AB120131

ICI 182,780, Estrogen receptor antagonist

Name: ICI 182,780, Estrogen receptor antagonist (CAS 129453-61-8) | Abcam
Brand: Abcam Limited
SKU: AB120131
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(10 Publications)

MW 606.8 Da, Purity >99%. Estrogen receptor antagonist with no partial agonist activity. Anticancer agent (IC₅₀ = 0.29 nM for inhibition of breast cancer cell growth). Causes downregulation and loss of estrogen receptors.

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Functional Studies - ICI 182,780, Estrogen receptor antagonist (AB120131)

FuncS

Unknown

Functional Studies - ICI 182,780, Estrogen receptor antagonist (AB120131)

ab47489 staining BCL2 in MCF7 cells treated with ICI 182,780 (ab120131), by ICC/IF. Decrease in BCL2 expression correlates with increased concentration of ICI 182,780 as described in literature.
The cells were incubated at 37°C for 3h in media containing different concentrations of ab120131 (ICI 182,780) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab47489 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight^® 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Chemical Structure - ICI 182,780, Estrogen receptor antagonist (AB120131)

Chemical Structure

Lab

Chemical Structure - ICI 182,780, Estrogen receptor antagonist (AB120131)

2D chemical structure image of ab120131, ICI 182,780, Estrogen receptor antagonist

Key facts

CAS number

129453-61-8

Purity

>99%

Form

Solid

form

Molecular weight

606.8 Da

Molecular formula

C32H47F5O3S

PubChem

17756771

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Soluble in ethanol to 50 mM

Biochemical name

(1S,9R,11S,14S,15S)-15-methyl-9-[9-(4,4,5,5,5-pentafluoropentanesulfinyl)nonyl]tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2(7),3,5-triene-5,14-diol

Biological description

Estrogen receptor antagonist with no partial agonist activity. Anticancer agent (IC₅₀ = 0.29 nM for inhibition of breast cancer cell growth). Causes downregulation and loss of estrogen receptors.

Canonical smiles

CC12CCC3C(C1CCC2O)C(CC4=C3C=CC(=C4)O)CCCCCCCCCS(=O)CCCC(C(F)(F)F)(F)F

Isomeric smiles

C[C@]12CC[C@H]3C([C@@H]1CC[C@@H]2O)[C@@H](CC4=C3C=CC(=C4)O)CCCCCCCCCS(=O)CCCC(C(F)(F)F)(F)F

InChi

InChI=1S/C32H47F5O3S/c1-30-17-15-26-25-12-11-24(38)21-23(25)20-22(29(26)27(30)13-14-28(30)39)10-7-5-3-2-4-6-8-18-41(40)19-9-16-31(33,34)32(35,36)37/h11-12,21-22,26-29,38-39H,2-10,13-20H2,1H3/t22-,26-,27+,28+,29?,30+,41?/m1/s1

InChiKey

VWUXBMIQPBEWFH-LQKBAPIOSA-N

IUPAC Name

(7R,9S,13S,14S,17S)-13-methyl-7-[9-(4,4,5,5,5-pentafluoropentylsulfinyl)nonyl]-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol

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Properties and storage information

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate short-term storage conditions

Ambient

Appropriate long-term storage conditions

Ambient

Storage information

The product can be stored for up to 12 months

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Product protocols

Visit the General protocols
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Publications (10)

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Genome biology 26:89 PubMed40200339

2025

The histone acetyltransferase CBP participates in regulating the DNA damage response through ATM after double-strand breaks.

Applications

Unspecified application

Species

Unspecified reactive species

Wafaa S Ramadan,Samrein B M Ahmed,Iman M Talaat,Lama Lozon,Soraya Mouffak,Timo Gemoll,Wael Y Mansour,Raafat El-Awady

Cells 13: PubMed39682775

2024

Extract of Ameliorates Postmenopausal Osteoporosis by Promoting Osteoblast Proliferation and Differentiation.

Applications

Unspecified application

Species

Unspecified reactive species

Ying Wang,Xueru Wang,Kaijin Wang,Weiwei Qin,Ning Li

Molecular therapy. Nucleic acids 29:836-851 PubMed36159594

2022

A novel oncogenic enhancer of estrogen receptor-positive breast cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Chunjie Bao,Jialun Duan,Ying Xie,Yixuan Liu,Peishan Li,Jianwei Li,Huihui Zhao,Haitao Guo,Yanchen Men,Yuxin Ren,Jiarui Xu,Guiling Wang,Wanliang Lu

The Journal of biological chemistry 294:15577-15592 PubMed31439665

2019

17β-Estradiol nongenomically induces vascular endothelial HS release by promoting phosphorylation of cystathionine γ-lyase.

Applications

Unspecified application

Species

Unspecified reactive species

Xingyan Xu,Qing Yan,Xiaoyun Liu,Ping Li,Xiaosa Li,Yiwen Chen,Tommaso Simoncini,Junxiu Liu,Dongxing Zhu,Xiaodong Fu

Reproductive biology and endocrinology : RB&E 17:1 PubMed30606208

2019

Profile of melatonin and its receptors and synthesizing enzymes in cumulus-oocyte complexes of the developing sheep antral follicle-a potential estradiol-mediated mechanism.

Applications

Unspecified application

Species

Unspecified reactive species

Longfei Xiao,Junjie Hu,Liangli Song,Yong Zhang,Weitao Dong,Yuting Jiang,Quanwei Zhang,Ligang Yuan,Xingxu Zhao

Oncogene 38:1019-1037 PubMed30190545

2018

Role of SUMOylation in differential ERα transcriptional repression by tamoxifen and fulvestrant in breast cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Tatiana Traboulsi,Mohamed El Ezzy,Vanessa Dumeaux,Eric Audemard,Sylvie Mader

BMC complementary and alternative medicine 18:107 PubMed29566679

2018

The in vitro estrogenic activity of the crude drugs found in Japanese herbal medicines prescribed for menopausal syndrome was enhanced by combining them.

Applications

Unspecified application

Species

Unspecified reactive species

Zeyun Wang,Seiji Kanda,Takaki Shimono,Dambajamts Enkh-Undraa,Toshimasa Nishiyama

Scientific reports 7:8486 PubMed28814778

2017

In vivo and in vitro sex differences in the dendritic morphology of developing murine hippocampal and cortical neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Kimberly P Keil,Sunjay Sethi,Machelle D Wilson,Hao Chen,Pamela J Lein

PloS one 9:e95878 PubMed24789043

2014

Induction of the CLOCK gene by E2-ERα signaling promotes the proliferation of breast cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Liyun Xiao,Alan K Chang,Ming-Xi Zang,Hailian Bi,Shujing Li,Miao Wang,Xinrong Xing,Huijian Wu

Journal of molecular endocrinology 51:1-13 PubMed23576686

2013

A novel first exon directs hormone-sensitive transcription of the pig prolactin receptor.

Applications

Unspecified application

Species

Unspecified reactive species

Anke Schennink,Josephine F Trott,Bradley A Freking,Russell C Hovey

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ICI 182,780, Estrogen receptor antagonist

Functional Studies - ICI 182,780, Estrogen receptor antagonist (AB120131)

Chemical Structure - ICI 182,780, Estrogen receptor antagonist (AB120131)

Key facts

CAS number

Purity

Form

Molecular weight

Molecular formula

PubChem

Nature

Solubility

Biochemical name

Biological description

Canonical smiles

Isomeric smiles

InChi

InChiKey

IUPAC Name

Properties and storage information

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Product protocols

Publications (10)

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