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AB120458

HENECA, A2A receptor agonist

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(1 Publication)

MW 388.4 Da, Purity >99%. Selective A2A receptor agonist (Ki = 2.2 nM). Shows good selectivity for A2A over A1 receptors. Displays antiaggregatory activity. Increases cAMP accumulation (EC50 = 43 nM) and inhibits superoxide anion production (EC50 = 3.63 nM) in neutrophils.
2 Images
Cellular Activation - HENECA, A2A receptor agonist (AB120458)
  • CellAct

Unknown

Cellular Activation - HENECA, A2A receptor agonist (AB120458)

Concentration-dependent effect of HENECA (10-200 nM, 24 hours) on Aβ42 production.

Image from Nagpure B V, et al. Plos One, 9(2), e88508. Fig 1a,; doi: 10.1371/journal.pone.0088508

Chemical Structure - HENECA, A2A receptor agonist (AB120458)
  • Chemical Structure

Lab

Chemical Structure - HENECA, A2A receptor agonist (AB120458)

2D chemical structure image of ab120458, HENECA, A2A receptor agonist

Key facts

CAS number

141018-30-6

Purity

>99%

Form

Solid

form

Molecular weight

388.4 Da

Molecular formula

C<sub>1</sub><sub>8</sub>H<sub>2</sub><sub>4</sub>N<sub>6</sub>O<sub>4</sub>

PubChem

4438292

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Soluble in ethanol to 50 mM (with heating)

Biochemical name

2-Hexynyl-5'-N-ethylcarboxamidoadenosine

Biological description

Selective A2A receptor agonist (Ki = 2.2 nM). Shows good selectivity for A2A over A1 receptors. Displays antiaggregatory activity. Increases cAMP accumulation (EC50 = 43 nM) and inhibits superoxide anion production (EC50 = 3.63 nM) in neutrophils.

Canonical smiles

CCCCC#CC1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)C(=O)NCC)O)O)N

InChi

InChI=1S/C18H24N6O4/c1-3-5-6-7-8-10-22-15(19)11-16(23-10)24(9-21-11)18-13(26)12(25)14(28-18)17(27)20-4-2/h9,12-14,18,25-26H,3-6H2,1-2H3,(H,20,27)(H2,19,22,23)

InChiKey

FDEACFAXFCKCHZ-UHFFFAOYSA-N

IUPAC Name

5-(6-amino-2-hex-1-ynylpurin-9-yl)-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
The product can be stored for up to 12 months
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

PloS one 9:e88508 PubMed24523906

2014

Hydrogen sulfide inhibits A2A adenosine receptor agonist induced β-amyloid production in SH-SY5Y neuroblastoma cells via a cAMP dependent pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Bhushan Vijay Nagpure,Jin-Song Bian
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