MW 313.9 Da, Purity >99%. Highly selective β2 adrenoceptor antagonist (Ki values are 1.2, 120 and 257 nM at β2, β1 and β3 receptors, respectively). Blood-brain barrier permeable. Decreases vascular tone *in vivo*.
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- Journal of Cancer 13:2258-22702022PlexinA1 activation induced by β2-AR promotes epithelial-mesenchymal transition through JAK-STAT3 signaling in human gastric cancer cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYing Liu,Yanhui Hao,Hanzheng Zhao,Ying Zhang,Die Cheng,Li Zhao,Yuqiao Peng,Yanjie Lu,Yuhong LiPubMed 35517411
- Neurourology and urodynamics 39:1292-13032020β-Adrenoceptors regulate matrix metalloproteinase expression in human urothelial cells under hydrostatic pressure.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJianhua Lan,Tao Jin,Jianzhong Ai,Xin Wei,Zhihui Huang,Hua Chen,Xi Jin,Zhumei Luo,Kunjie WangPubMed 32330364
- eLife 8:2019MRGPRX4 is a bile acid receptor for human cholestatic itch.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHuasheng Yu et. al.PubMed 31500698
- Journal of cellular biochemistry 120:17872-178862019β-Adrenoceptor signaling regulates proliferation and contraction of human bladder smooth muscle cells under pathological hydrostatic pressure.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJunyu Lai et. al.PubMed 31161623
- Human molecular genetics 27:1556-15642018The beta-adrenergic agonist salbutamol modulates neuromuscular junction formation in zebrafish models of human myasthenic syndromes.Applications:Unspecified applicationReactive species:Unspecified reactive speciesGrace McMacken,Dan Cox,Andreas Roos,Juliane Müller,Roger Whittaker,Hanns LochmüllerPubMed 29462491
Key facts
- CAS number
- 72795-04-1
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 313.9 Da
- Molecular formula
- C17H28ClNO2
- PubChem identifier
- 25102594
- Nature
- Synthetic
Recommended products
MW 313.9 Da, Purity >99%. Highly selective β2 adrenoceptor antagonist (Ki values are 1.2, 120 and 257 nM at β2, β1 and β3 receptors, respectively). Blood-brain barrier permeable. Decreases vascular tone *in vivo*.
Key facts
- CAS number
- 72795-04-1
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 313.9 Da
- Molecular formula
- C17H28ClNO2
- PubChem identifier
- 25102594
- Nature
- Synthetic
- Solubility
Soluble in water to 10 mM.
Soluble in DMSO to 10 mM.
- Biochemical name
- ICI 118,551 hydrochloride
- Biological description
Highly selective β2 adrenoceptor antagonist (Ki values are 1.2, 120 and 257 nM at β2, β1 and β3 receptors, respectively). Blood-brain barrier permeable. Decreases vascular tone *in vivo*.
- Canonical SMILES
- CC1=C2CCCC2=C(C=C1)OCC(C(C)NC(C)C)O.Cl
- Isomeric SMILES
- CC1=C2CCCC2=C(C=C1)OC[C@@H]([C@H](C)NC(C)C)O.Cl
- InChI
- InChI=1S/C17H27NO2.ClH/c1-11(2)18-13(4)16(19)10-20-17-9-8-12(3)14-6-5-7-15(14)17;/h8-9,11,13,16,18-19H,5-7,10H2,1-4H3;1H/t13-,16-;/m0./s1
- InChIKey
- KBXMBGWSOLBOQM-LINSIKMZSA-N
- IUPAC name
- (2R,3S)-1-[(7-methyl-2,3-dihydro-1H-inden-4-yl)oxy]-3-(propan-2-ylamino)butan-2-ol;hydrochloride
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- Ambient
- Appropriate long-term storage conditions
- Ambient
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
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1 product image
Chemical Structure - ICI 118551 hydrochloride, beta2 adrenoceptor antagonist (ab120808)
2D chemical structure image of ab120808, ICI 118551 hydrochloride, beta2 adrenoceptor antagonist
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