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AB145223

IDE 2, endoderm formation inducer

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MW 240.3 Da, Purity >98%. Cell-permeable definitive endoderm formation inducer (EC50 = 223 nM, induction of Sox17 expression in ESCs) similar to IDE 1 (ab145222). Activates TGF-β signaling and downstream Smad2 phosphorylation. Upregulates Nodal expression. Induces gut tube formation in vivo. .
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Chemical Structure - IDE 2, endoderm formation inducer (AB145223)
  • Chemical Structure

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Chemical Structure - IDE 2, endoderm formation inducer (AB145223)

2D chemical structure image of ab145223, IDE 2, endoderm formation inducer

Key facts

CAS number

1136466-93-7

Purity

>98%

Molecular weight

240.3 Da

Molecular formula

C<sub>1</sub><sub>2</sub>H<sub>2</sub><sub>0</sub>N<sub>2</sub>O<sub>3</sub>

PubChem

23836158

Nature

Synthetic

Solubility

Soluble in water to 20 mM

Soluble in ethanol to 100 mM

Soluble in DMSO to 100 mM

Biochemical name

7-(2-Cyclopentylidenehydrazinyl)-7-oxoheptanoic acid

Biological description

Cell-permeable definitive endoderm formation inducer (EC50 = 223 nM, induction of Sox17 expression in ESCs) similar to IDE 1 (ab145222). Activates TGF-β signaling and downstream Smad2 phosphorylation. Upregulates Nodal expression. Induces gut tube formation in vivo.

Canonical smiles

C1CCC(=NNC(=O)CCCCCC(=O)O)C1

InChi

InChI=1S/C12H20N2O3/c15-11(8-2-1-3-9-12(16)17)14-13-10-6-4-5-7-10/h1-9H2,(H,14,15)(H,16,17)

InChiKey

CVYPYYPTFNVREL-UHFFFAOYSA-N

IUPAC Name

7-(2-cyclopentylidenehydrazinyl)-7-oxoheptanoic acid

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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