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MW 504.4 Da, Purity >97%. Selective PKC inhibitor (IC50 = 3.3 μM). Antiviral agent. Potent tyrosine kinase inhibitor (IC50 = 7.5 μM). Potent CKII inhibitor (IC50 = 6 nM). Inactivates enveloped viruses including HIV. Promotes VEGF and TGF-β production. Shows photosensitizing and antidepressant effects in vivo. .

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Images

Chemical Structure - Hypericin, PKC inhibitor (AB142440), expandable thumbnail

Publications

  • Medical science monitor basic research 20:36-462014
    Comparison of efficacy of topical phenytoin with hypericin in second-degree burn wound healing: an experimental study in rats.
    Applications:
    Unspecified application
    Reactive species:
    Unspecified reactive species
    Hamide Sayar et. al.
    PubMed 24694757
  • European archives of oto-rhino-laryngology : offic 272:711-82014
    Photosensitizing effects of hypericin on head neck squamous cell carcinoma in vitro.
    Applications:
    Unspecified application
    Reactive species:
    Unspecified reactive species
    Wiebke Laffers et. al.
    PubMed 24687800

Key facts

CAS number

548-04-9

Purity

> 97%

Form

Solid

Source

Hypericum perforatum

Molecular weight

504.4 Da

Molecular formula

C30H16O8

PubChem identifier

5281051

Nature

Native

Target data

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MW 504.4 Da, Purity >97%. Selective PKC inhibitor (IC50 = 3.3 μM). Antiviral agent. Potent tyrosine kinase inhibitor (IC50 = 7.5 μM). Potent CKII inhibitor (IC50 = 6 nM). Inactivates enveloped viruses including HIV. Promotes VEGF and TGF-β production. Shows photosensitizing and antidepressant effects in vivo. .

Key facts

Purity

> 97%

Source

Hypericum perforatum

PubChem identifier

5281051

Solubility

Soluble in DMSO to 50 mM. Soluble in ethanol to 10 mM (with warming).

Biochemical name

CID 5281051

Biological description

Selective PKC inhibitor (IC50 = 3.3 μM). Antiviral agent. Potent tyrosine kinase inhibitor (IC50 = 7.5 μM). Potent CKII inhibitor (IC50 = 6 nM). Inactivates enveloped viruses including HIV. Promotes VEGF and TGF-β production. Shows photosensitizing and antidepressant effects in vivo.

Canonical SMILES

CC1=CC(=C2C3=C4C5=C(C(=CC(=C5C2=O)O)O)C6=C7C4=C8C(=C13)C(=CC(=C8C(=O)C7=C(C=C6O)O)O)C)O

Isomeric SMILES

CC1=CC(=C2C3=C4C5=C(C(=CC(=C5C2=O)O)O)C6=C7C4=C8C(=C13)C(=CC(=C8C(=O)C7=C(C=C6O)O)O)C)O

InChI

InChI=1S/C30H16O8/c1-7-3-9(31)19-23-15(7)16-8(2)4-10(32)20-24(16)28-26-18(12(34)6-14(36)22(26)30(20)38)17-11(33)5-13(35)21(29(19)37)25(17)27(23)28/h3-6,31-36H,1-2H3

InChIKey

BTXNYTINYBABQR-UHFFFAOYSA-N

IUPAC name

5,7,11,18,22,24-hexahydroxy-13,16-dimethyloctacyclo[13.11.1.12,10.03,8.04,25.019,27.021,26.014,28]octacosa-1(27),2(28),3,5,7,10,12,14,16,18,21,23,25-tridecaene-9,20-dione

Storage

Shipped at conditions

Blue Ice

Appropriate long-term storage conditions

+4°C

Storage information

Store under desiccating conditions, The product can be stored for up to 12 months

Product promise

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Terms & Conditions.

1 product image

  • Chemical Structure - Hypericin, PKC inhibitor (ab142440), expandable thumbnail

    Chemical Structure - Hypericin, PKC inhibitor (ab142440)

    2D chemical structure image of ab142440, Hypericin, PKC inhibitor

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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