JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB287028

IITZ-01

Be the first to review this product! Submit a review

|

(0 Publication)

MW 482.5 Da, Purity >98%. IITZ-01 (ab287028) is a potent lysosomotropic autophagy inhibitor; displays >10-fold potent autophagy inhibition than Chloroquine; enhances autophagosome accumulation but inhibits autophagosomal degradation by impairing lysosomal function, finally resulting in the inhibition of autophagy. Displays potent anticancer activity.

Key facts

CAS number

1807988-47-1

Purity

>98%

Form

Solid

form

Molecular weight

482.5 Da

Molecular formula

C<sub>2</sub><sub>6</sub>H<sub>2</sub><sub>3</sub>FN<sub>8</sub>O

PubChem

134817273

Nature

Synthetic

Solubility

Soluble in DMSO to >100 mM

Biochemical name

CID 134817273

Biological description

IITZ-01 (ab287028) is a potent lysosomotropic autophagy inhibitor; displays >10-fold potent autophagy inhibition than Chloroquine; enhances autophagosome accumulation but inhibits autophagosomal degradation by impairing lysosomal function, finally resulting in the inhibition of autophagy. Displays potent anticancer activity.

Canonical smiles

C1COCCN1C2=NC(=NC(=N2)NC3=CC=C(C=C3)F)NC4=CC=C(C=C4)C5=NC6=CC=CC=C6N5

InChi

InChI=1S/C26H23FN8O/c27-18-7-11-20(12-8-18)29-25-32-24(33-26(34-25)35-13-15-36-16-14-35)28-19-9-5-17(6-10-19)23-30-21-3-1-2-4-22(21)31-23/h1-12H,13-16H2,(H,30,31)(H2,28,29,32,33,34)

InChiKey

XGEDDGLPNSLBFE-UHFFFAOYSA-N

IUPAC Name

4-N-[4-(1H-benzimidazol-2-yl)phenyl]-2-N-(4-fluorophenyl)-6-morpholin-4-yl-1,3,5-triazine-2,4-diamine

style
left-column

Product details

This product is manufactured by BioVision, an Abcam company and was previously called B2378 IITZ-01. B2378-5 is the same size as the 5 mg size of ab287028.
style
left-column

Properties and storage information

Shipped at conditions
Blue Ice
Appropriate long-term storage conditions
-20°C
style
left-column
style
left-column
style
left-column

Product protocols

style
left-column
style
left-column
style
right-column

Complementary Products

Biochemicals

AB141475

Vinblastine sulfate, Microtubule dynamics inhibitor

Chemical Structure - Vinblastine sulfate, Microtubule dynamics inhibitor (AB141475)

  • 0
  • 0
Biochemicals

AB287026

SRT-3025 hydrochloride

  • 0
  • 0
Biochemicals

AB287029

GIBH-130

  • 0
  • 0
Biochemicals

AB144526

Tranylcypromine, MAO inhibitor

Chemical Structure - Tranylcypromine, MAO inhibitor (AB144526)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com