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AB141130

Idazoxan hydrochloride, alpha2 Adrenoceptor antagonist and I2 ligand

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MW 240.68 Da, Purity >99%. α2 Adrenoceptor antagonist and I2 ligand. Improves motor symptoms and decreases dyskinesia in Parkinson's disease models. Also induces apoptosis. Active *in vivo*.

View Alternative Names

ADA1D_HUMAN, ADA2A_HUMAN, ADA2C_HUMAN, ADRA1A, ADRA1L1, ADRA2, ADRA2A, ADRA2L2, ADRA2R, ADRA2RL1, ADRA2RL2, ADRAR, ADRARL1, ADRARL2, AI838772, AW493413, Adra 2c, Adra1d, Adrenergic alpha 1A receptor, Adrenergic alpha 1B receptor, Adrenergic alpha 1C receptor, Adrenergic alpha 1D receptor, Adrenergic alpha 2A receptor, Adrenergic alpha 2C receptor, Adrenoceptor alpha 2C, Alpha 2 adrenergic receptor subtype C2, Alpha 2AAR subtype C10, Alpha 2B adrenoceptor, Alpha 2B adrenoreceptor, Alpha 2C adrenergic receptor subtype C4, Alpha adrenergic receptor 1b, Alpha adrenergic receptor 1d, Alpha-1A adrenergic receptor, Alpha-1A adrenoreceptor, Alpha-1C adrenergic receptor, Alpha-1D adrenergic receptor, Alpha-1D adrenoceptor, Alpha-1D adrenoreceptor, Alpha-2 adrenergic receptor subtype C10, Alpha-2 adrenergic receptor subtype C4, Alpha-2-adrenergic receptor, renal type, Alpha-2A adrenergic receptor, Alpha-2A adrenoceptor, Alpha-2A adrenoreceptor, Alpha-2AAR, Alpha-2C adrenergic receptor, Alpha-2C adrenoceptor, Alpha-2C adrenoreceptor, Alpha-2CAR, Alpha-adrenergic receptor 1a, Alpha-adrenergic receptor 1c, DNA replication inhibitor, ERR a, ERR-alpha, ERR1 protein, ERR1_HUMAN, ESRL 1, ESRR A, Estrogen receptor related 1, Estrogen receptor-like 1, Estrogen-related receptor alpha, Estrra, FLJ11090, GEMI_HUMAN, GMNN, Geminin, Geminin DNA replication inhibitor, MGC104252, MGC112732, NR3B1, Nuclear receptor subfamily 3 group B member 1, OTTHUMP00000039393, OTTHUMP00000058849, RP24-311F12.2, RP3 369A17.3, SCAN1, Steroid hormone receptor ERR1, Subtype alpha2 C4, TYDP, TYDP1_HUMAN, Tyr-DNA phosphodiesterase 1, Tyrosyl-DNA phosphodiesterase 1, alpha 2BAR, alpha-2-adrenergic receptor, platelet type, alpha2 AR C4, alpha2 C4, alpha2C, alpha2cii-adrenergic receptor, estrogen receptor related receptor alpha, hERR1

1 Images
Chemical Structure - Idazoxan hydrochloride, alpha2 Adrenoceptor antagonist and I2 ligand (AB141130)
  • Chemical Structure

Lab

Chemical Structure - Idazoxan hydrochloride, alpha2 Adrenoceptor antagonist and I2 ligand (AB141130)

2D chemical structure image of ab141130, Idazoxan hydrochloride, alpha2Adrenoceptor antagonist and I2 ligand

Key facts

CAS number

79944-56-2

Purity

>99%

Form

Solid

form

Molecular weight

240.68 Da

Molecular formula

C<sub>1</sub><sub>1</sub>H<sub>1</sub><sub>3</sub>ClN<sub>2</sub>O<sub>2</sub>

PubChem

154494

Nature

Synthetic

Solubility

Soluble in water to 100 mM

Biochemical name

Idazoxan hydrochloride

Biological description

α2 Adrenoceptor antagonist and I2 ligand. Improves motor symptoms and decreases dyskinesia in Parkinson's disease models. Also induces apoptosis. Active *in vivo*.

Canonical smiles

C1CN=C(N1)C2COC3=CC=CC=C3O2.Cl

InChi

InChI=1S/C11H12N2O2.ClH/c1-2-4-9-8(3-1)14-7-10(15-9)11-12-5-6-13-11;/h1-4,10H,5-7H2,(H,12,13);1H

InChiKey

MYUBYOVCLMEAOH-UHFFFAOYSA-N

IUPAC Name

2-(2,3-dihydro-1,4-benzodioxin-3-yl)-4,5-dihydro-1H-imidazole;hydrochloride

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
The product can be stored for up to 12 months
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The alpha-2 adrenergic receptors including receptor subtypes like ADRA2B ADRA2C and alpha-2A function as G protein-coupled receptors that inhibit the release of norepinephrine and other neurotransmitters in the central and peripheral nervous system. These receptors have a mass close to 50 kDa and express in various tissues including the brain spinal cord and vascular smooth muscles. Additionally Idazoxan acts as an antagonist ligand for these receptors. Another key protein TDP1 is known for its role in DNA repair processes while Geminin is involved in regulating DNA replication. Moreover Estrogen Related Receptor alpha (ERRα) is a nuclear receptor that influences metabolic processes.
Biological function summary

Alpha-adrenergic receptors including the ADRA2B and ADRA2C modulate neurochemical release and vascular tone contributing to responses such as vasoconstriction and lowering of blood pressure. Not functioning alone these receptors can be part of larger receptor complexes that coordinate multiple signal cascades. TDP1 plays a significant role in maintaining DNA integrity collaborating with other DNA repair proteins. Geminin on the other hand ensures proper DNA replication without over-replication. ERRα regulates energy homeostasis and lipid metabolism through its influence on gene transcription-related pathways.

Pathways

The alpha-2 adrenergic receptors participate significantly in adrenergic signaling impacting cellular responses to stress and metabolic function. They involve proteins such as G-proteins and other neurotransmitter-related proteins. Meanwhile TDP1 is essential in the DNA repair pathway associated with phosphodiester bonds and is linked to proteins engaged in coordinating DNA damage responses. ERRα operates within metabolic pathways particularly influencing pathways related to mitochondrial biogenesis and oxidative phosphorylation alongside key metabolic enzymes.

Dysregulation of alpha-2 adrenergic receptors links to hypertension and stress-related conditions as they impact cardiovascular and nervous system functions. Their altered function might also engage different adrenergic receptor subtypes impacting other physiological responses. TDP1 mutations can associate with neurodegenerative disorders like Huntington's disease implicating proteins involved in DNA repair cascades. Meanwhile ERRα has been connected with metabolic diseases such as diabetes linking it to disorders through altered metabolic protein interactions.
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Product protocols

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