MW 158.11 Da, Purity >98%. Neuroexcitatory amino acid originally isolated from Amanita species. Neurotoxin often used to model cognitive dysfunctions. NMDA and metabotropic receptor agonist.
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- Neuron 108:512-525.e42020Encoding of 3D Head Orienting Movements in the Primary Visual Cortex.Applications:Unspecified applicationReactive species:Unspecified reactive speciesGrigori Guitchounts et. al.PubMed 32783881
- Neuron 100:244-258.e122018Thalamocortical Axonal Activity in Motor Cortex Exhibits Layer-Specific Dynamics during Motor Learning.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYasuyo H Tanaka et. al.PubMed 30174116
- Nature communications 6:100882015Basolateral and central amygdala differentially recruit and maintain dorsolateral striatum-dependent cocaine-seeking habits.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJennifer E Murray et. al.PubMed 26657320
- Cerebral cortex (New York, N.Y. : 1991) 26:1287-942015Evidence for Competition for Target Innervation in the Medial Prefrontal Cortex.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRamon Guirado,Juzoh Umemori,Pia Sipilä,Eero CastrénPubMed 26637448
- Frontiers in behavioral neuroscience 8:4142014The subthalamic nucleus keeps you high on emotion: behavioral consequences of its inactivation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYann Pelloux,Julie Meffre,Elodie Giorla,Christelle BaunezPubMed 25538581
- Electrophoresis 35:2593-92014Determination of muscimol and ibotenic acid in mushrooms of Amanitaceae by capillary electrophoresis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAnna Poliwoda et. al.PubMed 24981810
- Nature neuroscience 15:1563-712012Goal-oriented searching mediated by ventral hippocampus early in trial-and-error learning.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSarah Ruediger et. al.PubMed 23001061
- Nature neuroscience 15:1454-92012Motor circuits are required to encode a sensory model for imitative learning.Applications:Unspecified applicationReactive species:Unspecified reactive speciesTodd F Roberts,Sharon M H Gobes,Malavika Murugan,Bence P Ölveczky,Richard MooneyPubMed 22983208
- Brain research 1443:18-262012Auditory cortex lesions do not disrupt habituation of HPA axis responses to repeated noise stress.Applications:Unspecified applicationReactive species:Unspecified reactive speciesCher V Masini,Jessica A Babb,Tara J Nyhuis,Heidi E W Day,Serge CampeauPubMed 22290179
- Hippocampus 18:1064-732008The role of the dentate gyrus, CA3a,b, and CA3c for detecting spatial and environmental novelty.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMichael R Hunsaker,Jenna S Rosenberg,Raymond P KesnerPubMed 18651615
Key facts
- CAS number
- 2552-55-8
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 158.11 Da
- Molecular formula
- C5H6N2O4
- PubChem identifier
- 1233
- Nature
- Synthetic
Target data
Alternative names
AW490526, EB11, EIEE27, EPND, FESD, GLUR, GPRC1A, GPRC1E, GRIN 2A, GRIN 2B, GRIN3A, GRIN3B, GRM1-Alpha, GRM1_HUMAN, GRM5_HUMAN, GluN1, GluN2A, GluN2C, GluN2D, Glutamate Receptor Ionotropic N Methyl D Aspartate 2B, Glutamate Receptor Ionotropic N Methyl D Aspartate 2C, Glutamate Receptor Ionotropic N Methyl D Aspartate subunit 2B, Glutamate Receptor Ionotropic N methyl D aspartate 3A, Glutamate [NMDA] receptor subunit epsilon-1, Glutamate [NMDA] receptor subunit epsilon-2, Glutamate [NMDA] receptor subunit epsilon-3, Glutamate [NMDA] receptor subunit epsilon-4, Glutamate [NMDA] receptor subunit zeta-1, Glutamate receptor, Glutamate receptor ionotropic, Glutamate receptor ionotropic N methyl D aspartate 1, Glutamate receptor ionotropic N methyl D aspartate 2A, Glutamate receptor ionotropic N methyl D aspartate 3B, Glutamate receptor ionotropic NMDA2B, Glutamate receptor ionotropic, N-methyl-D aspartate, subunit 1, Glutamate receptor ionotropic, NMDA 2C, Glutamate receptor metabotropic 1, Glutamate receptor metabotropic 5, Glutamate receptor subunit epsilon 2, Glutamate receptor, ionotropic, N-methyl D-aspartate 2D, Glutamate receptor, ionotropic, NMDA2B (epsilon 2), Grin2c, Grin2d, LKS, MGC142178, MGC142180, MGLU1, MRD6, MRD8, Metabotropic glutamate receptor 1, Metabotropic glutamate receptor 5, Metabotropic glutamate receptor 5 variant F, Metabotropic glutamate receptor 5 variant G, Metabotropic glutamate receptor 5 variant H, N Methly D Aspartate Receptor Channel Subunit Epsilon 3, N methyl D asparate receptor channel subunit epsilon 2, N methyl D aspartate receptor channel subunit zeta 1, N methyl D aspartate receptor channel, subunit epsilon 1, N methyl D aspartate receptor subunit 2A, N methyl D aspartate receptor subunit 2B, N methyl D aspartate receptor subunit 2C, N methyl d aspartate receptor subunit 2D, N-methyl D-aspartate receptor subtype 2A, N-methyl D-aspartate receptor subtype 2B, N-methyl D-aspartate receptor subtype 2C, N-methyl D-aspartate receptor subtype 2D, N-methyl-D-aspartate receptor, N-methyl-D-aspartate receptor subunit 3, N-methyl-D-aspartate receptor subunit NR1, NMD-R1, NMDA 1, NMDA 2D, NMDA NR2B, NMDA receptor 1, NMDA receptor subtype 2A, NMDA receptor subunit 3A, NMDA receptor subunit 3B, NMDAR, NMDAR2C, NMDAR2D, NMDE1_HUMAN, NMDE2_HUMAN, NMDE3_HUMAN, NMDE4_HUMAN, NMDZ1_HUMAN, NR1, NR2A, NR2B, NR2C, NR2D, NR3, OTTHUMP00000041930, OTTHUMP00000160135, OTTHUMP00000174531, PPP1R86, Protein phosphatase 1 regulatory subunit 86, SCAR13, Smp_128940, estrogen receptor binding CpG island, glutamate receptor ionotropic NMDA 2D, glutamate receptor ionotropic, NMDA 1, hNR 3, hNR2A, mGlu5, mGluR1, mGluR5
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MW 158.11 Da, Purity >98%. Neuroexcitatory amino acid originally isolated from Amanita species. Neurotoxin often used to model cognitive dysfunctions. NMDA and metabotropic receptor agonist.
Key facts
- CAS number
- 2552-55-8
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 158.11 Da
- Molecular formula
- C5H6N2O4
- PubChem identifier
- 1233
- Nature
- Synthetic
- Biochemical name
- Ibotenic acid
- Biological description
Neuroexcitatory amino acid originally isolated from Amanita species. Neurotoxin often used to model cognitive dysfunctions. NMDA and metabotropic receptor agonist.
- Canonical SMILES
- C1=C(ONC1=O)C(C(=O)O)N
- InChI
- InChI=1S/C5H6N2O4/c6-4(5(9)10)2-1-3(8)7-11-2/h1,4H,6H2,(H,7,8)(H,9,10)
- InChIKey
- IRJCBFDCFXCWGO-UHFFFAOYSA-N
- IUPAC name
- 2-amino-2-(3-oxo-1,2-oxazol-5-yl)acetic acid
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
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2 product images
Chemical Structure - Ibotenic acid, excitotoxic agonist (ab120041)
2D chemical structure image of ab120041, Ibotenic acid, excitotoxic agonist
Image from Masini CV et al., Brain Res. 2013;1443:18-26. Fig 1.; doi: 10.1016/j.brainres.2012.01.002 with permission from Elsevier.Functional Studies - Ibotenic acid, excitotoxic agonist (ab120041)
Representative examples of NeuN immunohistochemistry of a complete auditory cortex lesion or sham-operated control section.
Rats were anesthetized with halothane and placed in a Kopf stereotaxic apparatus. The skin overlying the skull was disinfected, an incision made, and small burr holes drilled through the skull bone to allow penetration of the injector (Hamilton 1 µl syringe). Bilateral excitotoxic lesions (two per side) were produced by injections of 0.25 µl ibotenic acid (10 µg/µl in 0.1 M sodium phosphate buffer, pH: 7.4; ab120041). The rate of infusion was 0.05 µl/min. The injector was lowered in the brain and left in place 3 min before and 5 min after each injection.
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