Ibotenic acid (mM/ml), excitotoxic agonist
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MW 158.11 Da, Purity >98%. Neuroexcitatory amino acid originally isolated from Amanita species. Neurotoxin often used to model cognitive dysfunctions. NMDA and metabotropic receptor agonist.
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AW490526, EB11, EIEE27, EPND, FESD, GLUR, GPRC1A, GPRC1E, GRIN 2A, GRIN 2B, GRIN3A, GRIN3B, GRM1-Alpha, GRM1_HUMAN, GRM5_HUMAN, GluN1, GluN2A, GluN2C, GluN2D, Glutamate Receptor Ionotropic N Methyl D Aspartate 2B, Glutamate Receptor Ionotropic N Methyl D Aspartate 2C, Glutamate Receptor Ionotropic N Methyl D Aspartate subunit 2B, Glutamate Receptor Ionotropic N methyl D aspartate 3A, Glutamate [NMDA] receptor subunit epsilon-1, Glutamate [NMDA] receptor subunit epsilon-2, Glutamate [NMDA] receptor subunit epsilon-3, Glutamate [NMDA] receptor subunit epsilon-4, Glutamate [NMDA] receptor subunit zeta-1, Glutamate receptor, Glutamate receptor ionotropic, Glutamate receptor ionotropic N methyl D aspartate 1, Glutamate receptor ionotropic N methyl D aspartate 2A, Glutamate receptor ionotropic N methyl D aspartate 3B, Glutamate receptor ionotropic NMDA2B, Glutamate receptor ionotropic, N-methyl-D aspartate, subunit 1, Glutamate receptor ionotropic, NMDA 2C, Glutamate receptor metabotropic 1, Glutamate receptor metabotropic 5, Glutamate receptor subunit epsilon 2, Glutamate receptor, ionotropic, N-methyl D-aspartate 2D, Glutamate receptor, ionotropic, NMDA2B (epsilon 2), Grin2c, Grin2d, LKS, MGC142178, MGC142180, MGLU1, MRD6, MRD8, Metabotropic glutamate receptor 1, Metabotropic glutamate receptor 5, Metabotropic glutamate receptor 5 variant F, Metabotropic glutamate receptor 5 variant G, Metabotropic glutamate receptor 5 variant H, N Methly D Aspartate Receptor Channel Subunit Epsilon 3, N methyl D asparate receptor channel subunit epsilon 2, N methyl D aspartate receptor channel subunit zeta 1, N methyl D aspartate receptor channel, subunit epsilon 1, N methyl D aspartate receptor subunit 2A, N methyl D aspartate receptor subunit 2B, N methyl D aspartate receptor subunit 2C, N methyl d aspartate receptor subunit 2D, N-methyl D-aspartate receptor subtype 2A, N-methyl D-aspartate receptor subtype 2B, N-methyl D-aspartate receptor subtype 2C, N-methyl D-aspartate receptor subtype 2D, N-methyl-D-aspartate receptor, N-methyl-D-aspartate receptor subunit 3, N-methyl-D-aspartate receptor subunit NR1, NMD-R1, NMDA 1, NMDA 2D, NMDA NR2B, NMDA receptor 1, NMDA receptor subtype 2A, NMDA receptor subunit 3A, NMDA receptor subunit 3B, NMDAR, NMDAR2C, NMDAR2D, NMDE1_HUMAN, NMDE2_HUMAN, NMDE3_HUMAN, NMDE4_HUMAN, NMDZ1_HUMAN, NR1, NR2A, NR2B, NR2C, NR2D, NR3, OTTHUMP00000041930, OTTHUMP00000160135, OTTHUMP00000174531, PPP1R86, Protein phosphatase 1 regulatory subunit 86, SCAR13, Smp_128940, estrogen receptor binding CpG island, glutamate receptor ionotropic NMDA 2D, glutamate receptor ionotropic, NMDA 1, hNR 3, hNR2A, mGlu5, mGluR1, mGluR5
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Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
These glutamate receptors contribute to neuronal communication and development. NMDARs which are ionotropic channels modulate calcium ion flow upon activation impacting synaptic strength and plasticity. They often form heteromeric complexes with other subunits creating channels with distinct functional properties. In contrast mGluRs like mGluR1a and mGluR5 are G protein-coupled receptors that link to intracellular signaling pathways affecting synaptic modulation and plasticity differently. These receptors are essential for processes like learning memory formation and higher cognitive functions.
Pathways
These glutamate receptors are involved in excitatory synaptic transmission and neuroplasticity-related pathways. NMDARs are central to the glutamatergic signaling pathway and have relationships with proteins such as CaMKII and PSD-95 which participate in strengthening synaptic connections. Metabotropic glutamate receptors interact with intracellular pathways involving proteins like PLC and PI3K which regulate calcium release and neurotransmitter signaling. These pathways ensure proper neuronal communication and adaptability.
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