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AB144614

HPI-1, hedgehog signaling inhibitor

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MW 463.5 Da, Purity >98%. Potent hedgehog signaling inhibitor (IC50 values are 1.5 (Shh), 1.5 (SAG), 4 (Gli2) and 6 μM (Gli1)). Antitumor agent. Active in vivo and in vitro..
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Chemical Structure - HPI-1, hedgehog signaling inhibitor (AB144614)
  • Chemical Structure

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Chemical Structure - HPI-1, hedgehog signaling inhibitor (AB144614)

2D chemical structure image of ab144614, HPI-1, hedgehog signaling inhibitor

Key facts

CAS number

599150-20-6

Purity

>98%

Form

Solid

form

Molecular weight

463.5 Da

Molecular formula

C<sub>2</sub><sub>7</sub>H<sub>2</sub><sub>9</sub>NO<sub>6</sub>

PubChem

2926768

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Soluble in ethanol to 100 mM

Biochemical name

2-Methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate

Biological description

Potent hedgehog signaling inhibitor (IC50 values are 1.5 (Shh), 1.5 (SAG), 4 (Gli2) and 6 μM (Gli1)). Antitumor agent. Active in vivo and in vitro.

Canonical smiles

CC1=C(C(C2=C(N1)CC(CC2=O)C3=CC=CC=C3OC)C4=CC(=CC=C4)O)C(=O)OCCOC

InChi

InChI=1S/C27H29NO6/c1-16-24(27(31)34-12-11-32-2)25(17-7-6-8-19(29)13-17)26-21(28-16)14-18(15-22(26)30)20-9-4-5-10-23(20)33-3/h4-10,13,18,25,28-29H,11-12,14-15H2,1-3H3

InChiKey

ZXSWZQSYZYMZKS-UHFFFAOYSA-N

IUPAC Name

2-methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-4,6,7,8-tetrahydro-1H-quinoline-3-carboxylate

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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