JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB141507

IEM-1460, GluR2 lacking AMPA receptor blocker

Be the first to review this product! Submit a review

|

(3 Publications)

MW 454.3 Da. Selective, Ca2+ permeable GluR2-lacking AMPA receptor blocker (IC50 values are 2.6 and 1102 μM for GluR2-lacking and GluR2-containing receptors, respectively). Blocks NMDA receptor-mediated currents. Shows anticonvulsant effects in vivo.

Also available in simple stock solutions (ab146737) - add 1 ml of water to get an exact, ready-to-use concentration.
1 Images
Chemical Structure - IEM-1460, GluR2 lacking AMPA receptor blocker (AB141507)
  • Chemical Structure

Lab

Chemical Structure - IEM-1460, GluR2 lacking AMPA receptor blocker (AB141507)

2D chemical structure image of ab141507, IEM-1460, GluR2 lacking AMPA receptor blocker

Key facts

CAS number

121034-89-7

Form

Solid

form

Molecular weight

454.3 Da

Molecular formula

C<sub>1</sub><sub>9</sub>H<sub>3</sub><sub>8</sub>Br<sub>2</sub>N<sub>2</sub>

PubChem

6604954

Nature

Synthetic

Solubility

Soluble in water to 100 mM

Soluble in DMSO to 100 mM

Biochemical name

5-(1-Adamantylmethylamino)pentyl-trimethylazanium;bromide;hydrobromide

Biological description

Selective, Ca2+ permeable GluR2-lacking AMPA receptor blocker (IC50 values are 2.6 and 1102 μM for GluR2-lacking and GluR2-containing receptors, respectively). Blocks NMDA receptor-mediated currents. Shows anticonvulsant effects in vivo.

Also available in simple stock solutions (ab146737) - add 1 ml of water to get an exact, ready-to-use concentration.

Canonical smiles

C[N+](C)(C)CCCCCNCC12CC3CC(C1)CC(C3)C2.Br.[Br-]

InChi

InChI=1S/C19H37N2.2BrH/c1-21(2,3)8-6-4-5-7-20-15-19-12-16-9-17(13-19)11-18(10-16)14-19;;/h16-18,20H,4-15H2,1-3H3;2*1H/q+1;;/p-1

InChiKey

CQTDZUSQSTUZDA-UHFFFAOYSA-M

IUPAC Name

5-(1-adamantylmethylamino)pentyl-trimethylazanium;bromide;hydrobromide

style
left-column

Complementary Products

Proteins & Peptides

AB128447

Recombinant Human UBE2M/UBC12 protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human UBE2M/UBC12 protein (His tag N-Terminus) (AB128447)

  • 0
  • 0
Proteins & Peptides

AB7403

Streptavidin (HRP)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Streptavidin (HRP) (AB7403)

  • 5
  • 7
Proteins & Peptides

AB280753

Recombinant Human PD1 protein

Mass Spectrometry - Recombinant Human PD1 protein (AB280753)

  • 0
  • 0
Proteins & Peptides

AB233664

Recombinant Rat Sonic Hedgehog protein

SDS-PAGE - Recombinant Rat Sonic Hedgehog protein (AB233664)

  • 0
  • 0
style
left-column
style
left-column

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
style
left-column
style
left-column
style
left-column

Product protocols

style
left-column

Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in molecular neuroscience 14:660208 PubMed33867938

2021

Secreted Amyloid Precursor Protein-Alpha Enhances LTP Through the Synthesis and Trafficking of Ca-Permeable AMPA Receptors.

Applications

Unspecified application

Species

Unspecified reactive species

Rhys W Livingstone,Megan K Elder,Anurag Singh,Courteney M Westlake,Warren P Tate,Wickliffe C Abraham,Joanna M Williams

Cell reports 34:108741 PubMed33596426

2021

A circuit of mossy cells controls the efficacy of memory retrieval by Gria2I inhibition of Gria2.

Applications

Unspecified application

Species

Unspecified reactive species

Xinyan Li,Wenting Chen,Quntao Yu,Qingping Zhang,Tongmei Zhang,Xian Huang,Hao Li,Aodi He,Hongyan Yu,Wei Jing,Huiyun Du,Xiao Ke,Bing Zhang,Qing Tian,Rong Liu,Youming Lu

Cell reports 25:168-182.e6 PubMed30282026

2018

Activity-Dependent Netrin-1 Secretion Drives Synaptic Insertion of GluA1-Containing AMPA Receptors in the Hippocampus.

Applications

Unspecified application

Species

Unspecified reactive species

Stephen D Glasgow,Simon Labrecque,Ian V Beamish,Sarah Aufmkolk,Julien Gibon,Dong Han,Stephanie N Harris,Paul Dufresne,Paul W Wiseman,R Anne McKinney,Philippe Séguéla,Paul De Koninck,Edward S Ruthazer,Timothy E Kennedy
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com