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AB216471

IKK-16, IkappaB kinase inhibitor

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(3 Publications)

MW 520.1 Da. Potent, selective IκB kinase (IKK) inhibitor (IC50 values are 40, 70 and 200 nM for IKKβ, IKK complex and IKKα respectively). Inhibits TNF-α-stimulated IκB degradation and expression of adhesion molecules E-selectin, ICAM and VCAM. Inhibits LPS-induced TNF-α release in vivo and neutrophil extravasion in thioglycollate-induced peritonitis.
2 Images
Functional Studies - IKK-16, IkappaB kinase inhibitor (AB216471)
  • FuncS

PubMed

Functional Studies - IKK-16, IkappaB kinase inhibitor (AB216471)

Inhibition of the TAK1-NFkB axis phenocopies FLT3-L deprivation.

A) Percentage of Annexin V-positive CB MLL-AF9 cells after 24 hours incubation with DMSO or AZ-TAK1 inhibitor or IKK VII in different concentrations (technical triplicate ± s.d of 3 independent experiments).

Carretta et al PLoS One. 2017 Dec 14;12(12):e0189102. doi: 10.1371/journal.pone.0189102. eCollection 2017. Fig 5. Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/

Chemical Structure - IKK-16, IkappaB kinase inhibitor (AB216471)
  • Chemical Structure

Lab

Chemical Structure - IKK-16, IkappaB kinase inhibitor (AB216471)

2D chemical structure image of ab216471, IKK-16, IkappaB kinase inhibitor

Key facts

CAS number

1186195-62-9

Form

Solid

form

Molecular weight

520.1 Da

Molecular formula

C<sub>2</sub><sub>8</sub>H<sub>3</sub><sub>0</sub>ClN<sub>5</sub>OS

PubChem

56972179

Nature

Synthetic

Biochemical name

IKK 16 (hydrochloride)

Biological description

Potent, selective IκB kinase (IKK) inhibitor (IC50 values are 40, 70 and 200 nM for IKKβ, IKK complex and IKKα respectively). Inhibits TNF-α-stimulated IκB degradation and expression of adhesion molecules E-selectin, ICAM and VCAM. Inhibits LPS-induced TNF-α release in vivo and neutrophil extravasion in thioglycollate-induced peritonitis.

Canonical smiles

C1CCN(C1)C2CCN(CC2)C(=O)C3=CC=C(C=C3)NC4=NC=CC(=N4)C5=CC6=CC=CC=C6S5.Cl

InChi

InChI=1S/C28H29N5OS.ClH/c34-27(33-17-12-23(13-18-33)32-15-3-4-16-32)20-7-9-22(10-8-20)30-28-29-14-11-24(31-28)26-19-21-5-1-2-6-25(21)35-26;/h1-2,5-11,14,19,23H,3-4,12-13,15-18H2,(H,29,30,31);1H

InChiKey

XFVDIVQCZWDBCW-UHFFFAOYSA-N

IUPAC Name

[4-[[4-(1-benzothiophen-2-yl)pyrimidin-2-yl]amino]phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone;hydrochloride

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Product details

This product is manufactured by BioVision, an Abcam company and was previously called B1087 IKK16. B1087-25 is the same size as the 25 mg size of ab216471.
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions
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Product protocols

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Cell death and differentiation 29:1211-1227 PubMed34862482

2021

The caspase-6-p62 axis modulates p62 droplets based autophagy in a dominant-negative manner.

Applications

Unspecified application

Species

Unspecified reactive species

Evelina Valionyte,Yi Yang,Sophie A Griffiths,Amelia T Bone,Elizabeth R Barrow,Vikram Sharma,Boxun Lu,Shouqing Luo

Glia 69:1478-1493 PubMed33556209

2021

Expression and secretion of apoE isoforms in astrocytes and microglia during inflammation.

Applications

Unspecified application

Species

Unspecified reactive species

Maria Fe Lanfranco,Jordy Sepulveda,Gregory Kopetsky,G William Rebeck

PloS one 12:e0189102 PubMed29240787

2017

BRD3/4 inhibition and FLT3-ligand deprivation target pathways that are essential for the survival of human MLL-AF9+ leukemic cells.

Applications

Unspecified application

Species

Unspecified reactive species

Marco Carretta,Annet Z Brouwers-Vos,Matthieu Bosman,Sarah J Horton,Joost H A Martens,Edo Vellenga,Jan Jacob Schuringa
View all publications
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