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AB120808

ICI 118551 hydrochloride, beta2 adrenoceptor antagonist

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(5 Publications)

MW 313.9 Da, Purity >99%. Highly selective β2 adrenoceptor antagonist (Ki values are 1.2, 120 and 257 nM at β2, β1 and β3 receptors, respectively). Blood-brain barrier permeable. Decreases vascular tone *in vivo*.
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Chemical Structure - ICI 118551 hydrochloride, beta2 adrenoceptor antagonist (AB120808)
  • Chemical Structure

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Chemical Structure - ICI 118551 hydrochloride, beta2 adrenoceptor antagonist (AB120808)

2D chemical structure image of ab120808, ICI 118551 hydrochloride, beta2 adrenoceptor antagonist

Key facts

CAS number

72795-04-1

Purity

>99%

Form

Solid

form

Molecular weight

313.9 Da

Molecular formula

C<sub>1</sub><sub>7</sub>H<sub>2</sub><sub>8</sub>ClNO<sub>2</sub>

PubChem

25102594

Nature

Synthetic

Solubility

Soluble in water to 10 mM

Soluble in DMSO to 10 mM

Biochemical name

ICI 118,551 hydrochloride

Biological description

Highly selective β2 adrenoceptor antagonist (Ki values are 1.2, 120 and 257 nM at β2, β1 and β3 receptors, respectively). Blood-brain barrier permeable. Decreases vascular tone *in vivo*.

Canonical smiles

CC1=C2CCCC2=C(C=C1)OCC(C(C)NC(C)C)O.Cl

Isomeric smiles

CC1=C2CCCC2=C(C=C1)OC[C@@H]([C@H](C)NC(C)C)O.Cl

InChi

InChI=1S/C17H27NO2.ClH/c1-11(2)18-13(4)16(19)10-20-17-9-8-12(3)14-6-5-7-15(14)17;/h8-9,11,13,16,18-19H,5-7,10H2,1-4H3;1H/t13-,16-;/m0./s1

InChiKey

KBXMBGWSOLBOQM-LINSIKMZSA-N

IUPAC Name

(2R,3S)-1-[(7-methyl-2,3-dihydro-1H-inden-4-yl)oxy]-3-(propan-2-ylamino)butan-2-ol;hydrochloride

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Journal of Cancer 13:2258-2270 PubMed35517411

2022

PlexinA1 activation induced by β2-AR promotes epithelial-mesenchymal transition through JAK-STAT3 signaling in human gastric cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Ying Liu,Yanhui Hao,Hanzheng Zhao,Ying Zhang,Die Cheng,Li Zhao,Yuqiao Peng,Yanjie Lu,Yuhong Li

Neurourology and urodynamics 39:1292-1303 PubMed32330364

2020

β-Adrenoceptors regulate matrix metalloproteinase expression in human urothelial cells under hydrostatic pressure.

Applications

Unspecified application

Species

Unspecified reactive species

Jianhua Lan,Tao Jin,Jianzhong Ai,Xin Wei,Zhihui Huang,Hua Chen,Xi Jin,Zhumei Luo,Kunjie Wang

eLife 8: PubMed31500698

2019

MRGPRX4 is a bile acid receptor for human cholestatic itch.

Applications

Unspecified application

Species

Unspecified reactive species

Huasheng Yu,Tianjun Zhao,Simin Liu,Qinxue Wu,Omar Johnson,Zhaofa Wu,Zihao Zhuang,Yaocheng Shi,Luxin Peng,Renxi He,Yong Yang,Jianjun Sun,Xiaoqun Wang,Haifeng Xu,Zheng Zeng,Peng Zou,Xiaoguang Lei,Wenqin Luo,Yulong Li

Journal of cellular biochemistry 120:17872-17886 PubMed31161623

2019

β-Adrenoceptor signaling regulates proliferation and contraction of human bladder smooth muscle cells under pathological hydrostatic pressure.

Applications

Unspecified application

Species

Unspecified reactive species

Junyu Lai,Jianzhong Ai,Deyi Luo,Tao Jin,Banghua Liao,Liang Zhou,Shijian Feng,Xi Jin,Hong Li,Kunjie Wang

Human molecular genetics 27:1556-1564 PubMed29462491

2018

The beta-adrenergic agonist salbutamol modulates neuromuscular junction formation in zebrafish models of human myasthenic syndromes.

Applications

Unspecified application

Species

Unspecified reactive species

Grace McMacken,Dan Cox,Andreas Roos,Juliane Müller,Roger Whittaker,Hanns Lochmüller
View all publications
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