Iloprost, Prostaglandin (PGI2) analog

Key facts

CAS number

78919-13-8

Purity

>97%

Form

Liquid

form

Molecular weight

360.49 g/mol

Nature

Synthetic

Biological description

Prostaglandin (PGI₂) analog. Binds with high affinity to the human recombinant IP, EP₁ and EP₃ receptors (K_i values are 11 (IP and EP₁) and 56 nM (EP₃)). Higher selectivity over other prostanoid receptors.

Isomeric smiles

O[C@@H]1C[C@H](C/2)[C@H](CC2=CCCCC(O)=O)[C@H]1/C=C/[C@@H](O)C(C)CC#CC

IUPAC Name

(5E)-5-[(3aS,4R,5R,6aS)-Hexahydro-5-hydroxy-4-[(1E,3S)-3-hydroxy-4-methyl-1-octen-6-yn-1-yl]-2(1H)-pentalenylidene]pentanoic acid