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MW 520.1 Da. Potent, selective IκB kinase (IKK) inhibitor (IC50 values are 40, 70 and 200 nM for IKKβ, IKK complex and IKKα respectively). Inhibits TNF-α-stimulated IκB degradation and expression of adhesion molecules E-selectin, ICAM and VCAM. Inhibits LPS-induced TNF-α release in vivo and neutrophil extravasion in thioglycollate-induced peritonitis.

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Images

Chemical Structure - IKK-16, IkappaB kinase inhibitor (AB216471), expandable thumbnail
  • Functional Studies - IKK-16, IkappaB kinase inhibitor (AB216471), expandable thumbnail

Publications

Key facts

CAS number
1186195-62-9
Form
Solid
Molecular weight
520.1 Da
Molecular formula
C28H30ClN5OS
PubChem identifier
56972179
Nature
Synthetic

Target data

Recommended products

MW 520.1 Da. Potent, selective IκB kinase (IKK) inhibitor (IC50 values are 40, 70 and 200 nM for IKKβ, IKK complex and IKKα respectively). Inhibits TNF-α-stimulated IκB degradation and expression of adhesion molecules E-selectin, ICAM and VCAM. Inhibits LPS-induced TNF-α release in vivo and neutrophil extravasion in thioglycollate-induced peritonitis.

Key facts

PubChem identifier
56972179
Biochemical name
IKK 16 (hydrochloride)
Biological description

Potent, selective IκB kinase (IKK) inhibitor (IC50 values are 40, 70 and 200 nM for IKKβ, IKK complex and IKKα respectively). Inhibits TNF-α-stimulated IκB degradation and expression of adhesion molecules E-selectin, ICAM and VCAM. Inhibits LPS-induced TNF-α release in vivo and neutrophil extravasion in thioglycollate-induced peritonitis.

Canonical SMILES
C1CCN(C1)C2CCN(CC2)C(=O)C3=CC=C(C=C3)NC4=NC=CC(=N4)C5=CC6=CC=CC=C6S5.Cl
InChI
InChI=1S/C28H29N5OS.ClH/c34-27(33-17-12-23(13-18-33)32-15-3-4-16-32)20-7-9-22(10-8-20)30-28-29-14-11-24(31-28)26-19-21-5-1-2-6-25(21)35-26;/h1-2,5-11,14,19,23H,3-4,12-13,15-18H2,(H,29,30,31);1H
InChIKey
XFVDIVQCZWDBCW-UHFFFAOYSA-N
IUPAC name
[4-[[4-(1-benzothiophen-2-yl)pyrimidin-2-yl]amino]phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone;hydrochloride

Storage

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions

Notes

This product is manufactured by BioVision, an Abcam company and was previously called B1087 IKK16. B1087-25 is the same size as the 25 mg size of ab216471.

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2 product images

  • Chemical Structure - IKK-16, IkappaB kinase inhibitor (ab216471), expandable thumbnail

    Chemical Structure - IKK-16, IkappaB kinase inhibitor (ab216471)

    2D chemical structure image of ab216471, IKK-16, IkappaB kinase inhibitor

  • Functional Studies - IKK-16, IkappaB kinase inhibitor (ab216471), expandable thumbnail
    Carretta et al PLoS One. 2017 Dec 14;12(12):e0189102. doi: 10.1371/journal.pone.0189102. eCollection 2017. Fig 5. Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/

    Functional Studies - IKK-16, IkappaB kinase inhibitor (ab216471)

    Inhibition of the TAK1-NFkB axis phenocopies FLT3-L deprivation.

    A) Percentage of Annexin V-positive CB MLL-AF9 cells after 24 hours incubation with DMSO or AZ-TAK1 inhibitor or IKK VII in different concentrations (technical triplicate ± s.d of 3 independent experiments).

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Product protocols

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