IC 261, CK1delta and CK1epsilon inhibitor

Key facts

CAS number

186611-52-9

Purity

>99%

Form

Solid

form

Molecular weight

311.3 Da

Molecular formula

C₁₈H₁₇NO₄

PubChem

5353678

Nature

Synthetic

Solubility

Soluble in DMSO to 50 mM

Biochemical name

(3Z)-3-[(2,4,6-trimethoxyphenyl)methylidene]-1H-indol-2-one

Biological description

Selective CK1δ and CK1ε inhibitor. Potent microtubulin polymerization inhibitor. Induces cell cycle arrest and apoptosis. Selectively inhibits tumor cells growth. Shows antitumor effects in vivo.

Canonical smiles

COC1=CC(=C(C(=C1)OC)C=C2C3=CC=CC=C3NC2=O)OC

Isomeric smiles

COC1=CC(=C(C(=C1)OC)/C=C\2/C3=CC=CC=C3NC2=O)OC

InChi

InChI=1S/C18H17NO4/c1-21-11-8-16(22-2)14(17(9-11)23-3)10-13-12-6-4-5-7-15(12)19-18(13)20/h4-10H,1-3H3,(H,19,20)/b13-10-

InChiKey

JBJYTZXCZDNOJW-RAXLEYEMSA-N

IUPAC Name

(3Z)-3-[(2,4,6-trimethoxyphenyl)methylidene]-1H-indol-2-one