MW 454.3 Da. Selective, Ca2+ permeable GluR2-lacking AMPA receptor blocker (IC50 values are 2.6 and 1102 μM for GluR2-lacking and GluR2-containing receptors, respectively). Blocks NMDA receptor-mediated currents. Shows anticonvulsant effects in vivo.
Also available in simple stock solutions (ab146737) - add 1 ml of water to get an exact, ready-to-use concentration.
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- Frontiers in molecular neuroscience 14:6602082021Secreted Amyloid Precursor Protein-Alpha Enhances LTP Through the Synthesis and Trafficking of Ca-Permeable AMPA Receptors.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRhys W Livingstone,Megan K Elder,Anurag Singh,Courteney M Westlake,Warren P Tate,Wickliffe C Abraham,Joanna M WilliamsPubMed 33867938
- Cell reports 34:1087412021A circuit of mossy cells controls the efficacy of memory retrieval by Gria2I inhibition of Gria2.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXinyan Li,Wenting Chen,Quntao Yu,Qingping Zhang,Tongmei Zhang,Xian Huang,Hao Li,Aodi He,Hongyan Yu,Wei Jing,Huiyun Du,Xiao Ke,Bing Zhang,Qing Tian,Rong Liu,Youming LuPubMed 33596426
- Cell reports 25:168-182.e62018Activity-Dependent Netrin-1 Secretion Drives Synaptic Insertion of GluA1-Containing AMPA Receptors in the Hippocampus.Applications:Unspecified applicationReactive species:Unspecified reactive speciesStephen D Glasgow,Simon Labrecque,Ian V Beamish,Sarah Aufmkolk,Julien Gibon,Dong Han,Stephanie N Harris,Paul Dufresne,Paul W Wiseman,R Anne McKinney,Philippe Séguéla,Paul De Koninck,Edward S Ruthazer,Timothy E KennedyPubMed 30282026
Key facts
- CAS number
- 121034-89-7
- Form
- Solid
- Molecular weight
- 454.3 Da
- Molecular formula
- C19H38Br2N2
- PubChem identifier
- 6604954
- Nature
- Synthetic
Target data
Recommended products
MW 454.3 Da. Selective, Ca2+ permeable GluR2-lacking AMPA receptor blocker (IC50 values are 2.6 and 1102 μM for GluR2-lacking and GluR2-containing receptors, respectively). Blocks NMDA receptor-mediated currents. Shows anticonvulsant effects in vivo.
Also available in simple stock solutions (ab146737) - add 1 ml of water to get an exact, ready-to-use concentration.
Key facts
- CAS number
- 121034-89-7
- Form
- Solid
- Molecular weight
- 454.3 Da
- Molecular formula
- C19H38Br2N2
- PubChem identifier
- 6604954
- Nature
- Synthetic
- Solubility
Soluble in water to 100 mM.
Soluble in DMSO to 100 mM.
- Biochemical name
- 5-(1-Adamantylmethylamino)pentyl-trimethylazanium;bromide;hydrobromide
- Biological description
Selective, Ca2+ permeable GluR2-lacking AMPA receptor blocker (IC50 values are 2.6 and 1102 μM for GluR2-lacking and GluR2-containing receptors, respectively). Blocks NMDA receptor-mediated currents. Shows anticonvulsant effects in vivo.
Also available in simple stock solutions (ab146737) - add 1 ml of water to get an exact, ready-to-use concentration.- Canonical SMILES
- C[N+](C)(C)CCCCCNCC12CC3CC(C1)CC(C3)C2.Br.[Br-]
- InChI
- InChI=1S/C19H37N2.2BrH/c1-21(2,3)8-6-4-5-7-20-15-19-12-16-9-17(13-19)11-18(10-16)14-19;;/h16-18,20H,4-15H2,1-3H3;2*1H/q+1;;/p-1
- InChIKey
- CQTDZUSQSTUZDA-UHFFFAOYSA-M
- IUPAC name
- 5-(1-adamantylmethylamino)pentyl-trimethylazanium;bromide;hydrobromide
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- Ambient
- Appropriate long-term storage conditions
- Ambient
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
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1 product image
Chemical Structure - IEM-1460, GluR2 lacking AMPA receptor blocker (ab141507)
2D chemical structure image of ab141507, IEM-1460, GluR2 lacking AMPA receptor blocker
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