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MW 158.11 Da, Purity >98%. Neuroexcitatory amino acid originally isolated from Amanita species. Neurotoxin often used to model cognitive dysfunctions. NMDA and metabotropic receptor agonist.

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Images

Chemical Structure - Ibotenic acid, excitotoxic agonist (AB120041), expandable thumbnail
  • Functional Studies - Ibotenic acid, excitotoxic agonist (AB120041), expandable thumbnail

Publications

Key facts

CAS number
2552-55-8
Purity
> 98%
Form
Solid
Molecular weight
158.11 Da
Molecular formula
C5H6N2O4
PubChem identifier
1233
Nature
Synthetic

Alternative names

Recommended products

MW 158.11 Da, Purity >98%. Neuroexcitatory amino acid originally isolated from Amanita species. Neurotoxin often used to model cognitive dysfunctions. NMDA and metabotropic receptor agonist.

Key facts

Purity
> 98%
PubChem identifier
1233
Biochemical name
Ibotenic acid
Biological description

Neuroexcitatory amino acid originally isolated from Amanita species. Neurotoxin often used to model cognitive dysfunctions. NMDA and metabotropic receptor agonist.

Canonical SMILES
C1=C(ONC1=O)C(C(=O)O)N
InChI
InChI=1S/C5H6N2O4/c6-4(5(9)10)2-1-3(8)7-11-2/h1,4H,6H2,(H,7,8)(H,9,10)
InChIKey
IRJCBFDCFXCWGO-UHFFFAOYSA-N
IUPAC name
2-amino-2-(3-oxo-1,2-oxazol-5-yl)acetic acid

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions, The product can be stored for up to 12 months

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2 product images

  • Chemical Structure - Ibotenic acid, excitotoxic agonist (ab120041), expandable thumbnail

    Chemical Structure - Ibotenic acid, excitotoxic agonist (ab120041)

    2D chemical structure image of ab120041, Ibotenic acid, excitotoxic agonist

  • Functional Studies - Ibotenic acid, excitotoxic agonist (ab120041), expandable thumbnail
    Image from Masini CV et al., Brain Res. 2013;1443:18-26. Fig 1.; doi: 10.1016/j.brainres.2012.01.002 with permission from Elsevier.

    Functional Studies - Ibotenic acid, excitotoxic agonist (ab120041)

    Representative examples of NeuN immunohistochemistry of a complete auditory cortex lesion or sham-operated control section.
    Rats were anesthetized with halothane and placed in a Kopf stereotaxic apparatus. The skin overlying the skull was disinfected, an incision made, and small burr holes drilled through the skull bone to allow penetration of the injector (Hamilton 1 µl syringe). Bilateral excitotoxic lesions (two per side) were produced by injections of 0.25 µl ibotenic acid (10 µg/µl in 0.1 M sodium phosphate buffer, pH: 7.4; ab120041). The rate of infusion was 0.05 µl/min. The injector was lowered in the brain and left in place 3 min before and 5 min after each injection.

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