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AB142109

IKK-epsilon Kinase Inhibitor II, Inhibitor of IkappaB kinases (IKK)

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MW 469.5 Da, Purity >97%. Key regulator of NF-κB signaling. Inhibitor of IκB kinases (IKK). One of three IKK isoforms-α, β, and ε-which have been linked to oncogenesis.

View Alternative Names

Cell cycle regulated protein kinase, Cellular Yes 1 protein, EC 2.7.11.1, FLJ11330, FTDALS4, HsT441, I-kappa-B kinase epsilon, IKK related kinase epsilon, IKK-epsilon, IKK-i, IKKE_HUMAN, IkBKE, Inducible I kappa-B kinase, Inhibitor of kappa light polypeptide gene enhancer in B cells kinase epsilon, Inhibitor of kappa light polypeptide gene enhancer in B cells, kinase of, epsilon, Inhibitor of nuclear factor kappa-B kinase subunit epsilon, KIAA0151, MGC125294, MGC125295, MGC125297, NAK, NF kB activating kinase, NF-kappa-B-activating kinase, PLK, PLK1_HUMAN, Polo-like kinase 1, Proto oncogene tyrosine protein kinase YES, Proto-oncogene c-Yes, STPK 13, Serine/threonine-protein kinase 13, Serine/threonine-protein kinase PLK1, Serine/threonine-protein kinase TBK1, T2K, TANK-binding kinase 1, TBK1_HUMAN, Tyrosine-protein kinase Yes, Viral oncogene yes 1 homolog 1, YES proto oncogene 1, Src family tyrosine kinase, YES1 proto oncogene, Src family tyrosine kinase, YES_HUMAN, Yamaguchi sarcoma oncogene, Yes 1, c Yes, p61-Yes, v yes 1 Yamaguchi sarcoma viral oncogene homolog 1

1 Images
Chemical Structure - IKK-epsilon Kinase Inhibitor II, Inhibitor of IkappaB kinases (IKK) (AB142109)
  • Chemical Structure

Lab

Chemical Structure - IKK-epsilon Kinase Inhibitor II, Inhibitor of IkappaB kinases (IKK) (AB142109)

2D chemical structure image of ab142109, IKK-epsilon Kinase Inhibitor II, Inhibitor of IkappaB kinases (IKK)

Key facts

CAS number

862812-98-4

Purity

>97%

Form

Solid

form

Molecular weight

469.5 Da

Molecular formula

C<sub>2</sub><sub>2</sub>H<sub>1</sub><sub>9</sub>N<sub>3</sub>O<sub>5</sub>S<sub>2</sub>

PubChem

11626927

Nature

Synthetic

Solubility

Soluble in DMSO

Biochemical name

IKK-3 Inhibitor

Biological description

Key regulator of NF-κB signaling. Inhibitor of IκB kinases (IKK). One of three IKK isoforms-α, β, and ε-which have been linked to oncogenesis.

Canonical smiles

COC1=C(C=C2C(=C1)N=CN2C3=CC(=C(S3)C#N)OCC4=CC=CC=C4S(=O)(=O)C)OC

InChi

InChI=1S/C22H19N3O5S2/c1-28-17-8-15-16(9-18(17)29-2)25(13-24-15)22-10-19(20(11-23)31-22)30-12-14-6-4-5-7-21(14)32(3,26)27/h4-10,13H,12H2,1-3H3

InChiKey

LDTAHRLHGHFHKP-UHFFFAOYSA-N

IUPAC Name

5-(5,6-dimethoxybenzimidazol-1-yl)-3-[(2-methylsulfonylphenyl)methoxy]thiophene-2-carbonitrile

Product details

This product is manufactured by BioVision, an Abcam company and was previously called 1811 IKK-e Kinase Inhibitor II. 1811-5 is the same size as the 5 mg size of ab142109.

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months

Product protocols

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