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MW 280.32 Da, Purity >95%. Potent, selective, irreversible GAPDH inhibitor. Selective, competitive DNA polymerase inhibitor. Antibiotic agent. Potently inhibits ATP generation in the glycolytic pathway. Inhibits DNA polymerases β, λ and terminal deoxynucleotidyl transferase (TdT) in family X. Inhibits caspase- 3 induction (IC50 = 40 μM). Shows antiapoptotic effects.

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Key facts

CAS number

57710-57-3

Purity

> 95%

Form

Solid

Source

Trichoderma sp.

Molecular weight

280.32 Da

Molecular formula

C15H20O5

PubChem identifier

10945834

Nature

Native

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MW 280.32 Da, Purity >95%. Potent, selective, irreversible GAPDH inhibitor. Selective, competitive DNA polymerase inhibitor. Antibiotic agent. Potently inhibits ATP generation in the glycolytic pathway. Inhibits DNA polymerases β, λ and terminal deoxynucleotidyl transferase (TdT) in family X. Inhibits caspase- 3 induction (IC50 = 40 μM). Shows antiapoptotic effects.

Key facts

Purity

> 95%

Source

Trichoderma sp.

PubChem identifier

10945834

Biochemical name

Heptelidic acid

Biological description

Potent, selective, irreversible GAPDH inhibitor. Selective, competitive DNA polymerase inhibitor. Antibiotic agent. Potently inhibits ATP generation in the glycolytic pathway. Inhibits DNA polymerases β, λ and terminal deoxynucleotidyl transferase (TdT) in family X. Inhibits caspase- 3 induction (IC50 = 40 μM). Shows antiapoptotic effects.

Canonical SMILES

CC(C)C1CCC2(CO2)C3C1C=C(COC3=O)C(=O)O

Isomeric SMILES

CC(C)[C@H]1CC[C@@]2(CO2)[C@@H]3[C@@H]1C=C(COC3=O)C(=O)O

InChI

InChI=1S/C15H20O5/c1-8(2)10-3-4-15(7-20-15)12-11(10)5-9(13(16)17)6-19-14(12)18/h5,8,10-12H,3-4,6-7H2,1-2H3,(H,16,17)/t10-,11-,12-,15-/m1/s1

InChIKey

JESMSCGUTIEROV-RTWAVKEYSA-N

IUPAC name

(5aS,6R,9S,9aS)-1-oxo-6-propan-2-ylspiro[3,5a,6,7,8,9a-hexahydro-2-benzoxepine-9,2'-oxirane]-4-carboxylic acid

Storage

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate long-term storage conditions

-20°C

Storage information

Store under desiccating conditions, The product can be stored for up to 12 months

Product promise

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In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
Terms & Conditions.

1 product image

  • Chemical Structure - Heptelidic acid (Koningic acid), GAPDH inhibitor (ab144269), expandable thumbnail

    Chemical Structure - Heptelidic acid (Koningic acid), GAPDH inhibitor (ab144269)

    2D chemical structure image of ab144269, Heptelidic acid (Koningic acid), GAPDH inhibitor

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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