Ibotenic acid, excitotoxic agonist
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(13 Publications)
MW 158.11 Da, Purity >98%. Neuroexcitatory amino acid originally isolated from Amanita species. Neurotoxin often used to model cognitive dysfunctions. NMDA and metabotropic receptor agonist.
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AW490526, EB11, EIEE27, EPND, FESD, GLUR, GPRC1A, GPRC1E, GRIN 2A, GRIN 2B, GRIN3A, GRIN3B, GRM1-Alpha, GRM1_HUMAN, GRM5_HUMAN, GluN1, GluN2A, GluN2C, GluN2D, Glutamate Receptor Ionotropic N Methyl D Aspartate 2B, Glutamate Receptor Ionotropic N Methyl D Aspartate 2C, Glutamate Receptor Ionotropic N Methyl D Aspartate subunit 2B, Glutamate Receptor Ionotropic N methyl D aspartate 3A, Glutamate [NMDA] receptor subunit epsilon-1, Glutamate [NMDA] receptor subunit epsilon-2, Glutamate [NMDA] receptor subunit epsilon-3, Glutamate [NMDA] receptor subunit epsilon-4, Glutamate [NMDA] receptor subunit zeta-1, Glutamate receptor, Glutamate receptor ionotropic, Glutamate receptor ionotropic N methyl D aspartate 1, Glutamate receptor ionotropic N methyl D aspartate 2A, Glutamate receptor ionotropic N methyl D aspartate 3B, Glutamate receptor ionotropic NMDA2B, Glutamate receptor ionotropic, N-methyl-D aspartate, subunit 1, Glutamate receptor ionotropic, NMDA 2C, Glutamate receptor metabotropic 1, Glutamate receptor metabotropic 5, Glutamate receptor subunit epsilon 2, Glutamate receptor, ionotropic, N-methyl D-aspartate 2D, Glutamate receptor, ionotropic, NMDA2B (epsilon 2), Grin2c, Grin2d, LKS, MGC142178, MGC142180, MGLU1, MRD6, MRD8, Metabotropic glutamate receptor 1, Metabotropic glutamate receptor 5, Metabotropic glutamate receptor 5 variant F, Metabotropic glutamate receptor 5 variant G, Metabotropic glutamate receptor 5 variant H, N Methly D Aspartate Receptor Channel Subunit Epsilon 3, N methyl D asparate receptor channel subunit epsilon 2, N methyl D aspartate receptor channel subunit zeta 1, N methyl D aspartate receptor channel, subunit epsilon 1, N methyl D aspartate receptor subunit 2A, N methyl D aspartate receptor subunit 2B, N methyl D aspartate receptor subunit 2C, N methyl d aspartate receptor subunit 2D, N-methyl D-aspartate receptor subtype 2A, N-methyl D-aspartate receptor subtype 2B, N-methyl D-aspartate receptor subtype 2C, N-methyl D-aspartate receptor subtype 2D, N-methyl-D-aspartate receptor, N-methyl-D-aspartate receptor subunit 3, N-methyl-D-aspartate receptor subunit NR1, NMD-R1, NMDA 1, NMDA 2D, NMDA NR2B, NMDA receptor 1, NMDA receptor subtype 2A, NMDA receptor subunit 3A, NMDA receptor subunit 3B, NMDAR, NMDAR2C, NMDAR2D, NMDE1_HUMAN, NMDE2_HUMAN, NMDE3_HUMAN, NMDE4_HUMAN, NMDZ1_HUMAN, NR1, NR2A, NR2B, NR2C, NR2D, NR3, OTTHUMP00000041930, OTTHUMP00000160135, OTTHUMP00000174531, PPP1R86, Protein phosphatase 1 regulatory subunit 86, SCAR13, Smp_128940, estrogen receptor binding CpG island, glutamate receptor ionotropic NMDA 2D, glutamate receptor ionotropic, NMDA 1, hNR 3, hNR2A, mGlu5, mGluR1, mGluR5
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PubMed
Functional Studies - Ibotenic acid, excitotoxic agonist (AB120041)
Representative examples of NeuN immunohistochemistry of a complete auditory cortex lesion or sham-operated control section. Rats were anesthetized with halothane and placed in a Kopf stereotaxic apparatus. The skin overlying the skull was disinfected, an incision made, and small burr holes drilled through the skull bone to allow penetration of the injector (Hamilton 1 µl syringe). Bilateral excitotoxic lesions (two per side) were produced by injections of 0.25 µl ibotenic acid (10 µg/µl in 0.1 M sodium phosphate buffer, pH : 7.4; ab120041). The rate of infusion was 0.05 µl/min. The injector was lowered in the brain and left in place 3 min before and 5 min after each injection.
Image from Masini CV et al., Brain Res. 2013;1443:18-26. Fig 1.; doi: 10.1016/j.brainres.2012.01.002 with permission from Elsevier.
- Chemical Structure
Lab
Chemical Structure - Ibotenic acid, excitotoxic agonist (AB120041)
2D chemical structure image of ab120041, Ibotenic acid, excitotoxic agonist
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Publications (13)
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Neuron 108:512-525.e4 PubMed32783881
2020
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Neuron 100:244-258.e12 PubMed30174116
2018
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Nature communications 6:10088 PubMed26657320
2015
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Cerebral cortex (New York, N.Y. : 1991) 26:1287-94 PubMed26637448
2015
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Frontiers in behavioral neuroscience 8:414 PubMed25538581
2014
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Electrophoresis 35:2593-9 PubMed24981810
2014
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Nature neuroscience 15:1563-71 PubMed23001061
2012
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Nature neuroscience 15:1454-9 PubMed22983208
2012
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Brain research 1443:18-26 PubMed22290179
2012
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Hippocampus 18:1064-73 PubMed18651615
2008
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