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AB141262

HNHA, HDAC inhibitor

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MW 303.4 Da, Purity >98%. Potent, cell-permeable HDAC inhibitor (IC50 = 100 nM). Induces histone hyperacetylation and p21 transcription with concomitant inhibition of cell cycle progression. Arrests cell cycle at G1/S phase in cancer cells. Antitumor and antiangiogenic agent. Active in vivo and in vitro.
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Chemical Structure - HNHA, HDAC inhibitor (AB141262)
  • Chemical Structure

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Chemical Structure - HNHA, HDAC inhibitor (AB141262)

2D chemical structure image of ab141262, HNHA, HDAC inhibitor

Key facts

CAS number

926908-04-5

Purity

>98%

Form

Solid

form

Molecular weight

303.4 Da

Molecular formula

C<sub>1</sub><sub>7</sub>H<sub>2</sub><sub>1</sub>NO<sub>2</sub>S

PubChem

16126782

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biochemical name

N-hydroxy-7-(naphthalen-2-ylthio)heptanamide

Biological description

Potent, cell-permeable HDAC inhibitor (IC50 = 100 nM). Induces histone hyperacetylation and p21 transcription with concomitant inhibition of cell cycle progression. Arrests cell cycle at G1/S phase in cancer cells. Antitumor and antiangiogenic agent. Active in vivo and in vitro.

Canonical smiles

C1=CC=C2C=C(C=CC2=C1)SCCCCCCC(=O)NO

InChi

InChI=1S/C17H21NO2S/c19-17(18-20)9-3-1-2-6-12-21-16-11-10-14-7-4-5-8-15(14)13-16/h4-5,7-8,10-11,13,20H,1-3,6,9,12H2,(H,18,19)

InChiKey

KPNNXHVGOKRBEF-UHFFFAOYSA-N

IUPAC Name

N-hydroxy-7-naphthalen-2-ylsulfanylheptanamide

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
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Product protocols

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