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AB141566

Hydroxy-2-naphthalenylmethylphosphonic acid (HNMPA), Insulin receptor tyrosine kinase inhibitor

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(2 Publications)

MW 238.18 Da, Purity >98%. Insulin receptor tyrosine kinase inhibitor (IC50 = 100 μM). Inhibits serine and tyrosine autophosphorylation by the human insulin receptor. Membrane impermeable (membrane permeable analog available ab141567).
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Chemical Structure - Hydroxy-2-naphthalenylmethylphosphonic acid (HNMPA), Insulin receptor tyrosine kinase inhibitor (AB141566)
  • Chemical Structure

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Chemical Structure - Hydroxy-2-naphthalenylmethylphosphonic acid (HNMPA), Insulin receptor tyrosine kinase inhibitor (AB141566)

2D chemical structure image of ab141566, Hydroxy-2-naphthalenylmethylphosphonic acid (HNMPA), Insulin receptor tyrosine kinase inhibitor

Key facts

CAS number

120943-99-9

Purity

>98%

Form

Solid

form

Molecular weight

238.18 Da

Molecular formula

C<sub>1</sub><sub>1</sub>H<sub>1</sub><sub>1</sub>O<sub>4</sub>P

PubChem

129317

Nature

Synthetic

Solubility

Soluble in ethanol to 100 mM

Soluble in DMSO to 100 mM

Biochemical name

(Hydroxy-2-naphthalenylmethyl)phosphonic acid

Biological description

Insulin receptor tyrosine kinase inhibitor (IC50 = 100 μM). Inhibits serine and tyrosine autophosphorylation by the human insulin receptor. Membrane impermeable (membrane permeable analog available ab141567).

Canonical smiles

C1=CC=C2C=C(C=CC2=C1)C(O)P(=O)(O)O

InChi

InChI=1S/C11H11O4P/c12-11(16(13,14)15)10-6-5-8-3-1-2-4-9(8)7-10/h1-7,11-12H,(H2,13,14,15)

InChiKey

AMJJLDJPDLKNJA-UHFFFAOYSA-N

IUPAC Name

[hydroxy(naphthalen-2-yl)methyl]phosphonic acid

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Complementary Products

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

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Biochemicals

AB141210

CYN 154806, selective somatostatin receptor 2 (sst2) antagonist

Chemical Structure - CYN 154806, selective somatostatin receptor 2 (sst2) antagonist (AB141210)

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Primary Antibodies

AB55281

Anti-SGK1 (phospho S422) antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SGK1 (phospho S422) antibody (AB55281)

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  • 2
Primary Antibodies

AB181604

Anti-HNF-4-alpha antibody [EPR16885] - ChIP Grade

RabMAb|Advanced Validation|Recombinant

Western blot - Anti-HNF-4-alpha antibody [EPR16885] - ChIP Grade (AB181604)

  • 5
  • 4
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

iScience 28:112015 PubMed40144638

2025

Signal transduction pathways controlling gene activity and beta cell state transitions.

Applications

Unspecified application

Species

Unspecified reactive species

Chieh Min Chu,Bhavya Sabbineni,Haoning Howard Cen,Xiaoke Hu,WenQing Grace Sun,George P Brownrigg,Yi Han Xia,Jason Rogalski,James D Johnson

Science advances 11:eads3718 PubMed39908379

2025

Chemical genetics reveals cross-regulation of plant developmental signaling by the immune peptide-receptor pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Arvid Herrmann,Krishna Mohan Sepuru,Pengfei Bai,Hitoshi Endo,Ayami Nakagawa,Shuhei Kusano,Asraa Ziadi,Hiroe Kato,Ayato Sato,Jun Liu,Libo Shan,Seisuke Kimura,Kenichiro Itami,Naoyuki Uchida,Shinya Hagihara,Keiko U Torii
View all publications
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