 protein, Cystic Fibrosis Transmembrane Regulator, Cystic fibrosis transmembrane conductance regulator, Cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub family C, member 7), Cystic fibrosis transmembrane conductance regulator ATP binding cassette sub family C member 7, Cytosolic NADP-isocitrate dehydrogenase, DNA replication inhibitor, Double minute 2 protein, E3 ubiquitin-protein ligase Mdm2, ELG1, ESCS, Enhanced level of genomic instability 1 homolog, Epididymis luminal protein 216, Epididymis secretory protein Li 26, FRAG1, GEMI_HUMAN, GMNN, Geminin, Geminin DNA replication inhibitor, HDMX, HEL-216, HEL-S-26, Hdm 2, ICDH, IDCD, IDH, IDH1, IDHC_HUMAN, IDP, IDPC, Isocitrate dehydrogenase (NADP(+)) 1 cytosolic, Isocitrate dehydrogenase 1 (NADP+) soluble, Isocitrate dehydrogenase [NADP] cytoplasmic, MDM2 oncogene E3 ubiquitin protein ligase, MDM2BP, MDM2_HUMAN, MGC49976, Mdm2 p53 E3 ubiquitin protein ligase homolog, Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse) binding protein 104kDa, Mouse Double Minute 2, Murine Double Minute Chromosome 2, NADP dependent isocitrate dehydrogenase cytosolic, NADP dependent isocitrate dehydrogenase peroxisomal, NADP(+)-specific ICDH, NR2E3_HUMAN, Nuclear receptor subfamily 2 group E member 3, OTTHUMP00000039393, Oncoprotein Mdm2, Oxalosuccinate decarboxylase, PICD, Photoreceptor-specific nuclear receptor, RNR, RP3 369A17.3, RP37, Rd 7, Retina-specific nuclear receptor, Retinal degeneration 7, TNR CFTR, Ubiquitin protein ligase E3 Mdm2, cAMP-dependent chloride channel, chromosome fragility associated gene 1, dJ760C5.1, p53-binding protein Mdm2
- Chemical Structure
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Chemical Structure - Helenalin, NF-kappaB inhibitor (AB146197)
2D chemical structure image of ab146197, Helenalin, NF-kappaB inhibitor
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Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
CFTR regulates ion transport across epithelial membranes and maintains fluid homeostasis. It integrates into the complex and dynamic processes involving epithelial barrier function. MDM2 controls p53 levels affecting cell cycle and apoptosis. Geminin prevents DNA re-replication by inhibiting DNA replication licensing. NR2E3 modulates photoreceptor gene expression in the retina functioning with other transcription factors. IDH1 plays a critical role in the Krebs cycle facilitating energy production and biomolecular synthesis. Atad5 helps in removing blockages during DNA replication ensuring genome stability.
Pathways
CFTR is essential in the cAMP-regulated pathway impacting ion homeostasis including the ENaC pathway. It connects with protein kinases like PKA. MDM2 situates itself within the p53 signaling pathway working alongside proteins like ARF. Geminin interacts within the DNA replication licensing pathway with proteins such as Cdt1. NR2E3 is part of the phototransduction pathway linked to CRX. IDH1 functions in the citric acid cycle associated with enzymes like ACO1. Atad5 operates within the DNA damage response pathway related to PCNA.
Publications (5)
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Thoracic cancer 12:2698-2709 PubMed34423566
2021
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Scientific reports 11:14608 PubMed34272458
2021
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Scientific reports 10:216 PubMed31937805
2020
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Journal of dermatological science 93:168-175 PubMed30904352
2019
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Journal of dermatological science 91:256-267 PubMed29807809
2018
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