I-BET151, pan-BET family inhibitor

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MW 415.4 Da, Purity >98%. I-BET151 is an isoxazole class pan-BET family inhibitor, blocking BRD2, BRD3 and BRD4 with IC₅₀ values of 0.5, 0.25 and 0.79 μM, respectively. Specifically, I-BET151 induces apoptosis via reduced expression of BCL2 or triggers G₀/G₁ cell cycle arrest in MLL-fusion cell lines.

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(R)-limonene 6-monooxygenase, (S)-limonene 6-monooxygenase, (S)-limonene 7-monooxygenase, 1,8-cineole 2-exo-monooxygenase, 1B07_HUMAN, 5''-cyclic phosphodiesterase 4B, AS, Albendazole monooxygenase, Albendazole sulfoxidase, B-4901, B-7 alpha chain, BRD 6, BRD2_HUMAN, BRD3_HUMAN, BRD4-NUT FUSION, BRD4-NUT fusion oncoprotein, BRD4_HUMAN, BRDT protein, BRDT_HUMAN, Beta-interferon, Bromodomain containing 2, Bromodomain containing 3, Bromodomain containing 4, Bromodomain testis specific, Bromodomain testis-specific protein, Bromodomain-containing protein 2, Bromodomain-containing protein 3, Bromodomain-containing protein 4, CAP, CBP_HUMAN, CP2C9_HUMAN, CP33, CP34, CP3A4_HUMAN, CPC9, CREB-binding protein, CT9, CYP2C, CYP2C10, CYP3, CYP3A, CYP3A3, CYP3A4, CYPIIC9, CYPIIIA3, CYPIIIA4, Cancer/testis antigen 9, Cyclic AMP responsive enhancer binding protein, Cytochrome P-450MP, Cytochrome P450 2C9, Cytochrome P450 3A3, Cytochrome P450 3A4, Cytochrome P450 HLp, Cytochrome P450 MP-4, Cytochrome P450 MP-8, Cytochrome P450 NF-25, Cytochrome P450 PB-1, Cytochrome P450 family 3 subfamily A polypeptide 4, Cytochrome P450 subfamily IIIA polypeptide 4, Cytochrome P450, family 2, subfamily C, polypeptide 9, Cytochrome P450-PCN1, D6S113E, DKFZp686F2182, DKFZp686N0336, DPDE4, FLJ31942, FSH, FSRG1, Female sterile homeotic related gene 1, Female sterile homeotic related gene 1, mouse, homolog of, Fibroblast interferon, Glucocorticoid inducible P450, HC class I antigen SHCHA, HLA class I histocompatibility antigen, HLA class I histocompatibility antigen, B alpha chain, HLA-B histocompatibility type, HLP, HUNK1, HUNKI, IFB, IFF, IFN-beta, IFNB 1, IFNB_HUMAN, Interferon beta, Interferon beta 1 fibroblast, Interferon beta precursor, KAT3A, KIAA0043, KIAA9001, MCAP, MGC126529, MGC126680, MGC149605, MGC88320, MGC96956, MHC Class I HLA heavy chain, MHC HLA-B cell surface glycoprotein, MHC HLA-B transmembrane glycoprotein, MHC class 1 antigen, MHC class I antigen HLA-B alpha chain, MHC class I antigen HLA-B heavy chain, MHC class I molecule, MHC class I-antigen B*7, Microsomal monooxygenase, Mitotic chromosome-associated protein, NAT, NF 25, Nifedipine oxidase, O27.1.1, ORFX, OTTHUMP00000010652, OTTHUMP00000010653, OTTHUMP00000010654, OTTHUMP00000010656, OTTHUMP00000020135, OTTHUMP00000232365, Open reading frame X, P450 III steroid inducible, P450 MP, P450 PB 1, P450 PCN1, P450, family III, P450C3, P450IIC9, PDE IVB, PDE32, PDE4B5, PDE4B_HUMAN, Phosphodiesterase 4B, Phosphodiesterase 4B cAMP specific, Phosphodiesterase 4B, cAMP specific (phosphodiesterase E4 dunce homolog, Drosophila), Protein HUNK1, Quinine 3-monooxygenase, RING3, RING3 PROTEIN, RING3 like gene, RING3-like protein, RING3L, RNF3, RSTS, RTS, Really interesting new gene 3 protein, Rubinstein Taybi syndrome, S-mephenytoin 4-hydroxylase, SPDA1, Taurochenodeoxycholate 6-alpha-hydroxylase, Testis specific bromodomain protein, Xenobiotic monooxygenase, cAMP-specific 3'', cAMP-specific 3',5'-cyclic phosphodiesterase 4B, cAMP-specific phosphodiesterase-4 B isoform, chromosome associated protein, cytochrome P-450 S-mephenytoin 4-hydroxylase, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4, dunce-like phosphodiesterase E4, flavoprotein-linked monooxygenase, leukocyte antigen class I-B, major histocompatibility complex, class I, B