MW 230.31 Da, Purity >98%. Non-selective PDE inhibitor (IC50 values are 53, 35, 48, 12 and 10 μM for PDE Ia, II, III, IV and V respectively). Anti-inflammatory agent. Inhibits platelet aggregation. Centrally active via glial cell attenuation. Shows bronchodilatory, vasodilatory and neuroprotective effects in vivo. Orally active. Blood-brain barrier permeable.
View Alternative Names
5''-cyclic phosphodiesterase 4A, 5''-cyclic phosphodiesterase 4B, 5''-cyclic phosphodiesterase 4C, 5''-cyclic phosphodiesterase 4D, ACLS, CP2D6_HUMAN, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, Cholesterol 25-hydroxylase, Cytochrome P450 2D6, Cytochrome P450 family 2 subfamily D member 6, Cytochrome P450 family 2 subfamily D polypeptide 6, Cytochrome P450-DB1, DKFZp686F2182, DKFZp686M11213, DNA binding protein, DPDE 1, DPDE2, DPDE3, DPDE4, Debrisoquine 4-hydroxylase, Dunce like phosphodiesterase E3, FLJ97311, GCPS, GLI Kruppel family member GLI 3, GLI Kruppel family member GLI3 (Greig cephalopolysyndactyly syndrome), GLI family zinc finger 3, GLI3 C-terminally truncated form, GLI3 form of 190 kDa, GLI3 form of 83 kDa, GLI3 full length protein, GLI3-190, GLI3-83, GLI3FL, GLI3_HUMAN, Glioma associated oncogene family zinc finger 3, HSPDE4D, MGC126222, MGC126529, Microsomal monooxygenase, OTTHUMP00000010652, OTTHUMP00000010653, OTTHUMP00000010654, OTTHUMP00000010656, OTTHUMP00000232365, Oncogene GLI3, P450 DB1, P450C2D, PAP A, PAPB, PDE 21, PDE IVB, PDE32, PDE4, PDE43, PDE46, PDE4A11, PDE4A_HUMAN, PDE4B5, PDE4B_HUMAN, PDE4C_HUMAN, PDE4DN2, PDE4D_HUMAN, PPD IV, Phosphodiesterase 4A, Phosphodiesterase 4A, cAMP-specific (dunce, Phosphodiesterase 4B, Phosphodiesterase 4B cAMP specific, Phosphodiesterase 4B, cAMP specific (phosphodiesterase E4 dunce homolog, Drosophila), Phosphodiesterase 4C, Phosphodiesterase 4C cAMP specific, Phosphodiesterase 4C, cAMP specific (phosphodiesterase E1 dunce homolog, Drosophila), Phosphodiesterase 4D cAMP specific (dunce (Drosophila) homolog phosphodiesterase E3), Phosphodiesterase 4D cAMP specific (phosphodiesterase E3 dunce homolog Drosophila), Phosphodiesterase 4D cAMP-specific, Phosphodiesterase 4D, cAMP specific (dunce), Phosphodiesterase E1 dunce homolog, Phosphodiesterase E1 dunce homolog Drosophila, Phosphodiesterase E2 dunce homolog, Drosophila, Phosphodiesterase type 4C, STRK1, Transcriptional activator GLI3, Transcriptional repressor GLI3R, Xenobiotic monooxygenase, Zinc finger protein GLI 3, cAMP specific 3' 5' cyclic phosphodiesterase 4C, cAMP specific 3',5' cyclic phosphodiesterase 4D, cAMP specific phosphodiesterase, cAMP specific phosphodiesterase 4D, cAMP specific phosphodiesterase PDE4D6, cAMP-specific 3'', cAMP-specific 3',5'-cyclic phosphodiesterase 4A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B, cAMP-specific phosphodiesterase-4 B isoform, dunce like phosphodiesterase E2, dunce-like phosphodiesterase E4, flavoprotein-linked monooxygenase, phosphodiesterase 4A cAMP specific, phosphodiesterase E2 dunce homolog, phosphodiesterase isozyme 4, phosphodiesterase type 4A11
- Chemical Structure
Lab
Chemical Structure - Ibudilast, PDE inhibitor (AB143333)
2D chemical structure image of ab143333, Ibudilast, PDE inhibitor
Properties and storage information
Shipped at conditions
Appropriate long-term storage conditions
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Gli3 functions in gene expression regulation and limb development. It acts as a transcriptional activator or repressor depending on cellular context and interacting partners contributing to embryonic developmental processes. CYP2D6 is an important component of drug metabolism affecting the pharmacokinetics of many medications. PDE4 family members serve to modulate cellular responses to cAMP playing roles in processes such as inflammation and cognition. These phosphodiesterases are part of a larger signaling complex that prevents excessive cAMP accumulation by breaking it down essential for maintaining proper cellular signaling balance.
Pathways
Gli3 plays a role in the Hedgehog and Notch signaling pathways where it interacts with other proteins like Sonic Hedgehog (SHH) and Patched (PTCH). This involvement is important in developmental biology and pattern formation. CYP2D6 is involved in the hepatic drug metabolism pathway related closely to its cytochrome P450 family members that aid in oxidizing xenobiotic compounds. PDE4 isoforms are part of the cAMP signaling pathway modulating various cellular reactions and interacting with cyclic AMP response element-binding protein (CREB) to influence CREB-mediated transcriptional activities.
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