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AB120041

Ibotenic acid, excitotoxic agonist

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(13 Publications)

MW 158.11 Da, Purity >98%. Neuroexcitatory amino acid originally isolated from Amanita species. Neurotoxin often used to model cognitive dysfunctions. NMDA and metabotropic receptor agonist.

View Alternative Names

AW490526, EB11, EIEE27, EPND, FESD, GLUR, GPRC1A, GPRC1E, GRIN 2A, GRIN 2B, GRIN3A, GRIN3B, GRM1-Alpha, GRM1_HUMAN, GRM5_HUMAN, GluN1, GluN2A, GluN2C, GluN2D, Glutamate Receptor Ionotropic N Methyl D Aspartate 2B, Glutamate Receptor Ionotropic N Methyl D Aspartate 2C, Glutamate Receptor Ionotropic N Methyl D Aspartate subunit 2B, Glutamate Receptor Ionotropic N methyl D aspartate 3A, Glutamate [NMDA] receptor subunit epsilon-1, Glutamate [NMDA] receptor subunit epsilon-2, Glutamate [NMDA] receptor subunit epsilon-3, Glutamate [NMDA] receptor subunit epsilon-4, Glutamate [NMDA] receptor subunit zeta-1, Glutamate receptor, Glutamate receptor ionotropic, Glutamate receptor ionotropic N methyl D aspartate 1, Glutamate receptor ionotropic N methyl D aspartate 2A, Glutamate receptor ionotropic N methyl D aspartate 3B, Glutamate receptor ionotropic NMDA2B, Glutamate receptor ionotropic, N-methyl-D aspartate, subunit 1, Glutamate receptor ionotropic, NMDA 2C, Glutamate receptor metabotropic 1, Glutamate receptor metabotropic 5, Glutamate receptor subunit epsilon 2, Glutamate receptor, ionotropic, N-methyl D-aspartate 2D, Glutamate receptor, ionotropic, NMDA2B (epsilon 2), Grin2c, Grin2d, LKS, MGC142178, MGC142180, MGLU1, MRD6, MRD8, Metabotropic glutamate receptor 1, Metabotropic glutamate receptor 5, Metabotropic glutamate receptor 5 variant F, Metabotropic glutamate receptor 5 variant G, Metabotropic glutamate receptor 5 variant H, N Methly D Aspartate Receptor Channel Subunit Epsilon 3, N methyl D asparate receptor channel subunit epsilon 2, N methyl D aspartate receptor channel subunit zeta 1, N methyl D aspartate receptor channel, subunit epsilon 1, N methyl D aspartate receptor subunit 2A, N methyl D aspartate receptor subunit 2B, N methyl D aspartate receptor subunit 2C, N methyl d aspartate receptor subunit 2D, N-methyl D-aspartate receptor subtype 2A, N-methyl D-aspartate receptor subtype 2B, N-methyl D-aspartate receptor subtype 2C, N-methyl D-aspartate receptor subtype 2D, N-methyl-D-aspartate receptor, N-methyl-D-aspartate receptor subunit 3, N-methyl-D-aspartate receptor subunit NR1, NMD-R1, NMDA 1, NMDA 2D, NMDA NR2B, NMDA receptor 1, NMDA receptor subtype 2A, NMDA receptor subunit 3A, NMDA receptor subunit 3B, NMDAR, NMDAR2C, NMDAR2D, NMDE1_HUMAN, NMDE2_HUMAN, NMDE3_HUMAN, NMDE4_HUMAN, NMDZ1_HUMAN, NR1, NR2A, NR2B, NR2C, NR2D, NR3, OTTHUMP00000041930, OTTHUMP00000160135, OTTHUMP00000174531, PPP1R86, Protein phosphatase 1 regulatory subunit 86, SCAR13, Smp_128940, estrogen receptor binding CpG island, glutamate receptor ionotropic NMDA 2D, glutamate receptor ionotropic, NMDA 1, hNR 3, hNR2A, mGlu5, mGluR1, mGluR5

2 Images
Functional Studies - Ibotenic acid, excitotoxic agonist (AB120041)
  • FuncS

PubMed

Functional Studies - Ibotenic acid, excitotoxic agonist (AB120041)

Representative examples of NeuN immunohistochemistry of a complete auditory cortex lesion or sham-operated control section. Rats were anesthetized with halothane and placed in a Kopf stereotaxic apparatus. The skin overlying the skull was disinfected, an incision made, and small burr holes drilled through the skull bone to allow penetration of the injector (Hamilton 1 µl syringe). Bilateral excitotoxic lesions (two per side) were produced by injections of 0.25 µl ibotenic acid (10 µg/µl in 0.1 M sodium phosphate buffer, pH : 7.4; ab120041). The rate of infusion was 0.05 µl/min. The injector was lowered in the brain and left in place 3 min before and 5 min after each injection.

Image from Masini CV et al., Brain Res. 2013;1443:18-26. Fig 1.; doi: 10.1016/j.brainres.2012.01.002 with permission from Elsevier.

Chemical Structure - Ibotenic acid, excitotoxic agonist (AB120041)
  • Chemical Structure

Lab

Chemical Structure - Ibotenic acid, excitotoxic agonist (AB120041)

2D chemical structure image of ab120041, Ibotenic acid, excitotoxic agonist

Key facts

CAS number

2552-55-8

Purity

>98%

Form

Solid

form

Molecular weight

158.11 Da

Molecular formula

C<sub>5</sub>H<sub>6</sub>N<sub>2</sub>O<sub>4</sub>

PubChem

1233

Nature

Synthetic

Biochemical name

Ibotenic acid

Biological description

Neuroexcitatory amino acid originally isolated from Amanita species. Neurotoxin often used to model cognitive dysfunctions. NMDA and metabotropic receptor agonist.

Canonical smiles

C1=C(ONC1=O)C(C(=O)O)N

InChi

InChI=1S/C5H6N2O4/c6-4(5(9)10)2-1-3(8)7-11-2/h1,4H,6H2,(H,7,8)(H,9,10)

InChiKey

IRJCBFDCFXCWGO-UHFFFAOYSA-N

IUPAC Name

2-amino-2-(3-oxo-1,2-oxazol-5-yl)acetic acid

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months

Product protocols

Publications (13)

Recent publications for all applications. Explore the full list and refine your search

Neuron 108:512-525.e4 PubMed32783881

2020

Encoding of 3D Head Orienting Movements in the Primary Visual Cortex.

Applications

Unspecified application

Species

Unspecified reactive species

Grigori Guitchounts,Javier Masís,Steffen B E Wolff,David Cox

Neuron 100:244-258.e12 PubMed30174116

2018

Thalamocortical Axonal Activity in Motor Cortex Exhibits Layer-Specific Dynamics during Motor Learning.

Applications

Unspecified application

Species

Unspecified reactive species

Yasuyo H Tanaka,Yasuhiro R Tanaka,Masashi Kondo,Shin-Ichiro Terada,Yasuo Kawaguchi,Masanori Matsuzaki

Nature communications 6:10088 PubMed26657320

2015

Basolateral and central amygdala differentially recruit and maintain dorsolateral striatum-dependent cocaine-seeking habits.

Applications

Unspecified application

Species

Unspecified reactive species

Jennifer E Murray,Aude Belin-Rauscent,Marine Simon,Chiara Giuliano,Marianne Benoit-Marand,Barry J Everitt,David Belin

Cerebral cortex (New York, N.Y. : 1991) 26:1287-94 PubMed26637448

2015

Evidence for Competition for Target Innervation in the Medial Prefrontal Cortex.

Applications

Unspecified application

Species

Unspecified reactive species

Ramon Guirado,Juzoh Umemori,Pia Sipilä,Eero Castrén

Frontiers in behavioral neuroscience 8:414 PubMed25538581

2014

The subthalamic nucleus keeps you high on emotion: behavioral consequences of its inactivation.

Applications

Unspecified application

Species

Unspecified reactive species

Yann Pelloux,Julie Meffre,Elodie Giorla,Christelle Baunez

Electrophoresis 35:2593-9 PubMed24981810

2014

Determination of muscimol and ibotenic acid in mushrooms of Amanitaceae by capillary electrophoresis.

Applications

Unspecified application

Species

Unspecified reactive species

Anna Poliwoda,Katarzyna Zielińska,Marek Halama,Piotr P Wieczorek

Nature neuroscience 15:1563-71 PubMed23001061

2012

Goal-oriented searching mediated by ventral hippocampus early in trial-and-error learning.

Applications

Unspecified application

Species

Unspecified reactive species

Sarah Ruediger,Dominique Spirig,Flavio Donato,Pico Caroni

Nature neuroscience 15:1454-9 PubMed22983208

2012

Motor circuits are required to encode a sensory model for imitative learning.

Applications

Unspecified application

Species

Unspecified reactive species

Todd F Roberts,Sharon M H Gobes,Malavika Murugan,Bence P Ölveczky,Richard Mooney

Brain research 1443:18-26 PubMed22290179

2012

Auditory cortex lesions do not disrupt habituation of HPA axis responses to repeated noise stress.

Applications

Unspecified application

Species

Unspecified reactive species

Cher V Masini,Jessica A Babb,Tara J Nyhuis,Heidi E W Day,Serge Campeau

Hippocampus 18:1064-73 PubMed18651615

2008

The role of the dentate gyrus, CA3a,b, and CA3c for detecting spatial and environmental novelty.

Applications

Unspecified application

Species

Unspecified reactive species

Michael R Hunsaker,Jenna S Rosenberg,Raymond P Kesner
View all publications

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